One Month into Methylene Blue

[Bolt_Upright]

Edit 3 June 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

================

So I am one month into Methylene Blue. I take about 10 mg a day.

I have not been diagnosed with PD. I have REM Sleep Behavior Disorder and a poor sense of smell and a sore left shoulder and sore left leg and frequent/occasional involuntary movements. I also take SSRIs, which some literature says you should not be using if you are taking Methylene Blue. Do your own research on that and reach out if you want to.

Is MB helping? I don't know. I take a lot of things. My sense of smell is noticeably better (maybe that is just springtime). My face dandruff and dandruff has almost totally gone away (those flakes falling off my face always brought me down). Significantly reduced involuntary movements. Fine motor seems better. And my sore left shoulder used to ache all the way down to my upper forearm, but now the ache only makes it two thirds of the way down my upper arm. All subjective stuff. Maybe it is the regular waxing and waning.

I wanted to share some things I learned:

Cheap MB: USP Grade Methylene Blue Powder - 5 gm (mine came in 5 separate 1 gram vials. Sweet. Also includes a measuring thingy for once you have a liquid) amazon.com/gp/product/B08JL...

How I mix and measure: One gram of powder into 100 ml of water means each ml of water has 10 mg of MB. So I took a little jar and put 100 ml of water in it (I used tap water. Not sure if that is optimum, but it seems to work) and I marked the 100 ml line with a rubber band (in hindsight I really did not need to do that, but I kind of like it). I added one gram of powder to the water, put the lid on and shook it up, and presto! I have MB juice! Then I have another little 4-6 ounce jar I drink out of. I put water in that jar, and then use the suction thingy to get 1 ml of MB out of my MB jar and squirt it into the water that I am going to drink (this is much better than counting drops like some suggest). Then I drink it down. I try to do this in the morning as MB activates NRF2 and NRF2 boosts the circadian rhythm.

I plan on sticking with MB for quite a while. I don't know if it is possible to stop the damage going on, and I am even less sure if it is possible to repair damage. But I am pretty sure that if either is possible, it will take a while (I have a High School degree).

Here are pictures of my jar of Methylene Blue and my suction thingy (you can get a suction thing at the drug store that will measure ml also). I keep this stuff in a dark closet:

Here is a link to our last HU post on MB: healthunlocked.com/cure-par...

[park_bear]

Is there a particular reason to attribute these improvements to the methylene blue or is it just one of the many in the stack?

---

A person can also actually measure milliliter quantities using a hypodermic syringe body with a blunt tip or no tip attached.

[Bolt_Upright]

I wish I could have bolded "Is MB helping? I don't know. I take a lot of things." It is odd that you can format replies but not the original post.

So... no, I don't know what is helping. And it is subjective. I just know that I will stick with it because: A) If it helps, I figure it will take awhile, and B) 5 Grams is a lot of MB. At my rate of consumption I have 500 days worth

[Despe in reply to Bolt_Upright]

Hubby had to stop it. Didn't see any difference plus the toilette bowl turned blue. However, what has made a tremendous difference is umPEA with Lut. He took his 1/2 t of Sinemet with two MP caps at 2:00 pm with umPEA and Lut. He didn't need any levodopa until almost 8:00 pm! Talkative and his gait was a lot better. We are sticking with this combination, following the trial.

[akgirlsrock in reply to Despe]

Hello, what is umpea/Lut? Thank you, Maria

[Despe in reply to akgirlsrock]

pubmed.ncbi.nlm.nih.gov/262...

There was a lot of discussion about the supplement. I personally purchase umPEA naturitas.us/p/supplements/... with Luti MAX amazon.com/Natural-Luteolin...

[glenandgerry in reply to Despe]

I've recently been giving my HWP umPEA powder (same brand as Bolt_upright uses) but I didn't know about adding luteolin.Despe, the links to the products you mentioned aren't working for me. I think this may be because I'm in the UK. I shall have to look further at Luteolin (I may message you privately about that), but thanks for the product suggestions. Good to know that umPEA seems to be working for your husband 😊 How long before you noticed?

[Bolt_Upright in reply to glenandgerry]

There was an ")" in the link messing it up. Here is a good link to the PEA supplement: naturitas.us/p/supplements/...

