Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

[Bolt_Upright]

Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy 2020 sciencedirect.com/science/a...

To read the full article click on the PDF link on the page.

"NAD + is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD + depletion occurs in patients with degenerative disorders and whether NAD + repletion improves their symptoms has remained open. Here, we report systemic NAD + deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD + - booster niacin, a vitamin B3 form (to 750–1,000 mg/day; clinicaltrials.gov NCT03973203) for patients and their matched controls for 10 or 4 months, respectively. Blood NAD + increased in all subjects, up to 8-fold, and muscle NAD + of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidence indicates that blood analysis is useful in identifying NAD + deficiency and points niacin to be an efficient NAD + booster for treating mitochondrial myopathy"

So... Google tells me: "Mitochondrial myopathy is a progressive muscle disease caused by damage to the mitochondria"

And Google also tells me: "Mitochondrial dysfunction is a key feature of Parkinson's disease (PD) and is thought to be a major driver of the disease".

The Mitochondrial myopathy study used 750 to 1000 mg of Niacin a day. I take 2000 mg. I don't have a good reason for going to 2000. The NOPARK study used 1000 mg of NR and then 1200 mg in open label after the study. At some point I decided the BOLTPARK study would use twice as much.

I also take one of these every day (something to do with methylation and not raising homocysteine levels): L Methyl Folate 15mg plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive forms of Vitamin B9 & B12 amazon.com/gp/product/B0938...

[Steegen]

Very interesting, thanks for posting. From all I've read, niacin is very beneficial to PD. Do you believe niacin is helping you with reducing incidents of RBD?

Also, do you know if it affects your blood sugar at all?

I find niacin helps me feel better, but in my case it seems to give me vivid dreams and nightmares, and disrupt my sleep. I read one study where it helped a PD patients symptoms, but also gave him nightmares.

(for background, I have a neurological condition which is being investigated, but believe I have RBD or something similar, but as yet haven't tested it with a proper study)

[Bolt_Upright in reply to Steegen]

I do a lot of things, so I can't know for sure if Niacin is helping. I know my high school educated brain thinks it is a key part of my protocols. I think it is important to take L Methyl Folate too.

As for blood sugar, I have read that it can raise blood sugar and somebody on this forum was taking 2? grams and their blood sugar went up. I drink Pepsi (only with real sugar) all day and seem fine. I also take Berberine, which is kind of like a natural Metformin, and that may be helping my blood sugar.

My RBD used to be a real nuisance, falling out of bed, punching the wall, throwing pillows. Now it is almost non-existent. Usually the most I do is say a few words as I am waking up in a dream. This is my stack: rbd-pd-protocols.blogspot.c...

[Steegen in reply to Bolt_Upright]

Thanks for the reply

[TL500 in reply to Bolt_Upright]

What is rbd? Thanks

[Bolt_Upright in reply to TL500]

Rem Sleep Behavior Disorder. Fighting in your sleep. Most likely prodromal PD.

[TL500 in reply to Bolt_Upright]

Thanks

[MarionP]

It's a good idea. At least the idea of it being one of the contributors seems justified enough to continue research into it as a cause. It means b1, b3, b9, and perhaps coenzyme Q10 supplementation might be of help, probably couldn't hurt. If you have Parkinson's or parkinsonism and the supplementation idea pans out with evidence, someday, then perhaps you might just help slow down the progress... If you don't have PD, then you might help prevent or delay PD onset. Reversal? That's a big question, you would have to still have some dopamine producing cells alive and able to grow back with the right supports. Or the brain have some way of getting new such cells, maybe stem cells under research.

Also dietary, eggs and animal meats, fish and such proteins could help a lot, maybe a bit of L-tyrosine, and good a good amount of exercise including vigorous exercise of some kind.

Now this is the kind of thing that suggests it might be legitimate and even valuable to start a prospective longitudinal study with people at pre, early, or prodromal (roughly symptom free) stages and do a regimen and follow them for some years. And of course nothing the matter with doing such a regimen yourself, and who knows maybe whatever you have won't get much worse even if it isn't positive proof. I like the idea very much, it's not at all a bad way to go in the meantime and it's very doable. Except the stem cells part of course.

[Bolt_Upright in reply to MarionP]

One thing we learned from the Augusta study (250 mg NA) was they were targeting GPR109a. NA binds with GPR109a.

I won't pretend to understand this, but a quick Google on GPR109a:

GPR109A, or G protein-coupled receptor 109A, is a receptor that's involved in a number of processes, including:

Gut health

GPR109A is a receptor for butyrate, a bacterial product that helps repair damaged tissue, maintain gut homeostasis, and regulate immune responses. GPR109A also helps protect against colonic inflammation and carcinogenesis.

Niacin

GPR109A is a receptor for niacin, also known as vitamin B3 or nicotinic acid. Niacin is a pharmacological agonist for GPR109A, and has been shown to suppress colitis and colon cancer.

Lipid metabolism

GPR109A may sense gut and liver metabolites, and modulate cell signaling related to energy and lipid metabolism.

Vascular inflammation

GPR109A may be involved in vascular inflammation. Niacin may act directly on monocyte/macrophage function through GPR109A, which could lead to plaque regression.

[MarionP in reply to Bolt_Upright]

Just another reason to give it a try. Unless you overdo it, it probably wouldn't hurt.

[Bolt_Upright in reply to MarionP]

The recommended daily amount of niacin for adult males is 16 milligrams (mg) a day. I take 2000 mg. I think my doctor would say I am overdoing it (except that I mentioned to him what I was taking and he did not seem concerned at all).

[karter1 in reply to Bolt_Upright]

How do you control the flush response with that high of a dose?

[Bolt_Upright in reply to karter1]

I worked my way up to that dose. You can have some food with it. I like the flush.

[JayPwP]

⚡

You have now surpassed your high school degree 😜😜😜

[Gallowglass]

thanks! I’m unclear: do you take plain niacin and if so what brands?

[Bolt_Upright in reply to Gallowglass]

I take this: Rugby Niacin 500mg - Vitamin B3 Supplement for Men and Women - 1,000 Tablets amazon.com/gp/product/B003H... It is Nicotinic Acid.

I also take one of these every day: L Methyl Folate 15mg plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive forms of Vitamin B9 & B12 (60 Capsules) amazon.com/dp/B0938NKV1G?re...

I have a high school degree and poor impulse control. I am prone to take risks. Please do your own research.

[Mezmerric]

thanks for sharing. Useful to know.

[Jojaku123]

Thanks! So would this be a more effective supplement than Tru Niagen, which contains nicotinamide riboside chloride?

[Bolt_Upright in reply to Jojaku123]

I can't say that. I can't say if either is effective. All I can say is my high school educated brain can't see why NR would be better than NA.

[popo1]

i've just searched for the NOPARK study and it appears they've extended it 2 more years AND added the NADAPT study for application to other neurodegenerative diseases; i.e. MSA, PSP...

should we take this to mean it failed or worked?

either way - i'm restarting it as NAD+ is a precursor to ATP(food) and i didn't have anything for feeding the mitochondria in my current stack; only anti-inflammatory's, neural protectives and regeneratives. but no food. i took one, 1.6g, yesterday afternoon and quickly felt a boost.