Down reg blues

[NemoFish]

Has anyone else found down regulation really tough? I’ve just finished my third week of buserelin and my second 7-day course of norethisterone within that time and I don’t know what to do with myself. My mood swings are out of control. I can’t stop crying all day. I’ve got zero energy whereas before you couldn’t get me off my spin bike! I feel completely drained mentally and physically. My sleep is terrible too, I’m waking up throughout the night sweating and just worrying about everything and anything. The smallest thing can feel like the end of the world and I’ll just explode 😞

[Llizzie]

Yes. The nurse warned me it was the worst stage. Your hormone response is being dampened so it’s apparently a bit like being menopausal (when woman often take hormones to feel good again). I did feel better when I started stims - I could do a bit of exercise during that but none during downreg, I felt like a slug. It will pass x

[NemoFish in reply to Llizzie]

I really hope so, I feel so desperately sad and angry at the moment. My next scan is the 31st, if I can’t start stims then I’ll lose the plot completely x

[soccerkt6]

Yeah, I was waking up with night sweats during down reg, it was awful.It’s a shitty phase but like Llizzie said, it will pass. Hang in there, I’ll be thinking of you xx

[NemoFish in reply to soccerkt6]

Thank you, I feel so depressed right now amongst everything else I’m desperate to move on x

[soccerkt6 in reply to NemoFish]

Oh lovely, I’m sorry. I know when I feel depressed it feels like I’ll feel that way forever, but trust me, the depression is caused by the medication (not you!) and it will lift when you start stims. Be gentle with yourself for the next few days xx

[Patches86]

Me! Felt so depressed during downreg (synarel nasal spray) it was horrible, it was a very scary feeling. I felt much better once I started stims. I’m sorry you’re going through that now. X

[Catlady101]

Hi Lovely, I wrote a very similar question when I was on norethisterone a couple of weeks back. Drove me absolutely bonkers! Low mood, low energy, night sweats and awful sleep. The ladies on here reassured me that this stage was the hardest and thankfully they were right. I’m off them now and feel so much better. Good luck with your cycle, look after yourself xx

[MyPatronusIsACorgi]

Know exactly what you mean! Was due to start stims on the 2nd June but still haven’t had a bleed on the buserelin and was told I need to double my dose to try and trigger it. I feel overwhelmed and exhausted, and extremely nauseous all the time, injections are starting to hurt more and I tense up before I have to do them which doesn’t help either. Cramping in the sense I’m about to have a bleed but nothing is happening and I’m so worried that my EC is going to be delayed.

I’m probably being a wimp about it all but this is worst I’ve felt since I was severely depressed a few years ago i know it’ll all be worth it in the end but they’re definitely not wrong when they say IVF is a tough journey...

[NemoFish in reply to MyPatronusIsACorgi]

I’m so glad it wasn’t just me, I was starting to go back to that depressed state I was in during my 20’s and it was quite frightening at times. Really not nice at all. I got the go ahead to start stims a couple of days ago despite still having two cysts on my ovaries. I’m hopeful these feelings should go away soon. I hope you get your period soon and can move on from this horrid stage x

[MyPatronusIsACorgi in reply to NemoFish]

It brings me comfort that I’m not the only one who feels like this during this process. Think we’ve found a solution to stop me feeling so panicky for the night time injection, so fingers crossed I’ll be able to cope with it all (still no bleed again so it’s just a waiting game). Wishing you all the best of luck with your egg collection 🤍 thank you for your response as well x

[Fluffy21]

Hey I had buserelin and it made me think I was going crazy from all the symptoms but the good news was I got my eggs at the end of the long protocol and now take this into consideration in any fet plans. Make sure you are kind to yourself and look after you. Even when you think you can’t do it anymore...u will..because you are strong and will get through it😀

[Maybebaby008]

I totally felt like this. I felt so low. Like my life was in limbo and nobody understood. Decided I hated the process and was never doing it again. Often disliked my husband a lot too through no real fault of his own. Got to say once I stopped the buserelin I felt much better. I’m 2dp5dt today and feel so much more like myself now so hang in there! I was down-regging for over a month so it felt like such a long process.

Good luck to you. X

[Patches86]

Totally me - I was on Synarel and have never felt so depressed in my life. Much better once I started Progynova.