Phase 1 ACCEL trial recruiting: AC-225-PSMA-62 for OLIGOMETASTATIC HSPC and mCRPC

[Maxone73]

I am not oligometastatic, dammit! But this could really be something worth trying! It is, at least from preclinical studies, a more targeted version of the previous Actinium based therapies.

The ACCEL trial is a Phase 1 clinical study testing Actinium-225-labeled PSMA-62, a targeted radioligand therapy for oligometastatic hormone-sensitive prostate cancer and metastatic castration resistant prostate cancer.

This therapy combines Actinium-225, a powerful alpha-emitting radioisotope, with PSMA-62, a molecule that binds to Prostate-Specific Membrane Antigen (PSMA) on cancer cells.

By delivering precise radiation, it aims to destroy cancer cells while sparing healthy tissue. Early results show strong anti-tumor effects with manageable side effects.

prostatewarriors.com/2025/0...

[Fonske]

Recruiting only in Canada.

When in Europe?

[Maxone73 in reply to Fonske]

I wish I knew the answer! But you never know!

[Fonske in reply to Maxone73]

Please, do not get me wrong because I love beaucoup nos amis canadiens 😍

I even have relatives in Quebec 😍

[Maxone73 in reply to Fonske]

Don't worry, soon Canada will become the 21st region of Italy, so it will all be closer to Belgium

[Petertanner]

Current trial with Actinium 225-PSMA-TRILLIUM ongoing at Royal Marsden in the UK.

[GreenStreet in reply to Petertanner]

thanks for the info 👍

[Islandboy2021]

Thanks for posting this trial. I am talking to the trial doctors in Vancouver about this trial. I have missed a few trials in the last year and a half. Its not easy to get into these as they fill up quickly. I did notice they are going to have the same trial in Hamilton Ontario. If I don't get into the Vancouver trial I will try Hamilton. My Father lives nearby there and I only would have to cover my flights.

I did have one concern with the eligibility criteria . I have had chemo therapy a number of times. I handled the treatments fine when using Grastofil. It mentions only having chemo once.

I am at the point of no return. If I don't get treatment soon I will be in hospice care within a few weeks. The tumors are starting to effect my bone marrow and I am having pain everywhere.

[Maxone73 in reply to Islandboy2021]

Some trials can extend their reach by something called compassionate use, your MO surely knows about it. I do not see anything that would disqualify you for the trial anyway. Is Canada your only option?

[Islandboy2021]

The compassionate use is a great option. I will make sure that we ask for that. Canada is the best option for me. I am not wealthy and have a family with one daughter still at home. I have been working since diagnosis in 2017. I feel now that I will have to step away from work soon. I have been lucky with work as I have been able to work from home some and make my own schedules.

Thanks for all your posts, it really helps to figure out the next steps.

[Maxone73 in reply to Islandboy2021]

Have your MO check also the following:

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

clinicaltrials.gov/study/NC...

You will have to consider various factors as every treatment has its limitations