Chemical: Hiya, We have our recheck of... - Fertility Network UK

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Chemical

Boo718 profile image
11 Replies

Hiya,

We have our recheck of hcg tomorrow but the doctors think it is a chemical because the number is so low.

It was a PGS tested chromosomally normal embryo. Can anyone help with questions to ask? Other than just why?

Should we check other levels? What other reasons could cause it.

We are both doing well I just want to know I’m asking the right things so we can fix whatever the problem might be for next time xxx

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Boo718 profile image
Boo718
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Millbanks profile image
Millbanks

Hi Boo, so sorry :(

I know it's hard, but I always felt that chemicals were a sign that your body is at least trying!

As it was a PGS tested embryo, there are a couple of things I would ask about checking;

1) the timing - if you're transferring to early or too late and missing the window of implantation then it may try to implant but just not be able to carry on. You can do an ERA test to check this (I did and mine was out by 24 hours).

2) Your immune response. Your body has to lower it's own immune system in order to accept 50% foreign DNA (your OH sperm) and it does that naturally normally. However for us IVF-ers, sometimes our levels are raised or they don't lower enough - and a low dose steroid can help your body do that.

3) Check progesterone levels - it's important that they are high enough during your 2WW

4) Blood clotting - you can test for Thrombophilia which means that your blood flow to your uterus isn't good enough. Blood thinners can help with this.

Good luck!

xx

Boo718 profile image
Boo718 in reply to Millbanks

Thank you soo much this is exactly what I’m looking for xxx

Millbanks profile image
Millbanks in reply to Boo718

If you have any questions feel free to pm xx

Boo718 profile image
Boo718 in reply to Millbanks

Thank you, I’ve been trying to jot down as much as I can think of. I had progesterone checked before transfer but not in the 2ww maybe they should check that next time incase it needs increased. I’m going to look up the era just now. I am on prednisolone and clexane but maybe not enough. This process is nuts xxx hope you are good xxx

Millbanks profile image
Millbanks in reply to Boo718

It sure is nuts! I think for us, combining a PGS tested embryo, with prednisolone (and clexane) plus the correct ERA timing was the winning formula. It's a process of elimination I think... xx

Boo718 profile image
Boo718 in reply to Millbanks

Can I ask how much clexane and prednisolone were you on? I’m on clexane 40 once a day and prednisolone 10mg ( it was 4 tablets for 4 days before transfer then down to 1 tablet) Then 800 cyclogest and 25 prolutex xxx

Millbanks profile image
Millbanks in reply to Boo718

Yes, the same clexane dose (although it was Inhixa brand), but I was on 20mg prednisolone 6 days before transfer, then up to 11 weeks (then tapered off). I also had an intralipid infusion the day before transfer. I was on 1200 cyclogest (3 a day) & 2 x lubion injections too. Was like a pin cushion!! xx

Boo718 profile image
Boo718 in reply to Millbanks

Wow that’s heaps. How did they know to put you on soo much progesterone? I do wonder if mine isn’t quite high enough. Thank you for your help. What’s an intralipid infusion? We live in Scotland which is a nightmare to get tests but doing ivf in Spain xxx even trying to get a blood test at home is a pain so trying to do everything we can before going home xxx

Millbanks profile image
Millbanks in reply to Boo718

Yes it is a lot! Historically I've always had low progesterone during transfers (and I used to have spotting before my periods which also indicated that my body didn't make it well enough either on it's own). But each transfer I'd have a blood test and each time it would be low. So they always gave me a high dose, then upped it on the day after transfer when invariably the results would be low again....

Intralipids are immune treatment: fertility-academy.co.uk/imm...

They were initally created for immunotherapy in cancer but a side affect was the lowering of the immune system - so began using it in fertility treatment.

The jury is very much out on whether it makes a difference or not but it was £250 for the one, so thought might as well throw everything at it!

xxx

PaulaDag profile image
PaulaDag in reply to Millbanks

Hi Millbanks, did you continue with intralipids after a positive pregnancy test? I’d heard you’re supposed to have one before transfer and then at 8,12 and 16 weeks xx

Millbanks profile image
Millbanks in reply to PaulaDag

I had one the day before transfer, one at 6 weeks and one at 8 weeks xx

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