Herpes (or acyclovir usage) affecting... - Fertility Network UK

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Herpes (or acyclovir usage) affecting implantation after ivf embryo transfer?

Norregirl profile image
15 Replies

I have had herpes for about 10 years. I have noticed more outbreaks during stims. I've already had 2 failed transfers and am worried both that having herpes and /or taking acyclovir will affect implantation for my last transfer. I've read some conflicting studies on acyclovir and it's effect on implantation. Some say it increases implantation rates, some say it reduces. I'm already doing downregulation with zorodex for a few months, then considering prednisone and baby aspirin for the Fet as an immune protocol but worried about another outbreak complicating things.

Would love some advice.

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Norregirl profile image
Norregirl
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15 Replies
Seren0119 profile image
Seren0119

Low dose acyclovir (200mg) a day will help reduce chance of an outbreak and also prevent NK cells from increasing, hope that helps x

Norregirl profile image
Norregirl in reply to Seren0119

Yes! This was the info I was hoping for. Thank you!

When do you take it until?

Seren0119 profile image
Seren0119 in reply to Norregirl

Until the 12 week scan (when miscarriage rates are much lower) xx

DianeArnold profile image
DianeArnoldPartnerNurseFertility Network UK

Hi Norregirl. This is unfortunate, but I feel it would be goo to treat the herpes more befor the FET. Before transferring your last embryo. You will b b est guided by your specialist I’m sure. Good luck? Diane

Norregirl profile image
Norregirl in reply to DianeArnold

I'm downregulating for a couple of months so I could ask them. So you're saying its better to do before rather than taking it as part of my transfer cycle protocol?

DianeArnold profile image
DianeArnoldPartnerNurseFertility Network UK in reply to Norregirl

Hi. Hopefully the longer down regulation will help. Your specialist will be giving you the best chance. Diane

Norregirl profile image
Norregirl in reply to DianeArnold

It's a good thing to ask them now while I'm downregulating with zorodex. Glad for your suggestion!

lulubelly1983 profile image
lulubelly1983

I’ve had herpes for over 20years now and have a very mild outbreak around twice a year, I wondered has your clinic said if an outbreak in early pregnancy could cause a miscarriage? I haven’t been able to find any info on it at all, are you taking the medication to avoid an outbreak during transfer? TIA

Norregirl profile image
Norregirl in reply to lulubelly1983

Hi lulubelly I'm downregulating for a few months before my transfer so I'll ask my clinic whether an outbreak can cause a miscarriage. I know I asked my doctor this and she said no it doesn't affect the fetus but I'll check with my fertility clinic Dr as we as when I should start taking the antiviral. Will get back to you...

lulubelly1983 profile image
lulubelly1983 in reply to Norregirl

thank you it’s just I had a missed miscarriage (empty sac) at my 7wk scan and had very mild outbreak at around 4wks and I can’t help wonder if that’s why it happened or was that little egg always destined to not develop, fingers crossed for you make sure any prenatal vitamins you take don’t have L-arginine in, pregnacare plus does and with two days of started it I had an outbreak, I’ve been taking making my own beetroot, melon and ginger smoothies and have a glass a day this way you can get the same benefits that l-arginine provide without taking it 👍🏻

Norregirl profile image
Norregirl in reply to lulubelly1983

Oh my gosh I'm so sorry. I know it's easy to wonder. I've had 2 failed transfers and also had a hard time with myself around things I didn't do or did do it's so hard mentally. Sending you 💓

Norregirl profile image
Norregirl in reply to lulubelly1983

Hi lulubelly, I heard back from my fertility clinic on this and they didn't have an answer on this except that if I'm prone to outbreaks from the hormones, I should start taking acyclovir 2 weeks prior to my last transfer and for 2 weeks afterwards. Sorry I couldn't give you a more definite answer but I'm hoping you have another chance to add this to your protocol. 💜

lulubelly1983 profile image
lulubelly1983 in reply to Norregirl

Thank you good luck for you over the coming months, I’ve got my BFP and won’t be doing anymore cycles to just fingers crossed for my viability scan in a few weeks I’ve had again a very very mild outbreak around implantation and so nervous for my scan I’ve just never even thought to take anything for the herpes so was intrigued when they suggested to you to take a preventative to why they wanted you to thank you for getting back to me x

Norregirl profile image
Norregirl

Wow, amazing! Fingers crossed for your scan. Super good news 🙌

lulubelly1983 profile image
lulubelly1983

yes I’m chuffed I’m just trying to allow myself to get excited everywhere I’ve researched it says an recurrent outbreak does not effect pregnancy, and a blighted ovum egg can look normal but can have faulty chromosomes so will have its fate decided so I guess I have to just take this info and out it to bed 👍🏻

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