Methylene Blue: Biohacker's Delight, or Playing With Fire? Chris Masterjohn, PhD is Not Too Keen on MB :( Insanely Detailed Video!

[Bolt_Upright]

I take a small amount of MB twice a day. As close as I can tell from this insanely detailed video, this PhD probably thinks I am making a mistake

Methylene Blue: Biohacker's Delight, or Playing With Fire: youtube.com/watch?v=XhgGGbd...(Not working as expected?)

This is a 51-page guide in which you will learn the following:

00:00:00 The Origin of Methylene Blue

00:08:54 The Entry of Methylene Blue Into Medicine

00:13:59 From Malaria to Many Uses in Medicine

00:26:20 How Methylene Blue Works

A Redox-Reactive Dye

The Blue Bottle Experiment

Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites

Methylene Blue Can Oxidize and Reduce Many Targets

Methylene Blue Can Rewire the Mitochondrial Respiratory Chain

Rewiring the Respiratory Chain Does Not Make It Better

Methylene Blue Increases Hydrogen Peroxide

Hydrogen Peroxide Kills Microbes, Has Hormetic Benefits, But Is Still Ultimately Toxic

Methylene Blue Causes Redox Cycling of Hemoglobin

Methylene Blue Is a Strong Monoamine Oxidase A Inhibitor

Methylene Blue Inhibits Nitric Oxide Synthase

Mechanistic Conclusions

02:09:14 Is Methylene Blue Fundamentally Hormetic?

02:15:06 Methylene Blue Fails in Alzheimer’s, and Causes a Worrisome Side Effect

02:23:57 Whether Methylene Blue Helps Or Hurts Depends on Whether You Need It

02:30:16 Natural Alternatives for Hormesis and Rewiring the Respiratory Chain

02:33:27 Who Should Use Methylene Blue?

[SilentEchoes]

Francisco Gonzalez-Lima, PhD: Professor at UTexas, his street cred includes toxicology and he is an expert on Methylene Blue. The video is long, 1:44, but well worth your time. Before you make a decision you need to consider all points of view. I understand the nature of the chemicals I was poisoned with. For me MB is a no brainer.

dellmed.utexas.edu/director...

deeprootsathome.com/methyle...

SE

[MBAnderson in reply to SilentEchoes]

Hydroxychloroquine and Mercola in the same sentence is enough to keep me away.

[SilentEchoes in reply to MBAnderson]

If you leave your bias against Mercola out of the decision making tree and listen to Gonzalas-Lima you would know the history of MB and HCL. I'm not going to debate someone who refuses to inform themselves. It's a waste of my time and energy and as you know, those are both in short supply. I'm very sick right now dealing with chronic pyelonephritis and kidney abscess that lead to sepsis. I'm using MB in addition to Infectious Diseases protocol 2x antibiotics + antifungal for a medical mistake. I'm following Dr. Gonzalez - Lima's protocol of 10mg 4x day. It has zero to do with Mercola conducting the interview. You should be able to separate the two.

Be well,

SE

[MBAnderson in reply to SilentEchoes]

I sincerely hope it works for you.

[MBAnderson]

2 hours and 38 minutes! Like watching Titanic, except with no entertaining segments.

[SilentEchoes in reply to MBAnderson]

My time is valuable too, even my husband found time to sit through it. We make a lot of health decisions together because he is my caregiver and needs to understand the "why."

[Despe in reply to SilentEchoes]

articles.mercola.com/sites/...

Hope you win your war, SE! You are a fighter! Above will be off line soon. . .but you probably have received it, too.

[SilentEchoes in reply to Despe]

Thanks Despe, I saved the article. The sky is falling.From one warrior to another, Be well.

SE

[Despe in reply to SilentEchoes]

As usual, we are on the same page. 😉

[Bolt_Upright in reply to Despe]

Thanks! I downloaded this too.

[Despe in reply to Bolt_Upright]

Any time, Bolt! I have download lots of his posts.

[MBAnderson]

Dave, I've listened to his explanation thrice now as to who should take it and don't understand why you are taking it. i.e., what malady are you treating?

[MBAnderson in reply to MBAnderson]

PS. "...this PhD probably thinks I am making a mistake."

