Do you balance methylation?

[faridaro]

Came across the following statement on Seeking Health website - link to the article

seekinghealth.com/blogs/edu...

"Increased methylation may also negatively impact neurotransmitter production, such as dopamine, norepinephrine, and serotonin while increasing acetylcholine. During methylation, S-adenosylmethionine (SAMe) plays a key role, and its overproduction can trigger symptoms, including the following:6,7

Tremors and inexplicable shaking.

Skeletal rigidity.

Hypokinesia and the slowing and decreasing of body movement.

This is why understanding and maintaining balanced methylation is crucial to supporting your overall health."

And there is advice:

"If you or a loved one are struggling with these challenges, here are some actions to discuss with your healthcare professional to support wellness and methylation balance.:

Avoid high-methionine foods: Temporarily reduce your intake of methionine-rich foods to prevent excess SAMe production.

Pause folate and B12 supplementation: Certain prescription medications that contain folate, as well as over-the-counter supplements like methylfolate and methylcobalamin, may need to be paused under the direction of your healthcare professional.

Incorporate these supplements from Seeking Health™ to lower homocysteine into your diet:

P-5-P (Pyridoxal 5-Phosphate) helps lower homocysteine and converts it into vital nutrients such as taurine, cysteine, sulfate, and glutathione. These nutrients are essential for healthy neurological function and the body’s normal protection from oxidative damage. A deficiency in active vitamin B6 may explain some of the symptoms you're experiencing.†

Magnesium Plus combines active vitamin B6 and magnesium, which may further support this process. Consider consulting your healthcare professional to determine the appropriate dose.†

Niacin: A small dose of niacin (20–50 mg, 2-3 times daily) can help by "eating up" the excess methyl groups that might be causing your homocysteine imbalance. You may find support by including niacin as part of your regimen for temporary methylation balance.†

These recommendations should be tailored to your unique healthcare status, and it’s wise to consult a healthcare professional who’s well-versed in MTHFR and methylation issues. "

Personally I have heterozygous C677T MTHFR variant and wonder if anybody here has been looking into balancing methylation status beyond monitoring homocysteine levels which I've been doing already.

[LAJ12345]

my husbands dna test advised against methylated vitamins. Interesting.

[bookish]

Hi, firstly I should say that I don't have PD, but other neuro issues. I do pay attention to methylation, but not solely to MTHFR. There is a lot of overblown hype about that which makes doctors keen to dismiss the whole area, which is a pity when it is possible to make a considerable difference. If you look at SNPs across folate and methylation cycles - one carbon metabolism - then balancing those may be very helpful. This is complicated, and involves some trial and error. If I'd only looked at my, like you, hetero C677T MTHFR then I'd have assumed that methyl groups would make me worse, but I'd already found that methylfolate was hugely helpful, along with magnesium, prior to doing the testing. So when I looked at the whole area, I found that I had slow COMT, which for me seemed to be a greater influence on overall health than the MTHFR was being. So do plenty of reading and take it slow, but worth pursuing, in my opinion. Cheers

[faridaro in reply to bookish]

Thanks for sharing your thoughts. I'll have to dig into my genetic report to see other variants but not sure if I'd be able to make sound judgement regarding metabolic cycles as they are too complex for my PD brain.

[bookish in reply to faridaro]

No problem. I agree that this is complex and of course looking genetically only gives you a predisposition, as the SNP still needs to be expressed, and many don't, and won't. You could try a functional practitioner with particular experience, such as Nancy Mullan and I am sure there are others.

[MarionP]

How is one in practical terms to even know and measure?

[faridaro in reply to MarionP]

Exactly my sentiment!