Great update: 67Cu-SAR-bisPSMA gets fast tracked by FDA

[Maxone73]

And it looks like it is way more reliable than 177Lu...

The FDA has granted Fast Track Designation to 67Cu-SAR-bisPSMA, a novel radiopharmaceutical therapy for metastatic castration-resistant prostate cancer (mCRPC). Preliminary data from the SECuRE trial show promising results, with 73% of patients experiencing PSA reductions and 45% seeing drops greater than 50%. Notably, a patient who received two doses of 8 GBq 67Cu-SAR-bisPSMA achieved complete remission, with undetectable PSA levels for 13 months.

Final trial results are expected in September 2026, and continued remission in early responders could signal a breakthrough for advanced prostate cancer treatment.

prostatewarriors.com/2025/0...

[GardenReno]

sounds very promising

[DrawingSnowmen]

That's very exciting. If you were going to do a trial would you do Cu-67 or Ac-225?

[Maxone73 in reply to DrawingSnowmen]

I would try this first, then Ac because it seems to work well with micro mets 😀

[DrawingSnowmen in reply to Maxone73]

I don't think they'd let you do both currently. What they're reporting out so far seems similar in terms of percentages of any response and PSA50. Cu-67 seems like maybe fewer side effects?

[Graham49]

Thanks Maxone. I hope it is cheap enough for us to get it in the UK!

[Maxone73 in reply to Graham49]

Me too! I am worried about access now, I think we already have some great tools in the world.

[Islandboy2021 in reply to Maxone73]

Yes, access is the problem. I agree we have some great tools in the world but many countries don't offer them as SOC. So unless you are able to travel and pay for these tools out of pocket then you don't get the treatments that could extend your life.

[dhccpa]

PSA drops are always nice, but how about the Mets? Did they die or disappear?

[Maxone73 in reply to dhccpa]

Who knows? I know that today my psa went from 0.01 to 0.02 and I was almost freaking out!!! But then the nurse interviewed me and she said that not drinking anything for 10 hours before having my blood drawn is not a brilliant idea if i want reliable results! (I was in a hurry so like 5 minutes after waking up I was already in the car!)

[dhccpa in reply to Maxone73]

A waterless fast? Extreme discipline!

[Maxone73 in reply to dhccpa]

Nah, just a stupid thing to do, but between the cold weather and the early hour, I really didn't even think about drinking some water

[Maxone73 in reply to dhccpa]

Seriously, I will check, but when they talk about complete remission it usually means that it's not visible on the scans. If I remember correctly they have published also the guy's scan to show the response.

[dhccpa in reply to Maxone73]

Ok thanks!

[Maxone73 in reply to dhccpa]

claritypharmaceuticals.com/... there you go, but update to last october it was 13 months "cancer free", I don't know after that date

[dhccpa in reply to Maxone73]

Thanks I'll take a look

[Prostata]

Thank you Maxone73 for bringing us hope and briefing on news and updates. Wish you all the best!

[Maxone73 in reply to Prostata]

Daje!!!!