I'm concerned you may be right about this and we'd hate to lose you from the Zoom meetings

[MBAnderson in reply to MBAnderson]

PSS He calls Berberine a complex1 toxin

[chartist in reply to MBAnderson]

Does he include a study link to confirm that and at what dose in human or animals? That seems akin to calling it a pesticide.

Art

[MBAnderson in reply to chartist]

I didn't see one, but his comment re Berberine is at 2:31:26

He said it was a "poison," not a toxin??

[chartist in reply to MBAnderson]

Marc,

I just listened to what he said about berberine and he did not qualify it in any way, he just threw it out there and I can only guess that he means at a higher dose than what berberine is normally used at (1500 mg/day). Other than that, I disagree as do hundreds of berberine studies .

The LD50 for mice is 1600 mg/kg/bw. If I were to convert that to a human dose for me, it would be over 10,000 mg or greater than 6 times the regular dose. It would be nice if he said what he was basing that on, rather than just saying it. By him saying that without qualification, it will automatically lead some viewers to think they should not take berberine and that is not only wrong, it is bad science.

Imo, if you are going to make a broad sweeping claim in a public forum, as he did, without offering the supporting evidence, you shouldn't say it at all .

You'll have to excuse me as I have to go take my berberine now.

Art

[SilentEchoes in reply to MBAnderson]

Same difference

[Gioc in reply to MBAnderson]

Berberine is a slightly phytotoxic quaternary ammonium salt, but it is an excellent anti-green mold and topical antibacterial, IMO its place is on the detergent shelf where you can also buy other products based on synthetic quaternary ammonium salts.😁

healthunlocked.com/cure-par...

[Bolt_Upright in reply to MBAnderson]

Sorry for the delay Marc. I will try and figure out why it is I take MB and update this thread.

[MBAnderson in reply to Bolt_Upright]

you'll like this one, especially because he is apparently part of the FLCCC Alliance, a group of contrarians & anti vaxxers

youtu.be/BmSUlYePGtE?si=SOZ...(Not working as expected?)

[chartist in reply to MBAnderson]

Dr. Been always brings the receipts, real details and requisite drawings that he is well known for, unlike others who could learn a lot from him!

Art

[MBAnderson in reply to chartist]

Yeah, I think it a good video

[chartist in reply to MBAnderson]

Marc,

Since Dr. Been was concentrating his discussion on methylene blue and RLT effects on mitochondria, he did not mention a more important aspect of mitochondria, what keeps mitochondria healthy and maintains the mitochondrial respiratory transport chain without methylene blue and RLT? The answer is melatonin which is made in the mitochondria and scavenges both ROS and RNS while returning the the mitochondrial respiratory transport chain to homeostasis, increases ATP production and generally maintains proper mitochondrial function while protecting the cell where the mitochondria are located.

The problems begin with the age related decline of melatonin which starts to become noticeable around the age of 35 years. Mitochondria are thought to produce the most melatonin in the body, but mitochondria are also thought to be the largest producer of reactive oxygen species in the body as part of their normal function. Melatonin seems to be quite adept at maintaining mitochondrial homeostasis until around the mid 30's when the age related decline of melatonin is significant. Methylene blue is not native to the body. Red light therapy (RLT) is known to increase mitochondrial production of melatonin as well as improved mitochondrial function.

All of the things that he said low dose methylene blue does to the mitochondria that are beneficial, melatonin does most if not all of, but melatonin is native to humans, animals and plant life. Mitochondria and cells have melatonin receptors for a reason and melatonin is produced directly in the mitochondria while melatonin plies its beneficial effects via these receptors which are located throughout the body.

It makes sense to me to try and compensate for the age related decline of melatonin via melatonin supplementation, earlier morning and later afternoon sun exposure ( a natural form of red light therapy) and eating melatonin rich foods. The older we get, the less time we spend outdoors in the majority of people and that results in a decline in melatonin production as well as insufficient vitamin D levels. Yes, vitamin D is another contributor to mitochondrial health through various mechanisms of action. Even though mitochondria produce melatonin, mitochondria also have the ability to use melatonin from outside the mitochondria if needed.

ncbi.nlm.nih.gov/pmc/articl....

