What is the significance of R.I.S.C. (Relationship between Insulin Sensitivity and Cardiovascular disease) test for diabetics?

Former Cadbury CEO and diabetic Ashok Jain has made RISC tests available all over India... you can read his story here..


What is the significance of R.I.S.C.


R.I.S.C (Relationship between Insulin Sensitivity and Cardiovascular disease)test helps to determine how much risk patients are at for being diabetic and if patients are diabetic,it helps in measuring various risks associated with the disease.

The primary objective of R.I.S.C is to establish whether insulin resistance predicts the deterioration of CVD(cardiovascular disease) risk markers,diabetes,obesity, atherosclerosis,dyslipidaemia and clinical CVD.

Secondary objectives are:1) to analyse genetic and environmental contributions to insulin resistance and CVD and 2) to develop and validate a method for the assessment of insulin sensitivity based on the oral glucose tolerance test.

It measures various vital health indicators that would indicate the level of insulin resistance and extent of development of cardiovascular disease and diabetes mellitus.Overall it is a good test to know health status and disease progression of diabetes mellitus.

Last edited by

4 Replies

  • Something loaded and too informative; comes from pioneering work of Dr Kraft and related to "insulin" and health :

    Analysis from a Chemical Engineer:


    More on this:


    Since no mainstream doctor ever focuses on insulin tests, not many care to look for it. Also explains why we focus on insulin levels while we talk of diabetes management. Any approach that looks at bumping residual insulin in blood to reduce blood sugar in T2, we prefer not to touch even with a 10 foot barge pole. Cutting carbs helps more than taking statins for CV issues. Even OGTT fails to cover everything.

  • cure


    arey yaar. It's all the same except attractive terminology. I don't think insulin has anything to do with cvd chd directly. It's the bs levels that are important. All such terminology is like an attractive wrapper to sell items. It's the same as we recommend to t2d patients.

    1) knowing D status by bs, s. Insulin and a1c estimation. This gives information about ir.

    2) tests to find collateral damage due to uncontrolled bs levels.

    What we talk is real science. We practice it and preach it. These people have to use such attractive terminologies to get more funds and in turn those who give funds come up with new costly tests.

  • But, what if insulin is maintained high and blood sugar controlled as a result of use of medications to cover a bad diet? I think, both need to be looked at. Elevated insulin levels is also a big problem.

  • Anup

    insulin sensitivity is in inverse proportion to ir. We are talking about ir.

    But there are few conditions when insulin is elevated and bs under control.

    1) prediabetics.

    2) on P whipping drugs.

    I don't think they are having more risk than those who have uncontrolled D.

    There is third category also.

    3) obese people. They have raised insulin levels. Conked insulin response. I don't know if they have higher risk of cvd chd than the D people. But highly obese people - morbidly obese have many other associated problems like respiratory.

    Ok. Fine. If someone believes that high insulin levels can cause chd cvd then he/ she has to explain the mechanism of its independent action.

You may also like...