Increased level of homocysteine, what to ... - Cure Parkinson's

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Increased level of homocysteine, what to do....??

dadcor profile image

The “Gold Standard” to decrease the elevated homocysteine levels is to use the combination Folate+B12+B6.. Presuming Folate may be cancerogenic (esp. Prostate cancer..), B6 is not recommended due to Ldopa interference .., than what remains as the main weapon against increased levels of homocysteine, only B12..??

How about if Folic acid may alternatively be administered as 5-methyltetrahydrofolate, is it safe..?? .Advises will be much appreciated..

11 Replies

Not sure, but have read that coconut oil shrinks the prostate. Does the shrinkage also reduce the chances of prostate cancer?

Dear dadcor,

I hope the following article helps you understand the balance of B complex vitamins when used in combination with levodopa treatment.

MBAnderson profile image
MBAnderson in reply to Nhalvo

Thanks. Good article.

Hidden profile image


Synbiotics lower homocysteine, while raising glutathione! If that isn't enough, synbiotics lower inflammatory mediators known to be overactive in PD while lowering oxidative stress both of which are helpful for PWPs! If that isn't enough, synbiotics help to repair leaky gut while increasing insulin sensitivity of which both processes are anti inflammatory. If that isn't enough, synbiotics are neuro protective while also improving thiamine and vitamin D status. If that isn't enough, synbiotics lower high sensitivity C-Reactive Protein (hs-CRP) while reducing or eliminating constipation! If that isn't enough, synbiotics can raise dopamine levels while reducing depression and anxiety!

Holy crap, where can I get these synbiotics?😁😁😁

I can go on, but I discussed most of this and more here:


dadcor profile image
dadcor in reply to Hidden

Holy sh.., where can I get these synbiotics? Which is the right one..?? :)

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Hidden in reply to dadcor


I believe Gio has found a good one and possibly Kia. But there are many on line or you can go the fermented food route which are generally fairly broad spectrum and in large numbers of bacteria.


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I think it is fixed now!☺️😇😇😇

5mthf would be preferable source of folate. Methyl b12 also preferred b12. B6, b2 choline or trimethylglycine helpful. Also creatine and phosphatidyl choline r 2 major uses for methyl groups so taking them can support lower hcy. Plus we lose about 2 grams of creatine daily. Athletes lose more.

A very good article from 2009:

See also:

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress.

L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra.

Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease.


Nutrition and Nonmotor Symptoms of Parkinson's Disease.