Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson’s disease

[PDWarrior1900]

mwhp.com/methylene-blue-and...

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I never heard of "methylene blue" until 15 minutes ago while watching this Dr. Berg video.

He says you can buy it over the counter!

youtu.be/dDUZ0ODBfJs(Not working as expected?)

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Here's a thread about methylene blue and PD:

parkinsonsnewstoday.com/for...

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and I found methylene blue on Amazon, about $30.

amazon.com/Methylene-Labora...

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Methylene Blue Protects The Dopaminergic Neurons through Upregulation of BDNF

faseb.onlinelibrary.wiley.c...

[Manypony]

I used it faithfully for months, no noticeable effect

[PDWarrior1900 in reply to Manypony]

thanks for the feedback

[park_bear]

This study:

Methylene Blue Protects The Dopaminergic Neurons through Upregulation of BDNF

used pretreatment which is not a valid model of PD. Details here:

healthunlocked.com/cure-par...

[pvw2]

Note: it has an interaction with rasagiline, a PD medication: my.clevelandclinic.org/heal...

[Bolt_Upright]

It is much much cheaper to get the pharmacy grade powder. About 5 grams for about $50 on Amazon. You can mix it 1 gram to 100 ml distilled water for a 10% solution. Lots of info on this old thread: healthunlocked.com/cure-par...

[chartist in reply to Bolt_Upright]

If you have stone countertops, cover them because methylene blue will stain them and anything else it touches.

Art

[SilentEchoes in reply to chartist]

Lemon juice reduces the MB and it becomes clear. Don't do this on marble.

[chartist in reply to SilentEchoes]

It does, but I think the combination may be creating a different chemical that may not have the same exact effects as MB?

Art

[SilentEchoes in reply to chartist]

No, read my other comment on this post.

[chartist in reply to SilentEchoes]

Okay I read your other comment. My question is does this change the effectiveness of methylene blue in terms of known health effects that people take it for? Can you link to something that discusses this? I would be interested in reading it, because I have heard of people using ascorbic acid for this purpose, but never read anything about any alterations in effectiveness.

Art

[SilentEchoes in reply to chartist]

"does this change the effectiveness of methylene blue in terms of known health effects that people take it for?"

The short answer is no.

I researched MB for methemoglobinemia, my red cell count is high. rMB had a remarkable effect and my hemoglobin and hematocrit are in the normal range. My blood doesn't look brown anymore and my lips aren't blue. I was looking for an antidote to cyanide poisoning, rMB with high dose B12 (hydroxycobalamin) was in my reach.

People with G6PD should not take MB, and substitute high dose IV Vit. C and B1 instead.

I saved a video and want to do a writeup on it, but I just got out of the hospital and need to recouperate.

[Bolt_Upright in reply to SilentEchoes]

Thanks SE, I hope you are doing better! You are always in my prayers.

[Bolt_Upright in reply to chartist]

Or you could do like I did and marry an artist who does not care about blue stains in the kitchen

[Bolt_Upright]

youtu.be/dYlTsQNP5iM(Not working as expected?)

[MBAnderson in reply to Bolt_Upright]

I am also against having green pee.

[Bolt_Upright in reply to MBAnderson]

Embrace change!

[MBAnderson in reply to Bolt_Upright]

my apology if I sounded too harsh

[Bolt_Upright in reply to MBAnderson]

You are perfect Marc!

[SilentEchoes in reply to MBAnderson]

I add 1/2 tsp of Alkalini C to a juice glass with water and MB, the acid converts MB to the reduced form - more bioavailable. Not very noticeable in urine.

[Bolt_Upright in reply to SilentEchoes]

Alkalini C, now that is top shelf!

[SilentEchoes in reply to MBAnderson]

All the cool kids are doing it 😊

[Bolt_Upright]

Methylene Blue is Neuroprotective After Ischemic Injury (Mouse Study) Dr Been: youtube.com/live/Irh5Fgi8kA...

[Bolt_Upright]

youtu.be/LwXszYVNwa4(Not working as expected?)

[Bolt_Upright]

youtu.be/BmSUlYePGtE(Not working as expected?)

[PDWarrior1900]

great stuff you posted, bolt, thanks! i quickly reviewed that old post which says you are taking MB ... are you still taking it?

