1 x failed fresh, 1 x failed FET. 1 x left - what to do?

[Clowden]

Hi all

Myself and husband just had our 2nd transfer (1st FET) which has failed 💔💔 we are gutted as we went in postive as such (lining was good, on progesterone injections aswell as cyclogest pessaries).

I am 32 with PCOS but fit and well - only symptom with PCOS is lack of cycles.

We had 1 x successful pregnancy using letrozole july 2022 but ended at sept 2022 at 8 weeks with MMC 💔

We only have 1 x embryo left as also lost one in thawing process. I feel extremely ovewhelmed and anxious as to what to think of next.

Has anyone any advice or similar stories? Would you do an ERA at this point? Im worried that either post MMC that internally there is damage or that something is happening with implantation.

Please advise or provide hope🤞❤️

Thanks

[Kitkat10]

hi, I’m sorry you are going through this but you still have very good chances of success. I had a mmc and they are very common, which I know doesn’t help, but they also show that implantation happened but the embryo stopped probably for genetic reasons (which is normal for a proportion of embryos no matter what age). Lots and lots of women have a successful pregnancy straight after a mmc and the clinic will likely do a scan to check the uterus is back to normal after the mmc. If you want to, you could ask for further testing. I had success on my third transfer and that seems to be fairly common. I see lots of stories where success happens after 2-4 transfers so try and hang in there, and try and be positive and prepare as well as you can for the next transfer. It’s a very tough process, keep going and best of luck 🍀🍀

[Hidden]

Morning Clowden, I’m in a similar situation. 1 x failed fresh and 1 x FET transfer. Absolutely gutting as I am using donor eggs. I had a consultation this week and they are investigating recurring implantation failure before I transfer my last and only embie. My consultant has requested immunology bloods and a hysteroscopy before we make any further decisions. My treatment is NHS and the consultant feels the bloods may reveal something but if not I will be having the ERA. Have you discussed your concerns with your consultant?

[Dreamydoran]

I had an Era test and that gave be the best time for me for transfer.. after doing more research myself and with my Dr I requested a maytrice lab test for checking immunity within the uterus.. (we all need some) we decided to take a low dose of prednisone which lowers the immunity.. weather that was the game changer.. who knows!! But after 18 rounds it was a case of I’d give anything a go.. it worked !!

I now have a 4 year old and we’ve just started our final cycle using the same protocol..

good luck

[BBHH1]

I would be encouraged to try natural with letrozol and monitoring in a clinic and considering trigger shot since you had success before and you are very young. Specially if you had that pregnancy within few months of letrozol. Sometimes nature is better than IVF! Good luck

[Newbies1 in reply to BBHH1]

Hi so sorry you are going through this. I was in a similar situation last year after a failed fresh cycle then a chemical after the FET. My clinic were not keen on any extra testing at that stage as they said it was just a numbers game however I wanted to rule out potential issues before transferring another embroyo. I decided to do the EMMA/ALICE/ERA trio test and believe this was the best decision I made in the whole IVF process. It shown my impantation window was out by 24 hours and also that I had low levels of good bacteria. I took a course of antibiotics followed by probiotics to address the low good bacteria and added an extra day or progesterone to my next cycle. Thankfully this worked and our miracle baby was born on Wednesday. I know some people are sceptical of the ERA test especially if you have had a miscarriage as they say implantation has happened but our consultant said to us a displaced window of 24 hours is significant and even if implantation occurred very unlikely to progress to healthy pregnancy so I really do believe without that test we wouldn’t have had the success we did. Please feel free to ask any questions and I wish you all the success in the world for your next transfer xxx