Ideal Progesterone Levels?

[MD123]

I had a fresh transfer on 22 March and had a very faint positive on test day and the few days after, by 14dp5dt the line was nice and strong.

Blood result at 14dp5dt - hcg 62 and Progesterone 45.9

Blood result at 16dp5dt - hcg 133 and Progesterone 17.9

Although Progesterone remained in the 'normal' range, the drop scared me, especially after having bled before 6 weeks in my 2 pregnancies last year and ultimately losing them both.

I had been on lubion support until 13dp5dt which I guess is why the first result is so high but I had been self medicating with pessaries at 3 per day since it ran out as Progesterone was a worry in my mind.

I have got more Lubion from the clinic but they are most unhelpful and don't believe in monitoring Progesterone. My GP surgery is great and will help in any way they can (thank goodness) so I just wondered if anyone is 'in the know' from their clinic as to optimal Progesterone levels to aim for? I don't want to overdose, as my clinic were quick to tell me the link between too much and Autism... 🙈

Thanks in advance!

[N-A-58]

Above 80 on the day of transfer so I’m told and have read. Should stay above that as the days go on.

[sunset212]

I think you should have a chat with your clinic as soon as you are able to as progesterone shouldn’t really be dropping as pregnancy progresses but it’s good they have now reinstated your Lubion injections.. You need some support there. My clinic likes to see above 50 pmol/L on day of transfer and should remain consistent as pregnancy progresses and rise as the weeks progress. I read a minimum of 15 ng/L ( roughly 50 pmol/L) is needed to sustain a very early pregnancy in the first few weeks. I had my progesterone measured myself when I reached 12 weeks + 6 days and had stopped the pesseries and mine was 123 pmol/L which was equal to approx 38 ng/L.

Another point to note is progesterone levels can fluctuate in little pulses throughout the day and so it’s best to get a morning reading both for consistency, there does however seem a rather large drop after only 2 days. Are you still taking the cyclogest pesseries alongside the Lubion? Best of luck and congrats on your pregnancy news x x

[Mellyboo111]

It is low but not that low from where you need to be. I did my first test 9dp5t and progesterone was 19 something. My doctor said he wanted it over 20 so he increase the progesterone from 1cc to 1.5 cc, which increased my progesterone to 23. Then two weeks after he increased progesterone to 1.7cc. A week ago i did my first 6 week scan and my progesterone came back at 30 something and he said 30 was good so he did not increased my progesterone shot. I would say you should increased progesterone but not by alot so has to not overdose. Maybe you can used mine to help you on how to increase. Good luck

[Sweatsour]

Hi there, I was taking cyclogest 400 twice a day for 10 weeks. Never heard about link between progesterone and Autism! Where did they get this information from?? Best of luck. I hope your pregnancy will progress well.

[Cinderella5]

I'm only really aware of progesterone levels for transfer which my clinic like to be over 60nmol/l. I've never heard of progesterone being linked autism and even if it was I think it would have to be super high as I know some clinics like their levels over 100nmol/l. I'm glad that you've gotten more lubion, I really do this its been key for me after my history of bleeding and spontaneous loss. I think so long as your levels go up then that's the main thing. I was on lots of lubion this time around, 2x400mg of cyclogest plus 2x25mg of lubion and in hind sight if had been needed it I would do progesterone oil injections for future. Good luck.xx

[Verdi]

Many congratulations on your BFP, and hope your pregnancy is a healthy one! Sorry for the long post, but I’m hoping you might be able to help me out.

I had a Fresh BFN in Jan 2018 (2 x Cyclogest), bled from 8dp5dt. BFP from Frozen transfer in July 2018, (1 x Lubion) this resulted in my 2 year old.

Now we are trying for a sibling and had a BFN from a FET in October 2020 (1 x Lubion, bled 9dpFET) and BFN from final FET Jan 2021 (1 x Lubion + 1 x Cyclogest but didn’t bleed until a few days after I stopped Progesterone).

I had EC yesterday, and consultant said I could do what I liked with Lubion/Cyclogest, so had been planning on taking one of each every day. However, I have since read that too much progesterone on day of ET could possibly be counterproductive, so now I’m not sure! Did you start your Lubion and 3x Cyclogest immediately after EC? Thanks in advance!

[MD123 in reply to Verdi]

Unfortunately I had a bleed and the pregnancy was over last week.

I was put on 2 lubion injections per day by the clinic from the day after egg collection. On transfer day, I was worried and started adding in extra cyclogest as well. From blood tests I have had, I feel like the Lubion brought my levels above 50 and then when it ran out after 2.5 weeks, my levels plummeted, despite being on cyclogest. I just feel like I don't absorb cyclogest well at all and in the future, I will definitely go for the Lubion twice per day

[Verdi in reply to MD123]

I am so so sorry to hear this MD123 😢 - thank you so much for replying at such a difficult time and I wish you every success in your next cycle. Xx