[glenandgerry in reply to Bolt_Upright]

Thanks Bolt. Is this essentially the same as the powder you take and which I ordered from the U.S?

[Bolt_Upright in reply to glenandgerry]

Yes, I think it is the same. It is ultra micronized PEA. Theirs is in a pill, ours we have to measure.

[Despe in reply to Bolt_Upright]

Thanks, Bolt.

[Despe in reply to glenandgerry]

Hi, Glenandgerry!

About 2 weeks into the umPEA and Lut, I noticed improvements. What I am looking forward to seeing is possible correction of his posture. He leans forward a lot and when we go out for a walk, he speeds a lot and can't stop. I have him rest his arm on my shoulder to slow him down. Posture is EVERYTHING!

naturitas.co.uk/p/supplemen...

NATURITAS is also in UK naturitas.co.uk/p/supplemen...

amazon.com/Natural-Luteolin...

[Zardoz in reply to Despe]

What is umPEA & Lut?

[Despe in reply to Zardoz]

Please see my reply to Maria.

[JayPwP in reply to Despe]

What is the Umpea and lut dosage he takes? And the time?

Will this work: amazon.com/dp/B08C8JTD8Z?gc...

[Despe in reply to JayPwP]

I believe it will. He takes umPEA with Lut twice a day with his C/L.

[JayPwP in reply to Despe]

Thanks

[dvoranel]

Hi Bolt. Someone recently posted about the contraindication of taking MB with levodopa. I’m unable to locate that post and wonder if you may be able to find it. I am very interested in trying MB as you are doing but am also taking levodopa so I’m concerned. Thank you!

[chartist in reply to dvoranel]

dvoranel,

This may be the warning you are referring to regarding the use of levodopa and methylene blue :

webmd.com/drugs/2/drug-1317...

Here is a relevant quote from the article :

>>> ' Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process levodopa properly.

What might happen:

You may experience an increase in the toxic effects of levodopa including extremely high blood pressure, blurred vision, and muscle twitching. ' <<<

::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

Art

[dvoranel in reply to chartist]

Thank you Art!

[Bolt_Upright in reply to dvoranel]

Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

[Bolt_Upright in reply to dvoranel]

I got so busy posting warnings I neglected to thank you Deborah for raising the alarm. Thank you!

It would be nice to find an expert that could weigh in on how much oral MB would put a person in LC in the danger zone. I know Dr Ken Gillman is an expert and for SSRIs he seemed to indicate that 200 mg of oral MB could put you in the danger zone. He did not say less than 200 mg is safe with SSRIs and he did not mention LC.

Here is a paper from Dr. Gillman:Methylene Blue & Serotonin Toxicity Syndrome psychotropical.com/methylen...

Here is another great paper on it: Demystifying serotonin syndrome (or serotonin toxicity) 2018 cfp.ca/content/cfp/64/10/72...

[ForViolet]

Thank you for the MB update. Please continue to check in w your progress. I noted you take a lot of things btw.

[Bolt_Upright]

Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

[dvoranel]

Thank you so very much Bolt. That is really important info for those of us on levodopa

[Hikoi]

Welcome gymbag I am waiting for your witty humour to surface

[JayPwP]

Apologies for the questions below. I am not on any Parkinson medication.1. How did you arrive at 10mg dosage? Is it once a day?

2. Do you take MB on empty stomach or with breakfast?

3. Typical dilution for MB is 0.1%, that means 1gm diluted with 1 litre of water, then why is your dilution so dense?

[Bolt_Upright in reply to JayPwP]

1: I chose my 10 mg dose based on: A) Dr Mercola says he takes 20 mg. B) I am on Prozac so I am trying to keep my dose low. C) In an AD trial in 2016 they gave the control group 8 mg of MB just to turn their pee blue so they would not know they were the control. They figured 8 mg would not have any effect. Turns out the 8 mg dose worked just as well as the 150 mg dose (and with no side effects): healthunlocked.com/cure-par...

2: I take MB on an empty stomach in the morning. MB is a NRF2 activator. NRF2 boost the circadian rhythm. Circadian rhythm peaks at about 1-2 PM. I think boosting the circadian rhythm should be done on the upstroke.

