UPDATE: SECuRE trial strikes again 67Cu-SAR-bisPSMA

[Maxone73]

Remember, the results were mostly obtained after ONE SINGLE dose and in taxane naive patients (but not completely taxane naive, taxane naive in castration resistant stage). I would say...not bad!

The SECuRE trial, evaluating 67Cu-SAR-bisPSMA for metastatic castration-resistant prostate cancer (mCRPC), shows promising results, especially in pre-chemotherapy patients.

A 92% response rate was observed in this group after a single dose, with significant PSA level reductions. Some patients experienced substantial PSA declines, even after prior actinium-225 treatment. The trial is progressing to Phase II with an expanded cohort focusing on pre-chemotherapy participants, also exploring combination therapy with enzalutamide.

The treatment demonstrates a favorable safety profile with mostly mild adverse events. These results suggest earlier intervention with 67Cu-SAR-bisPSMA could improve outcomes, potentially leading to a Phase III trial.

It could become a game changer! Hopefully soon!

prostatewarriors.com/2025/0...

[PCaWarrior]

Looks promising. Fingers crossed.

Secure pca trial flow

[PC-22]

Hello. Maxone73,

I guess I would be considered taxane naive since I have not had Chemotherapy just yet. And this new trial has just opened up this month right here in my own backyard so to speak. I think it’s worth a shot as all my Mets seem to be in the bones only.

I did recently get 5 Proton external radiation ☢️ to my acetabulum and am being scheduled to have additional radiation to the other spots via photon RT. So hopefully that doesn’t disqualify me.

[PC-22 in reply to PC-22]

Oops, sorry I thought I was responding to a different thread. So please disregard my last reply as it probably doesn’t appear to make sense.

But I am in New Mexico so not exactly a lot of options.

[Maxone73 in reply to PC-22]

healthunlocked.com/fight-pr...

check this out as well, not as close to NM but you never know!