A relevant quote :

' The absence of melatonin synthesis in the mitochondria significantly alters their physiology due to its multitude of functions in these organelles (Figure 3) [105,146]. One of the major roles of melatonin in healthy cells is to maintain mitochondrial redox hemostasis, in part, by scavenging ROS and RNS when the cells are challenged with an oxidant [103,104]. The presence of melatonin would be even more important under pathological conditions [177], especially in cells manifesting Warburg-type metabolism. Excess O2.− would be formed in these cells due to the less efficient ETC leaking additional electrons. O2.− is the first in a chain of partially reduced oxygen and nitrogen-based derivatives that inflict damage at the mitochondrial level (Figure 4). '

I see the value of methylene blue, but I see at least as good a value or more from melatonin which is a major contributing factor to maintaining mitochondrial homeostasis and is completely native to the human body and when gotten from the sun, includes the mitochondria useful, vitamin D !

Art

[MBAnderson in reply to chartist]

You have sold me on the wisdom Melatonin, hence, I take 60 - 70 mg/day.

What is your opinion of a pwp taking MB?

One thing that legitimately scares me about MB is Mercola sang its praises in his typical, grossly exaggerated format

[chartist in reply to MBAnderson]

I think for people who do not want to take oral melatonin and do not want to get it from the sun, MB is an option worth considering as it is also a promoter of the Nrf2/ARE pathway like melatonin which results in increased production of some of the bodies own potent antioxidants, but vitamin D is still needed either way to add to the pro-mitochondrial effects of MB or melatonin.

The bottom line is that the mitochondria are damaged in PD and this very likely leads to disease progression to some degree, so returning mitochondrial function to homeostasis through a safe method is an important step in minimizing disease progression and improving body function.

Art

[MBAnderson in reply to chartist]

It feels counter intuitive to ingest something that is blue and used by some to clean their fish tank of fungus.

[chartist in reply to MBAnderson]

Well, I can't say much on that topic as I take Borax laundry booster every weekday to keep my severe psoriatic arthritis(PA) in remission for about 15 years now! From unbearable pain from the PA everyday, to no pain everyday from Borax. Borax is one thing I have taken that clearly makes a very significant and obvious difference for me. Not everyone can tolerate it, but for the people it works for their arthritis, it is life changing. It also helps to prevent osteopenia and osteoporosis.

Google Borax and arthritis and you will quickly realize that I am not the only kook using borax in this way. I wrote about it here years ago, when I was known as "easily" on this forum :

healthunlocked.com/cure-par...

Art

[MBAnderson in reply to chartist]

No thanks on that, too.

[chartist in reply to MBAnderson]

Marc,

It has limited science to support its use for this purpose and it has a very good safety profile that is similar to table salt, but will remain basically unknown as a remedy for arthritis. Borax costs less than a couple of bucks a year to use whereas the biologics for arthritis can cost over $500,000 per year and the average cost is $10,000 to $30,000 per year and come with the potential for serious side effects. Here is info on biologic costs for arthritis.

verywellhealth.com/cost-of-....

Boron works also, but costs a little more than borax and some people feel more comfortable taking a boron supplement instead of a laundry booster.

Here is a link to a study that used borax (sodium tetraborate) and calcium fructoborate, which is borax that is derived from plants, in people with arthritis to good effect :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant study quote :

' After 60 days, both types of boron significantly improve the clinical scores, in association with significant decrease in the serum levels of ESR, hsCRP, IL-1α, IL-6, and TNF-α with remarkable superiority for calcium fructoborate (CFB) over sodium tetraborate (NTB), compared to baseline and placebo-treated group. '

This study puts borax into microspheres as a time release device for borax :

pubmed.ncbi.nlm.nih.gov/229...

Here is a relevant quote :

' The novel microsphere/thermoresponsive hydrogel combination system could be a promising treatment option for OA and RA. In conclusion, the system appears to be generally biocompatible with synovium and could control the drug release for several days; hence it might be suitable for the development of treatment strategies for rheumatic diseases. '

ncbi.nlm.nih.gov/pmc/articl...

A relevant study quote :

' A significant favorable response to a 6 mg boron/day supplement was obtained; 50% of subjects receiving the supplement improved compared to only 10% receiving the placebo. The preceding data indicate that boron is an essential nutrient for healthy bones and joints, and that further research into the use of boron for the treatment or prevention of arthritis is warranted. '

In over 15 years of use, I have remained in remission and pain free with no apparent side effects.