3: I have noticed they sell MB at .1 percent. I just know I want 10 mg. 1 gram into 100 ml makes 10 mg per ml. Simple and easy. I can just draw 1 ml instead of drawing 10 ml if I was using a liter of water. I squirt my 1 ml into about 4 ounces of water and drink it that way.

Please keep in touch and let us know if it helps.

[JayPwP in reply to Bolt_Upright]

Have ordered the MB. Will let you know

[JayPwP in reply to Bolt_Upright]

I take 1g b1 hcl along with a methylated b complex in the morning, then 20mg melatonin at noon, then 300mg niacin NA post lunch, then 500mg curcumin with 30mg melatonin before bed with 1tbsp mct & 1tbsp coconut oil.

Confused about when and how to include MB in this mess?

Any help appreciated

[Bolt_Upright in reply to JayPwP]

Anything that activates NRF2 I try to get in the morning.

I don't see broccoli sprouts on your list

[JayPwP in reply to Bolt_Upright]

I don't get the sprouts here

[Bolt_Upright in reply to JayPwP]

You can't get sprouts? I sprout my own. It is easy and fun. I sprout broccoli and daikon radish and have about 40 grams of broccoli sprouts and 20 grams of radish sprouts a day.

[JayPwP in reply to Bolt_Upright]

Must try sprouting

[Manypony in reply to Bolt_Upright]

Just once per day?

[Bolt_Upright in reply to Manypony]

Yes. In the morning. Sulforaphane activates NRF2, NRF2 boosts the circadian rhythm, circadian rhythm peaks around 1 or 2 PM. I think we should time our boosting of the circadian rhythm so we are doing it on the upstroke.

[Zardoz]

How unfortunate that we cannot take MB if we're taking levodopa. So many of us PWP's, myself included, are desperate for anything to fix the fatigue problem.

For what it's worth, octacosanol came to my attention as something "used to improve exercise performance including strength, stamina, and reaction time." It was said to be of benefit in Parkinson's Disease, but carries the warning not to be mixed with levodopa.

rxlist.com/octacosanol/supp...

[Gioc]

IMHO niacin could play an important role.

[Bolt_Upright in reply to Gioc]

I take 150 mg of Niacin twice a day. What are you at (if I may ask)?

[Gioc in reply to Bolt_Upright]

The gains you describe are similar to mine when I take niacin. I take a lot more but occasionally every two to three months for 20 days with all the other vitamins and minerals. My variation of an anti-aging protocol (d.a.n.i.) of an Italian doctor. All very experimental. I don't recommend it , much better that you do.🍦😁

+* 6/11/2022 Service communication: I sent you a private message but it would seem that this line is not working.👋

[Ghmac]

Bolt - can you give me the original link you posted on MB? I have looked for it an it didn't come up.

[Bolt_Upright in reply to Ghmac]

Be sure to read the cautions. healthunlocked.com/cure-par...

[Manypony]

My source is liquid drops. 1 drop is 1.5 mg. So 10 drops 15 mg. It’s suggested to work up to 15 mg twice a day. I’m small! I’m peeing blue/ green so backing off a little. Open to suggestions! Especially when to take. I want it first thing then again later in the day. I too take a lot of remedies including Traditional Chinese Herb tea twice a day I have to fast 1 hr before and after

[Bolt_Upright in reply to Manypony]

What brand did you get? Link?

[Manypony in reply to Bolt_Upright]

This says 3%

Label

[Manypony]

It’s Liposomal Blu, under non clinical research at this time

[Manypony in reply to Manypony]

It’s 3%

[Manypony]

I’m thinking 10-15 mg only in the morning

[JayPwP]

Any update Bolt?

[Bolt_Upright in reply to JayPwP]

As of 6/21 I am taking a break from MB. I started at 5 mg 4/29, went to 10 mg 5/8, and my REM Sleep Behavior Disorder has been way worse as of 6/16.

I had also started Betaine 6/12 so I stopped that also on 6/20.

I don't know if MB is the issue. I was a bit hesitant to start MB only because I was doing so well before I started that I thought maybe I should not rock the boat. Maybe I should have listened to my gut.

[JayPwP in reply to Bolt_Upright]

Thanks. So what dosage do you suggest I should start with?

