Tryptophan & Niacin(B3) Relationships - Cure Parkinson's

Cure Parkinson's

26,583 members27,899 posts

Tryptophan & Niacin(B3) Relationships

Kia17 profile image
26 Replies

“Your body needs essential nutrients in regular amounts in order to continue to function properly. Of these, the amino acid tryptophan and the vitamin niacin share a special link. These two nutrients have different properties and fulfill very specific roles in your body’s biochemical processes. In addition, a deficiency in either one of these chemicals can lead to negative health effects.”

livestrong.com/article/4293...

Written by
Kia17 profile image
Kia17
To view profiles and participate in discussions please or .
Read more about...
26 Replies
bassofspades profile image
bassofspades

The 5-htp form of tryptophan is a direct pterosaur of serotonin.

Kia17 profile image
Kia17 in reply tobassofspades

Bass,

How much 5-Htp have you been taking? I think it’s a part of your amino acids programme?

As far as I know, the 5-htp and SSRIs reduce the amount of Dopamine. Any thoughts?

bassofspades profile image
bassofspades in reply toKia17

I take a total of 150mg 5htp per day divided into two doses. Yes serotonin competes with dopamine for amino acid precursors, according to Hinz, but somehow his protocol, with the various cofactors, balances it out. Probably with tyrosine. Hinz has a paper on the competitive inhibition theory that explains it. Its easy to find on Google. Edit: see link in reply

I wouldn't take an SSRI because that doesn't solve the underlying problem (depression anxiety caused by deeper subconscious issues). The symptoms it "cures " will reappear in another form, according to Dr John Sarno.

Kia17 profile image
Kia17 in reply tobassofspades

Thank you Bass

bassofspades profile image
bassofspades in reply tobassofspades

ncbi.nlm.nih.gov/pmc/articl...

Everyone with pd should read this.

LAJ12345 profile image
LAJ12345 in reply tobassofspades

Thanks. That is so interesting. How long / how many rounds of testing did it take to settle on what amino acids you should take? Does the dose stay constant once you have found the right level or is it constantly changing?

It sounds like it isn’t a good idea to take the c/l or even the mucuna without knowing how much of the other precursors to take.

bassofspades profile image
bassofspades in reply toLAJ12345

For me, we used what is called the pill stop method to test for the proper dose. We got it in 3 weeks and im still on the same dose since then. Its been 13 months. Recently i was feeling so well that I tried to reduce the amount by 1/3 but my symptoms came back within a week.

Unfortunately the dr that set me up recently passed away. He saw me twice in the office then we did the rest over the phone.

Kia17 profile image
Kia17 in reply tobassofspades

Bass,

Please can you share with us the cost of your Amino Acids treatment?

Thank you

bassofspades profile image
bassofspades in reply toKia17

Sure.

Neuro replete 2 per day $29 for a bottle of 60 pills. $15/ month

Mucuna 6 pills per day $18 per bottle of 120 pills $27 per month.

Cysteine 6 pills per day $18 per bottle of 250 pills $13 per month

$55 per month total.

It is my understanding that I am on a lower than average dose.

KERRINGTON profile image
KERRINGTON in reply tobassofspades

Hello, do you think these supplements enhance the thiamine protocol, and which strength mucuna are you on ?

Thanks

bassofspades profile image
bassofspades in reply toKERRINGTON

166mg mucuna yielding 100mg L-dopa per capsule. I take thiamine too, 3000mg per day and i would say my aminos do the majority of the therapy but the thiamine helps very much as well.

I started with a UPDRS score of low 30s. Amino acids took it down to low 20s. Thiamine took it down to mid teens. Now i am treating myself for TMS tension myoneural syndrome, and this therapy has taken my score all the way down to about a 3. The therapy involves reading books by Dr John Sarno and working out my subconscious "rage" through journaling. Had i known about tms when this all began, i think i never would have gotten pd. I know that is a strong statement but if you learn about it you will understand. And if your PD is of idiopathic origin and came on suddenly with no known cause, then you may benefit from this as well. Once i hammer out the details in my head I will post a nice detailed post on this. I have touched on it over the past week. I will say in addition that serotonin is involved as well, according to what I am learning

Kia17 profile image
Kia17 in reply tobassofspades

Bass,

Have a look on this link;

curablehealth.com also can get it on App Store too.

Its based on Dr Sarno’s theory.I got free version and now signed up for a monthly subscription. It looks a very good app.

bassofspades profile image
bassofspades in reply toKia17

I actually tried that app just last night. I didn't like it. The book is all you need. The divided mind by John Sarno. And Nicole Sachs' YouTube videos. I might get her book too.

Kia17 profile image
Kia17 in reply tobassofspades

Thanks for your input.

LAJ12345 profile image
LAJ12345 in reply tobassofspades

thanks for all this information. I am finding it most useful.

Kia17 profile image
Kia17 in reply tobassofspades

Many thanks Bass

bassofspades profile image
bassofspades in reply toKia17

Thank you too my good friend!

in reply tobassofspades

How do you factor diet into your supplementation regime? Diet is presumably not a constant.

bassofspades profile image
bassofspades in reply to

Go as much organic and paleo as you can. Low carb as best as you can too. Nobody's perfect but do your best. Timing of proteins and meds does not matter. Intermittent fasting is a good way to go too.

in reply tobassofspades

So you may be supplementing when you could get diet to relieve that burden or when it is already supplying your needs. Organic, paleo and low carb is also a combined dietary burden. If you are not carrying excess body fat there is also the issue of taking onboard sufficient food groups so as to provide for ketosis without attacking the body’s musculature.

MBAnderson profile image
MBAnderson in reply to

Would you please elaborate some on this?

Is low-carb a dietary burden?

Are you saying we can be in ketosis without low-carb?

bassofspades profile image
bassofspades in reply to

Osidge im not sure i understand what you're saying.

Niggs profile image
Niggs in reply tobassofspades

Sorry if I sound like a stuck record, but I thought I'd mention again I get the same 'very negative' reaction to too much agonist 'and' any serotonin supplementation whether ssri or 5-htp which is in line with Swedish research suggesting anxiety is caused by too much not too little serotonin.

This in my experience confirms a dop/ser relationship and possibly the reason stress makes pd so much worse and why so many of us were dx'd after chronic high level stress,

perhaps we just needed a reduction in serotonin but instead were put on the dopamine treadmill.

Kia17 profile image
Kia17

Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism

nature.com/articles/npp2015...

JANVAN profile image
JANVAN

Thanks !!

Do you know a good branch of niciosamide riboside ??

Kia17 profile image
Kia17

Janvan,

I personally take Tru Niagen from ChromaDex

Not what you're looking for?

You may also like...

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

Niacin PD patients are found to have significantly decreased niacin levels compared to age-matched...
Farooqji profile image

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

"Future studies should study the effects of long-term supplementation of promising nutrients,...

Upping My Niacin to 1000 mg

Update: I just learned there is an increased risk of diabetes on niacin therapy:...

Tryptophan vs L-tryptophan, which is best?

I have long had a sneaky suspicion that serotonin is more important for me than dopamine. So now I...
gomelgo profile image

How to Take Niacin Without Getting Diabetes

I just learned there is an increased risk of diabetes on niacin therapy:...
Bolt_Upright profile image