Edit 3 June 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...
"methylene blue oral and levodopa oral
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
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So I am one month into Methylene Blue. I take about 10 mg a day.
I have not been diagnosed with PD. I have REM Sleep Behavior Disorder and a poor sense of smell and a sore left shoulder and sore left leg and frequent/occasional involuntary movements. I also take SSRIs, which some literature says you should not be using if you are taking Methylene Blue. Do your own research on that and reach out if you want to.
Is MB helping? I don't know. I take a lot of things. My sense of smell is noticeably better (maybe that is just springtime). My face dandruff and dandruff has almost totally gone away (those flakes falling off my face always brought me down). Significantly reduced involuntary movements. Fine motor seems better. And my sore left shoulder used to ache all the way down to my upper forearm, but now the ache only makes it two thirds of the way down my upper arm. All subjective stuff. Maybe it is the regular waxing and waning.
I wanted to share some things I learned:
Cheap MB: USP Grade Methylene Blue Powder - 5 gm (mine came in 5 separate 1 gram vials. Sweet. Also includes a measuring thingy for once you have a liquid) amazon.com/gp/product/B08JL...
How I mix and measure: One gram of powder into 100 ml of water means each ml of water has 10 mg of MB. So I took a little jar and put 100 ml of water in it (I used tap water. Not sure if that is optimum, but it seems to work) and I marked the 100 ml line with a rubber band (in hindsight I really did not need to do that, but I kind of like it). I added one gram of powder to the water, put the lid on and shook it up, and presto! I have MB juice! Then I have another little 4-6 ounce jar I drink out of. I put water in that jar, and then use the suction thingy to get 1 ml of MB out of my MB jar and squirt it into the water that I am going to drink (this is much better than counting drops like some suggest). Then I drink it down. I try to do this in the morning as MB activates NRF2 and NRF2 boosts the circadian rhythm.
I plan on sticking with MB for quite a while. I don't know if it is possible to stop the damage going on, and I am even less sure if it is possible to repair damage. But I am pretty sure that if either is possible, it will take a while (I have a High School degree).
Here are pictures of my jar of Methylene Blue and my suction thingy (you can get a suction thing at the drug store that will measure ml also). I keep this stuff in a dark closet:
I wish I could have bolded "Is MB helping? I don't know. I take a lot of things." It is odd that you can format replies but not the original post.
So... no, I don't know what is helping. And it is subjective. I just know that I will stick with it because: A) If it helps, I figure it will take awhile, and B) 5 Grams is a lot of MB. At my rate of consumption I have 500 days worth
Hubby had to stop it. Didn't see any difference plus the toilette bowl turned blue. However, what has made a tremendous difference is umPEA with Lut. He took his 1/2 t of Sinemet with two MP caps at 2:00 pm with umPEA and Lut. He didn't need any levodopa until almost 8:00 pm! Talkative and his gait was a lot better. We are sticking with this combination, following the trial.
I've recently been giving my HWP umPEA powder (same brand as Bolt_upright uses) but I didn't know about adding luteolin.Despe, the links to the products you mentioned aren't working for me. I think this may be because I'm in the UK. I shall have to look further at Luteolin (I may message you privately about that), but thanks for the product suggestions. Good to know that umPEA seems to be working for your husband 😊 How long before you noticed?
About 2 weeks into the umPEA and Lut, I noticed improvements. What I am looking forward to seeing is possible correction of his posture. He leans forward a lot and when we go out for a walk, he speeds a lot and can't stop. I have him rest his arm on my shoulder to slow him down. Posture is EVERYTHING!
Hi Bolt. Someone recently posted about the contraindication of taking MB with levodopa. I’m unable to locate that post and wonder if you may be able to find it. I am very interested in trying MB as you are doing but am also taking levodopa so I’m concerned. Thank you!
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process levodopa properly.
What might happen:
You may experience an increase in the toxic effects of levodopa including extremely high blood pressure, blurred vision, and muscle twitching. ' <<<
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
I got so busy posting warnings I neglected to thank you Deborah for raising the alarm. Thank you!
It would be nice to find an expert that could weigh in on how much oral MB would put a person in LC in the danger zone. I know Dr Ken Gillman is an expert and for SSRIs he seemed to indicate that 200 mg of oral MB could put you in the danger zone. He did not say less than 200 mg is safe with SSRIs and he did not mention LC.