[Bolt_Upright in reply to JayPwP]

First, make sure you read this:

Edit 3 June 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

I started with 5 mg just to see what might happen (I am on Prozac) then moved to 10 mg. I chose my 10 mg dose based on: A) Dr Mercola says he takes 20 mg. B) I am on Prozac so I am trying to keep my dose low. C) In an AD trial in 2016 they gave the control group 8 mg of MB just to turn their pee blue so they would not know they were the control. They figured 8 mg would not have any effect. Turns out the 8 mg dose worked just as well as the 150 mg dose (and with no side effects): healthunlocked.com/cure-par...

[JayPwP in reply to Bolt_Upright]

I am not on any PD meds. But I am concerned about methylene blue safety profile, and what should be my starting dose, and how far can I increase it up to?

[Somic67 in reply to JayPwP]

Well done.Keep on not taking any levodopa drug especially at std medicine dose.

[JayPwP in reply to Somic67]

I don't take any PD meds because I am not responsive to them. Have tried amantidine, rasagiline, C-L combos including entacapone

[Somic67 in reply to JayPwP]

Ok. I’m sorry. I didn’t know that. How did you manage this? Is there anything else that works for you?

Have you tried high doses of butyrate, with/w.out alfa-lacto-albumine or vit C od mannitol?

[Bolt_Upright in reply to JayPwP]

If I was still taking MB, and not taking Prozac, I would shoot for 20 mg a day. I think that is what Dr Mercola suggests. That is a low dose.

[JayPwP in reply to Bolt_Upright]

Thanks, I will start by 5mg, and titrate up to 20mg slowly

[MBAnderson in reply to JayPwP]

If you are taking it because Mercola says he does, that would be the worst reason possible. He says he's taking it because he sells it. He says that about everything he sells.

Check him out. More serious negative stuff about him than any other health guru on the internet.

He promotes himself as a medical doctor which he is not.

"... Melatonin Sleep Support Spray ($21.94 for three 0.85-ounce bottles) to Organic Sea Buckthorn Anti-Aging Serum ($22 for one ounce)—as about trying to inform.

"Your tampon “may be a ticking time bomb,” —but you can buy his “worry-free” organic cotton tampons for the discounted price of $7.99 for 16.

Steven Salzberg, a prominent biologist, professor, and researcher at the Johns Hopkins University School of Medicine, calls Mercola “the 21st-century equivalent of a snake-oil salesman.”

"...the FDA demanded that Mercola cease touting a thermographic screening he offers—which uses a special camera to take digital images of skin temperatures—as a better and safer breast cancer diagnostic tool than mammograms.

"... the Better Business Bureau has tagged Mercola.com with an F rating, its lowest, due in part to customer complaints that the company doesn’t honor its 100 percent money-back guarantee. "

"He even advocates something considered outright heresy to most skin doctors: the use of tanning beds. Specifically, he recommends the Mercola Vitality Home Tanning Bed—on sale at his site for $2,997 (“Incredible Deal!”)"

and on and on

for $60/year you can buy his rants

articles.mercola.com/sites/...

[JayPwP in reply to MBAnderson]

Thanks Marc.

I am not taking it because of Mercola.

I want to try it because of the mitochondrial benefits it offers.

[MBAnderson in reply to Bolt_Upright]

Mercola, no wonder.

Anything that turns one's pee blue can't be good.

Essentially, it can't be taken with any common drug. It is contraindicated for 135 drugs (at a severe reaction level) meaning it probably should be considered a dangerous drug.

"... may precipitate serious serotonin toxicity, serotonin syndrome, if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitor..."

Why be dinking around with it since it does nothing special?

[Bolt_Upright in reply to MBAnderson]

I have to belatedly agree Marc. There are things that MB does, but reviewing it all, it all seems fairly speculative.

This is a good thread on MB:healthunlocked.com/cure-par...

On the other hand, they are/were going to trial MB for AD: clinicaltrials.gov/ct2/show...

And then there is this Francisco Gonzalez-Lima guy: peterattiamd.com/franciscog... This is a podcast. He seems to think MB might help with vascular issues in the brain.

All pretty speculative.

[Gigi216 in reply to Bolt_Upright]

Yes methylene blue did not agree with me at all, I wanted all the wonderful things claimed but didn’t pan out

[noodle59]

The SSRI are probably not helping you.

