Interesting Methylene Blue Dosing Story

[Bolt_Upright]

Edit: March 24, 2024

According to this paper, TauRx Parses Subgroups to Make the Case for Methylene Blue Derivative, Again alzforum.org/news/conferenc... some researchers are not really buying the effectiveness of LMTM (a stable reduced form of MB) for AD. Apparently this drug company goes through a lot of statistical and analytical gymnastics to find the silver lining in their trial results.

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So... they did a trial with Methylene Blue for AD back in 2014 core.ac.uk/reader/29151100 and determined the minimum effective dose was 138 mg (it is not). They also found it was hard to stomach 138 mg, but if you took it with food then you absorbed less.

So... they did another trial in 2016 ncbi.nlm.nih.gov/pmc/articl... with LMTM (a stable reduced form of MB) for AD. This time they gave one group 150 mg a day, another group 250 mg a day, and they gave the control arm 8 mg a day (4 mg twice a day) JUST TO TURN THEIR PEE BLUE SO THEY WOULD NOT KNOW THEY WERE THE CONTROL ARM. They figured 8 mg a day would not skew anything as the 2014 study had already shown that 69 mg was much less effective than 138 mg.

Here is the interesting part: In the 2016 study, the control group taking 8 mg a day did just as well as the 150 mg and 250 mg a day groups! Except the 150 and 250 mg groups had a bunch of gastrointestinal issues ncbi.nlm.nih.gov/pmc/articl...

One more thing about the 2016 study: LMTM was ineffective at any dose if the patient was on other AD drugs. It only worked as a monotherapy.

There is a whole lot more information in this 2018 paper: ncbi.nlm.nih.gov/pmc/articl...

Here is one more amazing story about LMTM: content.iospress.com/articl...

[SilentEchoes]

I don't know if I said it outloud before - I believe my ALS was caused by the agrochemicals forming cyanogen's in the tank mix -- cyanide poisoning. This happened in 2014. Methylene Blue is the antidote along with B12. It helps with depression too. Didn't know if it was treatable after so long (almost 8 years). Maybe it is reversible?!

Methylene blue

[Bolt_Upright in reply to SilentEchoes]

I hope and pray ALS is reversible. I did a search on MB and ALS and did not find much. It worked for worms but not for mice. But we are not mice, and many times things work for mice but not for people.

[SilentEchoes in reply to Bolt_Upright]

There are now about 100 documented cases of recovery. Some might say that it wasn't truly ALS.

There are really only a few criteria, upper and lower motor neuron signs ✔️ muscle atrophy ✔️ and progression ✔️ it doesn't matter if progression is fast or slow and it doesn't matter if you know causation, those are not diagnostic criteria.

So why couldn't someone recover from PD?

I'm working on a post - stay tuned 🙂

SE

[Psans7975 in reply to Bolt_Upright]

What have you tried so far for your ALS ?

Low Dose naltrexone?

LLLT/red light therapy?

Ketogenic diet

The Wahl's protocol?

B1/Thiamine megadose ?

Transdermal magnesium ?

[Bolt_Upright in reply to Psans7975]

You were replying to SilentEchoes , right?

[Despe in reply to SilentEchoes]

I sure hope so, SE! I pray for a disease modifying medication or supplement.

[Despe in reply to SilentEchoes]

This is what I ordered. Company will close in a few months though. . .

[Bolt_Upright in reply to Despe]

You ordered that Science brand?

I ordered the powder from Amazon. 5 grams for $70. I should be able to make 500 ml of 1% solution. Fingers crossed.

[SilentEchoes in reply to Bolt_Upright]

What dosage are you doing?

[Bolt_Upright in reply to SilentEchoes]

I have not started yet. I need to start weening off my Prozac (even though I am pretty sure it is safe to take at the same time). When I start, I plan on starting at 5 or 10 mg a day. It seems that they have not identified a minimal effective dose really.