[Bolt_Upright in reply to PDWarrior1900]

I took it for awhile, then I stopped for a long time, then I started again a few months ago. It was kind of a pain in the arse when I first took it as I was measuring it into 4 ounces of water each time. Now I do like that lady in the video and just squirt some in my mouth. I found 10 squirts from an old CBD bottle twice a day makes my pee turn green some of the time. According to the Doctor Been videos you want to be on the low side and I am pretty sure that is where I am (but I could be wrong. I have a HS degree. I just figure that since my pee is not ALWAYS green I am not getting too much [which could be bad science]).

[PDWarrior1900]

how are you feeling after taking butanetap?

[MBAnderson in reply to PDWarrior1900]

It's only been 11 days, but so far zip, nada

[PDWarrior1900]

ok, i'm crossing my fingers, pal

[Gigi216]

My experience with methylene blue was quite negative I hope y’all have better experience. Everyone is different so perhaps that was just me. I read all the very positive videos and articles and so I decided to try.

[MBAnderson in reply to Gigi216]

care to elaborate?

[Gigi216]

I took it when I was sick with covid. Ari Whitten did a video saying it could help so I ordered some to have on hand. I didn’t take it the first time I got covid but I decided to try it the second time. I took it first 5 days and rapidly got very symptomatic, my husband also. My husband had to go to hospital I chose to stay home. I had excessive phlegm in my throat and felt I was suffocating. I can’t swallow well so that hindered me from clearing it. Anyway I took it one morning and immediately got worse. It clicked that it was harming me. I didn’t take any more and slowly got better over the week. I feel if I had continued it I wouldn’t be here. My husband had to be intubated and did not survive. Like I said I’ve read articles about it where people say they have done very well and love the benefits, I personally did not have that experience

[MBAnderson in reply to Gigi216]

I'm sorry for your loss.

Good thing you stopped when you did. (A constricting throat is some times an indication of an allergic reaction.)

[SilentEchoes in reply to Gigi216]

You need to test yourself for G6PD deficiency. MB is contraindicated if you have the mutations.

I am an unaffected carrier. No ill effects.

duckduckgo.com/?q=g6pd&ko=-...

[Gigi216 in reply to SilentEchoes]

Thanks for that information! I do have anti trypsin deficiency but I’m not sure about G6PD

[Gigi216 in reply to SilentEchoes]

Looks like Metformin, aspirin, soy, several herbal supplements are contraindicated. Looks like list is fairly long. It causes glutathione to be depleted in blood cells and hemolysis occurs. Vitamin K can also potentially cause. Thanks again I’ll definitely be looking for a complete list of what to avoid

[SilentEchoes in reply to Gigi216]

I wonder how many people with thyroid disease also have neurodegenerative disease. My hypothesis is there's a shared hypothalamic injury. My hypothyroidism is "central" meaning it isn't autoimmune. I have hyperinsulinemia, that I still don't understand and was prescribed metformin. Not going to use it. Managing it with Keto/Paleo diet principles. Again this is central diabetes (insipidus).

[Gigi216 in reply to SilentEchoes]

Yes it seems as long as thyroid is well treated this shouldn’t be an issue, I am so grateful you mentioned it!! This explains a lot of unusual symptoms I’ve had when trying supplements. Seriously thank you so much because I have severe anemia at the present I’m trying to improve now I know better what to avoid etc 🙏🏻

[Gigi216 in reply to SilentEchoes]

Thyroid hormone increases G6PD enzyme activity

academic.oup.com/endo/artic...

I have pretty bad hypothyroidism so I’m sure my enzyme activity is low

[Gigi216]

Thank you. Yes perhaps it was with me, I have several allergies

[SilentEchoes]

"never mind that the FLCCC is a group of political anti vaxxer quacks"

This rhetoric is getting really old. Please stop.

[PDWarrior1900]

youtu.be/mHB3CUV7ENI(Not working as expected?)

[PDWarrior1900]

this ND repeatedly says to check with your doctor before taking methylene blue ...

6 minute mark -- this ND talks briefly talks about how MB does "seem" to have some neuro-protective components to MB... and more ...

11:45 mark -- a few more seconds on 'maybe' MB helping with neuro-degenerative diseases...

12:10 second mark -- "anything messing with dopamine or serotonin you need stay away from MB" ...

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youtu.be/toAHzvWY99g(Not working as expected?)