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Glycine and N-acetylcysteine (GlyNAC) supplementation?

Bolt_Upright profile image
59 Replies

Can anybody figure out this dosing please? OAs were provided capsules of glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day, provided as N-acetylcysteine [NAC]) . That second link is to a very positive study.

Glutathione and Parkinson's disease: is this the elephant in the room?

pubmed.ncbi.nlm.nih.gov/184...

At least 2 decades have past since the demonstration of a 40-50% deficit in total glutathione (GSH) levels in the substantia nigra in patients with Parkinson's disease (PD). The similar loss of GSH in the nigra in Incidental Lewy body disease, thought to be an early form of PD, indicates that this is one of the earliest derangements to occur in the pre-symptomatic stages of PD. Oxidative damage to lipids, protein and DNA in the nigra of PD patients is consistent with the loss of the antioxidant functions contributed by GSH. Past clinical trials that have used an antioxidant approach to treatment have used antioxidants that might substitute for GSH but these have shown modest to little benefit. More recent studies of the functions served by GSH in cells include in addition to its well-known participation in H(2)O(2) and toxin removal, such roles as modulation of protein function via thiolation which may control physiological and pathophysiological pathways to include DNA synthesis and repair, protein synthesis, amino acid transport, modulation of glutamate receptors and neurohormonal signaling. These multifunctional aspects to the workings of GSH in the cell would suggest that its loss perturbs many different processes and that replenishment and maintenance of GSH per se may be the best approach for preventing progressive damage from occurring.

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

onlinelibrary.wiley.com/doi...

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Bolt_Upright profile image
Bolt_Upright

Baylor College of Medicine holds a patent on GlyNAC, which has been licensed to Nestlé Health Science. GlyNAC is marketed in the United States by Nestlé Health Science under the name CelltrientTM Cellular Protect.

nestlenutritionstore.com/ce...

Bolt_Upright profile image
Bolt_Upright

I think I found my answer on reddit. This is a lot of pills: those dosages would amount to 7 g of glycine and 9 g NAC per day for a 70 kg (155 lbs) adult.

Bolt_Upright profile image
Bolt_Upright

Well I am going to take 1000 mg of Glycine and 1200 mg of NAC. That should do something. Disclaimer: I have a High School Degree.

Astra7 profile image
Astra7 in reply to Bolt_Upright

Sounds like a good place to start. Please keep us updated.

LAJ12345 profile image
LAJ12345

I think 7 g glycine may not be too hard to get from food

bookish profile image
bookish

Thanks for that, some interesting studies. I don't have PD but do use glutathione (autoimmunity etc).

Dr Mark Hyman says that about half of his (chronically ill) patients are missing glutathione genes. As far as I can tell this isn't necessarily an issue, as absent genes are common and most have other glutathione pathways which seem to compensate. Genetic SNPs still have to 'express' so having them doesn't mean you have a problem, nor does not having them mean you cannot still develop one. I wonder though whether those who have the absent gene(s) like myself are perhaps a little less able to be metabolically flexible when put under a variety of other stressors over a long period of time.

According to Micki Rose (purehealthclinic.co.uk), glutathione deficiency can be caused or exacerbated by chronic food reactions, poor diet, sleep loss or anything that keeps the immune system hyped-up (infections, inflammation etc). Straight glutathione isn't good at increasing cellular levels although reduced glutathione helps (that is what I'm on) as well as the precursors, like NAC, selenium, Vit C and sulphur foods (broccoli, onions etc). Taking a mix is believed to work better than sticking to just one form and you can downgrade absorption by taking too high a dose. She suggests 100-200 mg daily or in extremis 200mg every 2 or 3 hours to a max of 2000mg (NAC). Cheers

Bolt_Upright profile image
Bolt_Upright in reply to bookish

Yes, I read glutathione gets digested in the stomach. What is reduced glutathione?

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

Here, let me DuckDuckGo that for me: glutathionepathway.com/what...

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

Glutathione supplementation: Does it work? FORD BREWER MD MPH

youtu.be/2vvj_NCxg0c

He does mention Dr Mark Hyman and selenium too.

Bolt_Upright profile image
Bolt_Upright in reply to bookish

I should add: Thank you so much for your reply. Lots of good information you provided. I only provided the video link as it was about reduced glutathione. If that is working for you, that is great. I will continue to research it. Thanks.

bookish profile image
bookish in reply to Bolt_Upright

Hi, thanks so much for both your links. It is always good to get a different viewpoint and re-challenge yourself on what you are doing and why! After a while it is easy to forget (I find, anyway).

I didn't go into more detail on what I take as it didn't seem to be appropriate as I don't have PD but other neuro and autoimmune stuff. Basically I am doing pretty much all that was on Mark Hyman's print out in the video. Datis Kharrazian distinguishes between the need to improve glutathione recycling and raise glutathione intake drknews.com/glutathione-rec....

I've actually been using Setria glutathione in a supplement called Kirkman's Detox Aid which includes selenium, calcium d-glucarate, l-taurine, olive leaf extract, milk thistle, turmeric and alpha ketoglutaric acid about which they say "This updated version contains alpha ketoglutaric acid as a replacement for n-acetyl cysteine (NAC), which may have side effects in a subset of individuals." Unfortunately they have recently reformulated and can no longer guarantee that the new glutathione used will be corn free so I may be having to look elsewhere (multiple chemical and food intolerances).

