The WOMBAT Trial (Working Out M0 Bipolar Androgen Therapy) investigates the efficacy of bipolar androgen therapy (BAT) in extending metastasis-free survival for patients with M0 castration-resistant prostate cancer (CRPC) experiencing rising PSA levels on darolutamide, without visible metastases.
This Phase 2, open-label trial targets 69 participants in New South Wales, Australia, with recruitment spanning November 2024 to August 2027.
Participants will receive testosterone enanthate (500mg, intramuscularly) in 56-day cycles, alongside darolutamide and standard castration therapy. The study also examines safety, PSA progression, quality of life, and hormone kinetics. Sponsored by Bayer and led by the ANZUP Cancer Trials Group, this innovative trial aims to redefine CRPC treatment pathways by reintroducing testosterone in controlled bursts.
The above website is for aPatent by dr Bieber for “dogosterone” very important for dogs who have been brutally operated on by spaying and neutering instead of doing it by sparring the hormone producing organs in our lovely pets.
That patent is a great read and my baby is doing so much better.
Testosterone Enanthate: Chemical Formula C28H40Os
0029 Testosterone enanthate is one of the main forms of testosterone prescribed to men in the United States. It is a slow-acting ester with a release time between 8-10 days. It is available in the United States under the trademark DELAT ESTRYL which is suspended in sesame oil. Testosterone enanthate is typically injected anywhere between once every week to once every three weeks. Generic testosterone enan thate can also be obtained through a compounding pharmacy; Such pharmacies can mix T-enanthate in Sesame oil, cotton seed oil, or any other appropriate oil.
0030 Testosterone Cypionate: Chemical Formula C27HoOs
0031 Testosterone cypionate is the other principal inject able form of testosterone prescribed to men in the United States. It is a slow-acting ester with a release time between 8-10 days, similar to that of testosterone enanthate. It is avail able in the United States under the brand DEPO-TEST OSTERONE, in which the testosterone cypionate is sus pended in cottonseed oil. Testosterone cypionate is typically injected in humans anywhere between once every week to once every three weeks. For dogs, the period between injec tions is typically every 3 to 6 weeks. Generic testosterone cypionate can also be obtained through a compounding phar macy; such pharmacies can mix testosterone-cypionate in sesame oil, cotton seed, or any other appropriate oil.
Very promising trial and I especially love the name -- WOMBAT !!! Most urologists hate the idea of BAT or T replacement therapy. Maybe a change may be coming.
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Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review