Art

[MBAnderson in reply to chartist]

Only you could have figured this out.

[chartist in reply to MBAnderson]

I can't claim that, but the information has been there for around 50 years, but majorly ignored. How do you make money on something that costs less than two dollars a year. Even the plant based version, calcium fructoborate, as well as boron itself, while more expensive than borax, are still way less expensive than the arthritis biologics.

I think it was Dr. Rex Newnham who discovered using boron and borax for various forms of arthritis in the 70's, but it has remained relatively ignored since then. He found that areas of the world that had low soil boron content have very significantly higher rates of arthritis while areas of the world with high soil boron content had significantly lower rates of arthritis.

I can only confirm that it has worked like a miracle for me for over 15 years.

Art

[Gioc in reply to chartist]

Il Boron competes with calcium in the chemical reactions of cellular life and is often lacking in modern nutrition. This is mainly due to intensive agriculture which demineralises the soil and does not replenish the so-called microelements, such as boron.

Boron deficiency is also the reason why tomatoes have no flavor despite looking beautiful tomatoes.

yara.it/concimi-e-biostimol...

Solution:

Minerals is one of the reasons why we consume fruit and vegetables.

Don't buy or eat fruit or vegetables that have little flavour, they are probably deficient in minerals .

This obvious, I know, but try to practice it all the time, your greengrocer will hate you..😁

For lovers of the genre: My potted tomato to the delight of my mother-in-law.

[Bolt_Upright in reply to Gioc]

I hear your Lake Como celebrity neighbor is leaving you. Less paparazzi soon?

[Gioc in reply to Bolt_Upright]

youtu.be/iu4fH51Z-ZI?featur...(Not working as expected?)

Yup

😂😂😂

[Gioc in reply to Bolt_Upright]

It seems that he is moving there near , Villa Aurelia in Lierna, Como Lake. Cost 110 M $.

youtu.be/Ma1iMgIYlYc?featur...(Not working as expected?)

[chartist in reply to Gioc]

One indication that you are intaking insufficient boron is osteoporosis. Another indication of low boron levels is if you have osteoarthritis as discussed in the following links :

medicalnewstoday.com/articl...

A relevant article quote :

' A 2015 review of the benefits of boron found that greater boron intake (3–10 mg a day) was associated with fewer cases of osteoarthritis, reducing cases by as much as 60%Trusted Source. The review also found that people with osteoarthritis had lower concentrations of boron than people without osteoarthritis. '

As regards osteoporosis :

healthcentral.com/condition...

A relevant article quote :

' Studies suggest that boron is important for calcium metabolism. In addition, it has proven to be an effective mineral for the treatment and prevention of osteoporosis because of its ability to activate important vitamins and minerals in the body. '

Sometimes low boron intake may be seen in large areas where soil boron content is low such as in an area of Nova Scotia, as discussed here :

novascotia.ca/agri/document...

A relevant article quote :

' In sensitive crops, boron is important in reducing nutritional disorders that affect marketability. Boron moves easily in the soil (leaches) so fields with low boron levels should receive annual applications when growing sensitive crops. Most fields in Nova Scotia have low levels of boron. '

In contrast, in areas of Nova Scotia where soil boron content is known to be low (the south), arthritis is much more common :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant quote :

' The prevalence of arthritis in the three northern territories ("North") is 12.7% compared to 20.1% in the provinces ("South") and is higher among females than males in both the North and South. The prevalence among Inuit is lower than among other Aboriginal groups. Individuals with arthritis are more likely to smoke, be obese, have concurrent chronic diseases, and are less likely to be employed. Aboriginal people with arthritis utilized the health care system more often than those without the disease. '

I can certainly understand why these people are more likely to be obese and have other chronic diseases because once your arthritis gets to the severe stage, you don't want to exercise in any form or even move, because the pain is so great. In such cases, the ability to get boron rich foods may be almost impossible. In such cases, it may be more practical to supplement boron.

Art

[LAJ12345]

I always watch everything on 1.5 x speed and slow it down if I need to pay extra attention!

[MBAnderson in reply to LAJ12345]

Not worth it unless you are considering taking it

[LAJ12345 in reply to MBAnderson]

Na.