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
1: I chose my 10 mg dose based on: A) Dr Mercola says he takes 20 mg. B) I am on Prozac so I am trying to keep my dose low. C) In an AD trial in 2016 they gave the control group 8 mg of MB just to turn their pee blue so they would not know they were the control. They figured 8 mg would not have any effect. Turns out the 8 mg dose worked just as well as the 150 mg dose (and with no side effects): healthunlocked.com/cure-par...
2: I take MB on an empty stomach in the morning. MB is a NRF2 activator. NRF2 boost the circadian rhythm. Circadian rhythm peaks at about 1-2 PM. I think boosting the circadian rhythm should be done on the upstroke.
3: I have noticed they sell MB at .1 percent. I just know I want 10 mg. 1 gram into 100 ml makes 10 mg per ml. Simple and easy. I can just draw 1 ml instead of drawing 10 ml if I was using a liter of water. I squirt my 1 ml into about 4 ounces of water and drink it that way.
I take 1g b1 hcl along with a methylated b complex in the morning, then 20mg melatonin at noon, then 300mg niacin NA post lunch, then 500mg curcumin with 30mg melatonin before bed with 1tbsp mct & 1tbsp coconut oil.
Confused about when and how to include MB in this mess?
You can't get sprouts? I sprout my own. It is easy and fun. I sprout broccoli and daikon radish and have about 40 grams of broccoli sprouts and 20 grams of radish sprouts a day.
Yes. In the morning. Sulforaphane activates NRF2, NRF2 boosts the circadian rhythm, circadian rhythm peaks around 1 or 2 PM. I think we should time our boosting of the circadian rhythm so we are doing it on the upstroke.
How unfortunate that we cannot take MB if we're taking levodopa. So many of us PWP's, myself included, are desperate for anything to fix the fatigue problem.
For what it's worth, octacosanol came to my attention as something "used to improve exercise performance including strength, stamina, and reaction time." It was said to be of benefit in Parkinson's Disease, but carries the warning not to be mixed with levodopa.
The gains you describe are similar to mine when I take niacin. I take a lot more but occasionally every two to three months for 20 days with all the other vitamins and minerals. My variation of an anti-aging protocol (d.a.n.i.) of an Italian doctor. All very experimental. I don't recommend it , much better that you do.🍦😁
+* 6/11/2022 Service communication: I sent you a private message but it would seem that this line is not working.👋
My source is liquid drops. 1 drop is 1.5 mg. So 10 drops 15 mg. It’s suggested to work up to 15 mg twice a day. I’m small! I’m peeing blue/ green so backing off a little. Open to suggestions! Especially when to take. I want it first thing then again later in the day. I too take a lot of remedies including Traditional Chinese Herb tea twice a day I have to fast 1 hr before and after
As of 6/21 I am taking a break from MB. I started at 5 mg 4/29, went to 10 mg 5/8, and my REM Sleep Behavior Disorder has been way worse as of 6/16.
I had also started Betaine 6/12 so I stopped that also on 6/20.
I don't know if MB is the issue. I was a bit hesitant to start MB only because I was doing so well before I started that I thought maybe I should not rock the boat. Maybe I should have listened to my gut.
Edit 3 June 2022: Yikes! According to RXlist.com you should NOT take Methylene Blue and Levadopa: rxlist.com/drug-interaction...
"methylene blue oral and levodopa oral
methylene blue oral and levodopa oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Combination may cause severe harmful effects. If methylene blue must be taken, stop taking the serotonergic drug until 24 hours after finishing methylene blue or after 2 weeks of observation for side effects."
I started with 5 mg just to see what might happen (I am on Prozac) then moved to 10 mg. I chose my 10 mg dose based on: A) Dr Mercola says he takes 20 mg. B) I am on Prozac so I am trying to keep my dose low. C) In an AD trial in 2016 they gave the control group 8 mg of MB just to turn their pee blue so they would not know they were the control. They figured 8 mg would not have any effect. Turns out the 8 mg dose worked just as well as the 150 mg dose (and with no side effects): healthunlocked.com/cure-par...
I am not on any PD meds. But I am concerned about methylene blue safety profile, and what should be my starting dose, and how far can I increase it up to?
If you are taking it because Mercola says he does, that would be the worst reason possible. He says he's taking it because he sells it. He says that about everything he sells.
Check him out. More serious negative stuff about him than any other health guru on the internet.
He promotes himself as a medical doctor which he is not.
"... Melatonin Sleep Support Spray ($21.94 for three 0.85-ounce bottles) to Organic Sea Buckthorn Anti-Aging Serum ($22 for one ounce)—as about trying to inform.
