Our most recent cycle of a double embryo FET has failed and now we’re back to square one with no frosties left in the bank. So gutted and heartbroken. Seeing my husband break down and cry today has been one of the toughest days I’ve experienced on this journey. We had two untested 5AA OE/OS embryos transferred and not even a hint of a line on the FRER this morning.
Our history is stage 4 endo (excised in 2018 which thankfully has not come back) and diffuse Adenomyosis. Husband has not had dna frag test but his normal sperm tests have come back with flying colours; so the clinic don’t believe there is any MFI in our case. So far we’ve had a total of 6 embryos transferred across 4 FETs with just a chemical pregnancy. We did fall pregnant naturally in 2020 but it resulted in a MMC.
Our wtf appointment is at the end of the month and I have no idea what Qs I should be asking or tests I should be requesting. I’ve had 3 laparoscopies (incl endo excision), 2 hysteroscopies (no issues), karyotype tests & thrombophilia screening (both normal). Any advice would be so welcome. xx
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KDA0510
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So sorry to hear about your BFN. Sending lots of love, ivf is so hard. I’d suggest getting your immunes tested (nk cells). Some ladies on this forum have seen success after having them treated.
Awww honey, I'm so so sorry! It's really hard, I completely understand. The only things I have to suggest is an ERA test but that's not cheap on top of a new cycle. You could also try steriod cover incase of NK cells. What a shitty day for you both! Huge hugs.xxx
Sorry I don’t have any advice but just wanted to say I’m sorry, BFN’s (especially one after another) are just brutality disappointing. Sending big hugs 💞xx
So sorry to hear this. I don't know your age but I suggest you ask the doctor if it is worth considering PGS. Also, given it's the 4th transfer and it still didn't work. If I were you, I would request to speak to the most experienced doctor in your clinic (e.g. at least 15 or 20 years' experience). You could also try to speak to top doctors from other clinics to get a second opinion before you start your next cycle. xx
So sorry to read this. It’s such a long, difficult journey.
It sounds like you definitely need a new approach - the embryos seem to be good quality, so perhaps it is a lining/implantation issue and you need steroids for inflammation. That’s what seemed to have worked for me.
Your embryos are fantastic quality by the sounds and given the circumstances of having 6 transfers I would push for more investigations and information on maybe why your womb is not excepting your lovely embryos.
Keep positive. At least you have an idea on what could be the problem to rectify this xxxx sending you hugs. As a stage 4 endo sufferer I know how difficult it can be.
So sorry to hear. It is so difficult- all of it. I would ask about autoimmune issues, thyroid issues, NK cells. The remedies include an autoimmune protocol - which includes steroids as someone else mentioned, or if it is your thyroid, they can put you on thyroid meds or intralipid infusions are used for anti phospholipid issues.
I am so sorry to hear this I have severe endometriosis and have had excision surgery in the past and a hysteroscopy and I also have adenomyosis, amongst other things, so I completely understand what you are going through. It is such a hard journey!
Have you had EMMA/ALICE/ERA tests? I would highly recommend them. Have you done any tests for autoimmune problems? We also did PGT A testing on our embryos.
One thing my consultant told me is that adenomyosis can affect implantation and cause. implantation failure and miscarriages. I suffered from both, but the good news is that, although it can be a harder journey, there is hope! My consultant told me that, before trying to get pregnant again, I needed to work on what wouldbe the 'baby's house' for 9 months, to make sure it was cozy... So, he advised me to try and improve my adenomyosis first. I was devastated as I just wanted to get on with things and move on and do another transfer, but he advised me against it and I am so glad I followed his advice. I was on hormonal treatment, Decapeptyl injections and then on Zoladex for 9 months or so and then I had an MRI that showed my adenomyosis had improved and here I am 18 week pregnant. I hope this gives you some hope. Please PM me if you have any questions or need any help with anything!
Sorry to hear this. This happened to me too - 4 transfers with 4 untested embryos. 1 miscarriage and 3 that just didn't implant. I requested recurrent pregnancy lost testing which my dr agreed to (we are in Canada so may not work like that in the UK). It didn't really find anything wrong with us, my doctor says most likely genetic issues with the embryos. My doctor said that normally what he'd do for patients like me is just another retrieval, and do genetic testing on the embryos. I've had chemo so can't do that and we're moving on to donor eggs. It's hard to imagine this ever working though after so many failures!
I realise it’s been a while since you posted but I wanted to say I’m so sorry to hear the transfers didn’t work. I hope you had the strength and courage to move through to your next steps.
I’m in a similar position and wondered what your next steps forwards were?
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I have severe endometriosis and have had excision surgery in the past and a hysteroscopy and I also have adenomyosis, amongst other things, so I completely understand what you are going through. It is such a hard journey!
4th transfer BFN - immune tests? 
Day 3 quality and where to go from here...
Where to go from here 
4th failed cycle - where to go now?
Day 5 transfer complete! Here we go for the long wait!!!
