metastatic directed therapy (esp with SRBT), the approach is shifting

[Maxone73]

I am a bit disappointed, most of the doctors interviewed for the original article are Italian, yet in Italy this approach is not widespread….bah

Metastasis-directed therapy (MDT), particularly stereotactic body radiotherapy (SBRT), is transforming metastatic prostate cancer treatment by offering tailored strategies that move beyond traditional lifelong androgen deprivation therapy (ADT). Studies like STOMP and ORIOLE have shown that MDT can significantly delay the initiation of ADT and improve progression-free survival. Combining MDT with short-term ADT, as explored in the EXTEND trial, has further enhanced outcomes, allowing patients to maintain normal testosterone levels longer. In cases of oligoprogressive castration-resistant prostate cancer, the ARTO trial demonstrated that MDT could delay the need for additional systemic therapies. Additionally, the PROLONG study found that MDT, when used alongside systemic therapies for de novo low-volume hormone-sensitive prostate cancer, improved survival. Even in polymetastatic disease, MDT has proven to be a safe and feasible option. These findings indicate that MDT is not only effective but also adaptable, offering patients more personalized treatment approaches while improving their quality of life.

prostatewarriors.com/2025/0...

[dhccpa]

Wouldn't it hurt the drug makers? I mean, is that possible?

[Maxone73 in reply to dhccpa]

Competition is always good, plus there are sbrt machines makers as well 😀

[dhccpa in reply to Maxone73]

I wonder if the two groups ever have a real shootout.

Seriously, I like the idea of spot radiation. I think others Pooh Pooh it.

[Maxone73 in reply to dhccpa]

I like the idea too, I should contact one of the Dr that wrote the original report in Milan. Where I go, even if a center of excellence they would consider srbt only palliative if I had symptoms. But now my pet scan says that even if still active, my mets are not as many as before. I would give it a try to enhance triplet therapy

[GreenStreet]

Its pretty much what I have been doing. I am oligometastic and had Cyberknife treatement to a lymph node plus 6 months bicalutamide to knock it back. That was over 3 years ago. £ monthly PSA monitoring. Expect further treatment soon based on PSA progression but most recent Pet Scan has not located anything

[cigafred]

I had it based on the attached MRI summary. N=1, but seems to have been good for me.

MRI