[MBAnderson in reply to LAJ12345]

smart

[MBAnderson in reply to MBAnderson]

I have Parkinson's and haven't seen , nor heard, any evidence this stuff would benefit pwp.

[MBAnderson in reply to MBAnderson]

PS. Everything that Mercola says in his intro is contradicted by the video bolt_upright posted, as is much of what Lima says.

All the studies Lima refers to are in animals..

ncbi.nlm.nih.gov/books/NBK5....

[SilentEchoes in reply to MBAnderson]

They don't study cyanide poisoning in ppl. MB is in every anesthesiologists cart. Oh, and our blood supply - all donated blood has MB added to it to kill HIV. You have more reading to do.

[MBAnderson in reply to SilentEchoes]

While I don't doubt what you say, my concern is it has no value for pwp and what I've read and seen so far, it is potentially harmful. Too much causes Serotonin syndrome..

[MBAnderson in reply to MBAnderson]

This one is only 10 mins

youtu.be/RPSFy9doSrA?si=TL9...(Not working as expected?)

[Efka]

Great share thank you! Chris Masterjohn has produced many useful detailed analysis on many topics.

[MBAnderson]

Even pharmaceutical grade Methylene Blue is contaminated with arsenic, aluminum, cadmium, mercury, and lead.

He speculates that the contaminants are harmless because of small amounts, but since when did a small amount of mercury or lead become harmless?

at 8:46

youtu.be/LwXszYVNwa4?si=MMe...(Not working as expected?)

[MBAnderson]

From the Mayo Clinic

"Using this medicine with any of the following medicines is not recommended..."

Amitriptyline

Amoxapine

Amphetamine

Atomoxetine

Benzphetamine

Bupropion

Carbamazepine

Carbidopa

Carbinoxamine

Citalopram

Clomipramine

Codeine

Cyclobenzaprine

Desipramine

Desvenlafaxine

Deutetrabenazine

Dexmethylphenidate

Dextroamphetamine

Doxepin

Doxylamine

Duloxetine

Entacapone

Escitalopram

Fenfluramine

Fluoxetine

Fluvoxamine

Hydroxytryptophan

Imipramine

Isocarboxazid

Levodopa

Levomilnacipran

Linezolid

Lisdexamfetamine

Maprotiline

Meperidine

Methamphetamine

Methylphenidate

Milnacipran

Mirtazapine

Nortriptyline

Ozanimod

Paroxetine

Phenelzine

Phentermine

Protriptyline

Pseudoephedrine

Rizatriptan

Safinamide

Selegiline

Serdexmethylphenidate

Sertraline

Solriamfetol

Sumatriptan

Tapentadol

Tramadol

Tranylcypromine

Trazodone

Trimipramine

Tryptophan

Venlafaxine

Vilazodone

Viloxazine

Vortioxetine

Zolmitriptan

mayoclinic.org/drugs-supple....

[Fumaniron in reply to MBAnderson]

I was just about to mention how are people able to take it Sinemet?

[MBAnderson in reply to Fumaniron]

Not, according to the Mayo Clinic

[Discogs_discogs]

I don't know whether this carries any weight, but this person seems to suggest that methylene blue is not good for your gut bacteria:

l.facebook.com/l.php?u=http...

[Bolt_Upright]

Wow! Thanks for sharing!

"Join Wholistic Wisdom Live Episode 37 as I interview Dr. Sabine Hazan (a top gastroenterologist, researcher, and clinical trial expert) to discuss the potential consequences of Methylene Blue and how it impacts the microbiome.

Since the pandemic, the number one searched product on the internet has been Methylene Blue. While I was very hesitant at first, I too took it for about 4 months last year. While I did notice improvements initially with brain clarity, it also caused severe GI symptoms. And that's when I reached out to Dr. Sabine and she suggested to test my stool to see what was going on.

What we found in my case and many others was that Methylene Blue is killing the bifidobacteria and harming the microbiome. It's important to understand that anything and everything you eat, take, apply, and inject ends up in your gut. And once damaged, it can take at least a year to heal. Whenever a new product takes the world by storm, it's so important to test the microbiome before and after taking it to make sure it isn't doing more harm than good in the long-term."