"Your tampon “may be a ticking time bomb,” —but you can buy his “worry-free” organic cotton tampons for the discounted price of $7.99 for 16.
Steven Salzberg, a prominent biologist, professor, and researcher at the Johns Hopkins University School of Medicine, calls Mercola “the 21st-century equivalent of a snake-oil salesman.”
"...the FDA demanded that Mercola cease touting a thermographic screening he offers—which uses a special camera to take digital images of skin temperatures—as a better and safer breast cancer diagnostic tool than mammograms.
"... the Better Business Bureau has tagged Mercola.com with an F rating, its lowest, due in part to customer complaints that the company doesn’t honor its 100 percent money-back guarantee. "
"He even advocates something considered outright heresy to most skin doctors: the use of tanning beds. Specifically, he recommends the Mercola Vitality Home Tanning Bed—on sale at his site for $2,997 (“Incredible Deal!”)"
Essentially, it can't be taken with any common drug. It is contraindicated for 135 drugs (at a severe reaction level) meaning it probably should be considered a dangerous drug.
"... may precipitate serious serotonin toxicity, serotonin syndrome, if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitor..."
Why be dinking around with it since it does nothing special?
And then there is this Francisco Gonzalez-Lima guy: peterattiamd.com/franciscog... This is a podcast. He seems to think MB might help with vascular issues in the brain.
Mate, I would like to thank you for putting me on to this. I have just started my 2nd vial and am feeling noticeably better. Nearly no PD indications other than memory.
That is good to know. You are welcome. I am back taking MB. I have a 1 gram to 100 ml solution in a CBD oil squirt bottle and have 10 squirts in the morning and 10 squirts at night. I an following the advice of this person who suggested to just take enough that your pee changes color.
I'd been doing red light therapy, taking numerous supplements, and fast walking for an hour 3x weekly and had improved dramatically. Since MB the slight shakes have stopped and I can write legibly again. I'm still doing everything I previously did but I now feel normal.
I forgot to mention that I have been taking Mannitol as it kills off alpha synuclein (which misfolds neurons) and MB actually kills off "tau" another neuron destroyer.
This combination may be a major benefit in PD treatment.
Its worth trying for a few months. I'm not sure that adding MB to my protocol is the main reason for improvement but it has been the only change and I am back to normal (I believe).
Nothing from specialist or GP. Neither of them were aware that alpha synuclein climbed the vagus nerve and crossed the Blood Brain Barrier to misfold neurons though there is plenty of scientific research toprove this.
Lunch smoothie includes Budwig flaxseed oil and cottage cheese (prostate cancer) then mercura pruriens, mannitol, Lion's mane, beetroot, blueberries, cinnamon, Pomegranate juice to make it fluid. I did include L-Serine but am having trouble finding a reliable source (will never try India again). B1,3 &12, CoQ10. I occasionally add Brahmi and Amla to the smoothie.
Have been using the red light helmet from the Men's Shed in Tasmania as well as a PEMF mat, and John Pepper's fast walk 3x weekly.
Thanks Art. By the way you are a hero of mine as your articles are in basic English I can understand. Thank God for the conclusion of this one which is written in English. The rest may as well be ..... . Your article in Earth Clinic on MB was great.
With my prostate cancer I have been taking DCA, Ivermectin, Low Dose Naltrexone, and Gumby Gumby and I'm hoping that when I go in for my biopsy next month I will be clear. I have had a lesion on my prostate that over 3 years has gone from 10mm to 12 mm to 11 mm and the specialist said it was 80% cancerous. I was quite happy to have it treated but as a public patient in rural Queensland, Australia, they won't do a thing unless it is 100% diagnosed by biopsy. The prostate is double its correct size and makes peeing difficult with sleep interruption but I am taking grape seed extract and this reduces peeing to 3-4 times nightly rather than 5-6. I have also started taking 2mg melatonin to help me sleep.
If you have any further advice I would really appreciate it.
It sounds like you have it well covered! The DCA is fairly potent and any potential peripheral neuropathy is usually reversible with proper supplementation once the treatment is done.
For the enlarged prostate, pumpkin seed oil(PSO) may help and seems worth a try in order to get better sleep. The usual beta sitosterol and saw palmetto may be additive to the PSO
Hi Bolt, I just ordered some Methylene Blue and am researching the contraindication for SSRI's, particularly Levodopa. I see that you take MB and SSRI's apparently without a hypertensive crisis. It seems that carbidopa has been reported to prevent or blunt the hypertensive response. Are you able to share any insights or research with me?
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Methylene Blue for mitochondrial support
Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson’s disease