[Getz]

Mate, I would like to thank you for putting me on to this. I have just started my 2nd vial and am feeling noticeably better. Nearly no PD indications other than memory.

[Bolt_Upright in reply to Getz]

That is good to know. You are welcome. I am back taking MB. I have a 1 gram to 100 ml solution in a CBD oil squirt bottle and have 10 squirts in the morning and 10 squirts at night. I an following the advice of this person who suggested to just take enough that your pee changes color.

So how were your symptoms before you started MB?

[Getz in reply to Bolt_Upright]

I'd been doing red light therapy, taking numerous supplements, and fast walking for an hour 3x weekly and had improved dramatically. Since MB the slight shakes have stopped and I can write legibly again. I'm still doing everything I previously did but I now feel normal.

[Bolt_Upright in reply to Getz]

That is great!

[Getz in reply to Bolt_Upright]

I forgot to mention that I have been taking Mannitol as it kills off alpha synuclein (which misfolds neurons) and MB actually kills off "tau" another neuron destroyer.

This combination may be a major benefit in PD treatment.

[Bolt_Upright in reply to Getz]

Hmm. I have Mannitol on my island of misfit supplements. Maybe I should consider bringing it back.

[Getz in reply to Bolt_Upright]

Its worth trying for a few months. I'm not sure that adding MB to my protocol is the main reason for improvement but it has been the only change and I am back to normal (I believe).

[Bolt_Upright in reply to Getz]

Are you on PD medications (if I may ask)?

[Getz in reply to Bolt_Upright]

Nothing from specialist or GP. Neither of them were aware that alpha synuclein climbed the vagus nerve and crossed the Blood Brain Barrier to misfold neurons though there is plenty of scientific research toprove this.

Lunch smoothie includes Budwig flaxseed oil and cottage cheese (prostate cancer) then mercura pruriens, mannitol, Lion's mane, beetroot, blueberries, cinnamon, Pomegranate juice to make it fluid. I did include L-Serine but am having trouble finding a reliable source (will never try India again). B1,3 &12, CoQ10. I occasionally add Brahmi and Amla to the smoothie.

Have been using the red light helmet from the Men's Shed in Tasmania as well as a PEMF mat, and John Pepper's fast walk 3x weekly.

Healthy diet of course.

[chartist in reply to Getz]

Getz,

This may be of interest to you :

ncbi.nlm.nih.gov/pmc/articl...

Art

[Getz in reply to chartist]

Thanks Art. By the way you are a hero of mine as your articles are in basic English I can understand. Thank God for the conclusion of this one which is written in English. The rest may as well be ..... . Your article in Earth Clinic on MB was great.

With my prostate cancer I have been taking DCA, Ivermectin, Low Dose Naltrexone, and Gumby Gumby and I'm hoping that when I go in for my biopsy next month I will be clear. I have had a lesion on my prostate that over 3 years has gone from 10mm to 12 mm to 11 mm and the specialist said it was 80% cancerous. I was quite happy to have it treated but as a public patient in rural Queensland, Australia, they won't do a thing unless it is 100% diagnosed by biopsy. The prostate is double its correct size and makes peeing difficult with sleep interruption but I am taking grape seed extract and this reduces peeing to 3-4 times nightly rather than 5-6. I have also started taking 2mg melatonin to help me sleep.

If you have any further advice I would really appreciate it.

[chartist in reply to Getz]

Getz,

It sounds like you have it well covered! The DCA is fairly potent and any potential peripheral neuropathy is usually reversible with proper supplementation once the treatment is done.

For the enlarged prostate, pumpkin seed oil(PSO) may help and seems worth a try in order to get better sleep. The usual beta sitosterol and saw palmetto may be additive to the PSO

Art

[Getz in reply to chartist]

Thanks. I simply ran out of beta sitosterol and saw palmetto and didn't buy any more as I take so many pills. Shall get some today.

[Nomadish]

Hi Bolt, I just ordered some Methylene Blue and am researching the contraindication for SSRI's, particularly Levodopa. I see that you take MB and SSRI's apparently without a hypertensive crisis. It seems that carbidopa has been reported to prevent or blunt the hypertensive response. Are you able to share any insights or research with me?

Thanks!