One other thing making me hesitate is that I am starting to feel better. Better mood. Shoulder is somewhat better. I am starting to wonder if the combination of things I am doing are helping. I am nearing a month into PEA and close to 8 weeks of Honokiol/Magnolol. I am trying to be present and aware at this time.

But using MB is still my plan. Everything I have read about it looks promising.

[Despe in reply to Bolt_Upright]

Yes, that is what I ordered. Haven't received it yet.

[SilentEchoes in reply to Despe]

Me too 🙂

[Manypony]

I will post my brand dosage and outcomes soon

[Bolt_Upright]

Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...

"methylene blue oral and levodopa oral

methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."

[Getz]

I have only just come across MB and now your post. I cannot understand the scientific language involved so could you give me a simplified run-down on this please. I do have the early stages of PD and have totally modified my diet and exercise program.

What is your final view on MB? Is it worthwhile taking and if so, what dose.

[Bolt_Upright in reply to Getz]

Here is a good video. I follow this dosing plan (I have enough to turn my pee green):

youtu.be/dYlTsQNP5iM(Not working as expected?)

[Bolt_Upright in reply to Bolt_Upright]

youtube.com/watch?v=Irh5Fgi...(Not working as expected?)

[Bolt_Upright in reply to Bolt_Upright]

youtu.be/LwXszYVNwa4(Not working as expected?)

[Getz in reply to Bolt_Upright]

Thanks. I bought from CTZL and got a $10 discount using the Jane10 code. Just waiting now until it arrives. Really looking forward to trying it as the benefits seem soooo broad. Great for PD as well as cancer. I really appreciate your posts.

[Getz]

My methylene blue should arrive tomorrow. Jane's video shows 100ml and she squirts some of that into her mouth but the amount is not specified. With your reading of the dosage how much daily would you suggest or how long should the 100ml last.

[Bolt_Upright in reply to Getz]

She does not specify because she is using an unusual strategy. Through trial and error she has enough to make her pee turn green.

I was taking 10 milligrams a day last year. Might have got up to 15 milligrams.

Now I use Jane's method and have figured out that about 10 squirts in the AM and 7 more squirts in the PM have my pee greenish most of the time.

[parkie13 in reply to Bolt_Upright]

Is it working?

[Bolt_Upright in reply to parkie13]

It is hard to say what, if anything is working. I am somewhat better than I was 2 years ago. I have not been diagnosed with PD. I have RBD and a sore left shoulder and are and leg and random movements and face dandruff and lightness of head when standing and balance issues. Over the last 2 years all of these things have improved somewhat. Maybe.

[Getz in reply to Bolt_Upright]

Have been on MB for nearly 2 weeks now. The spray method was too strong for me and 2 doses a day left me sleepless at night. I now take 2.5 to 3ml first up in the morning using the pipette to squirt it to the back of my throat. This is enough to make my pee slightly green/blue. I have no idea if it is working but I'm sticking with it as all the reports sound so good. Also taking it for prostate cancer and I go in for a biopsy in a bit over a month so maybe that will be a positive indication.

Thanks so much for your post. It has certainly given me hope.

[parkie13]

Hi Bolt, This is kind of strange. I have had parkinson's for over 10 years now. The only thing that has ever helped me is thiamin HCL, I take 500 mg per day. I also give myself a holiday from it since it gives me high blood pressure. What I found strange is that my symptoms in the beginning were horrible since than they have gotten a lot better. Since it's over 10 years I am getting worse again. In the beginning I have lost my smell, I have lost my taste, however quite a few years ago it has come back, maybe not to the degree as before I got Parkinson's but yes I can smell and I can taste. What I have noticed now I have off periods and my Sinemet is not working as well. I'm up to eight pills 100/25 . So, things do change. Mary

[Bolt_Upright in reply to parkie13]

Thanks Mary. I hope we find something that reverses this for you and everybody.

[Boscoejean in reply to parkie13]

it is puzzling how something has seemed to improve my husband's sense of smell at times but not sure what it is- he has not had much of a sense of smell for about 9 years but recently there have been a couple days when he says he can smell some strong smells. He is taking thiamine so maybe that is what helps