When I did my genetic and hepatic test I was actually looking for signs of poor methylation (family history, especially dubious B12 and folate useage) and started using methylated versions (small amounts of B6, moderate methyltetrahydrofolate and more methylcobalamin). These have made a huge difference to some (not all) of my neuro symptoms. I use vit C and E, magnesium, and eat my broccoli! Lifestyle and diet changes have been key and I continue to work on gut, liver, brain, immune system. Just started watching Peter Kan's BIG Idea masterclass (bigmasterclass.com/) and already have some ideas of more tweaking in my approach. Best wishes

Bolt_Upright profile image
Bolt_Upright in reply to bookish

I will check out that video.

Wondering your view on vitamin C. In one group they say ascorbic acid vitamin C is bad and not even really vitamin C and you should take whole food vitamin C (which cost a lot more).

bookish profile image
bookish in reply to Bolt_Upright

I'm not really the best person to ask about vitamin C! I have a corn sensitivity and am completely grain free. The vast majority of vitamin C supplements are corn-derived (can be fermentation/extraction etc) and even the cassava based ones use some corn in the processing and I don't react well. So I am very limited, to sugar beet basically, and I use a buffered ascorbate that I can tolerate. I empty it out of the HPMC capsule to avoid carrageenan. Life is such fun!! Some use acerola cherry juice but that is expensive too. I'm not sure about the whole food ones but if the same as True Food, likely to be fermented from corn. I take what I can and eat oranges/kiwi/parsley and my lifesaver, watercress....!!

Bolt_Upright profile image
Bolt_Upright in reply to bookish

You seem to be the best person to ask about Vitamin C that I have ever asked. You know a lot!

bookish profile image
bookish in reply to Bolt_Upright

Thank you! You just gave me my first chuckle of the day!!

bookish profile image
bookish in reply to Bolt_Upright

One more note that I just found about whole food supplements is that they commonly contain gluten/have wheat as a filler. I'm currently working my way through Datis Kharrazian's huge book on brain function (Why Isn't My Brain Working?) and would recommend it, if you are in the mood. Cheers

Smittybear7 profile image
Smittybear7

How much NAC is needed?

Bolt_Upright profile image
Bolt_Upright in reply to Smittybear7

The best I could tell it seemed like they were taking maybe 7 grams of glycine and 9 grams of NAC a day. I got that by searching on the amounts listed in the study and finding people in forums that did the math. For me, I am only going to try 1000 mg of glycine and 1200 mg of NAC. It's about the same ratio.

chartist profile image
chartist

Bolt_Upright,

This is the reply to the question you asked me in chat :

Bolt_Upright,

I am not your best choice to ask about this specific topic because I feel I may be biased toward melatonin and also feel that melatonin is a more potent antioxidant in the human body than Glycine and NAC combined and I feel that melatonin is very well suited to fighting the multitude of negative effects brought about by PD.

Melatonin up regulates gene expression of many of the bodies own potent antioxidants including glutathione peroxidase, glutathione, Superoxide Dismutase and Catalase, it up regulates Nrf2 expression while down regulating KEAP1 which increases total antioxidant capacity (TAC) in the body which is insufficient in PwP, melatonin scavenges reactive oxygen species, reactive nitrogen species as well as peroxynitrite all of which are at elevated levels in PD, it neutralizes H2O2, it can neutralize up to 10 oxygen radicals whereas vitamin c and e can only neutralize one radical each. Melatonin or it's metabolites can repair a perturbed blood brain barrier (BBB) while easily crossing the BBB itself. Melatonin levels decline sharply with age and may partially help explain why PD is an age related disease.

On top of that, melatonin levels are even lower in PwP compared to non PwP. Melatonin is produced right in the mitochondria and if demand increases beyond production capacity in the mitochondria, the mitochondria can draw melatonin from outside of the mitochondria if there is enough melatonin available, but unfortunately, because of decreased melatonin levels in PwP, there may not be sufficient melatonin available to draw into the mitochondria and then mitochondrial damage is inevitable. Think about this for a moment, why would mitochondria need to generate melatonin from within? I think the reason is because oxidative damage occurs rapidly and in order to limit this damage to tolerable levels, you need a highly potent antioxidant immediately and closely available in the mitochondria to scavenge these radicals instantaneously as they are produced and before they do excessive damage. Unfortunately because of the intense oxidative stress placed on the mitochondria in PD, native melatonin in the mitochondria becomes depleted and melatonin levels outside of the mitochondria are insufficient to be of much help as melatonin levels decline with age.

This is a slow damage process that plays out over a decade or two prior to PD symptoms becoming noticeable, so melatonin does a very good job for many many years in quelling these excess oxidative stress levels in the mitochondria, but once melatonin levels decline beyond sufficiency, the damage to the mitochondria and reduction of ATP gets excessive, the damage to the mitochondria and dopaminergic neurons occurs at a much quicker rate.

You also have to consider that in this instance, we are only looking at what is going on in the Substantia Nigra pars compacta, but the depleted melatonin levels throughout the body are allowing damage to such things as the heart which can potentially explain or partially explain why heart disease and stroke are at increased risk in PwP as I have previously written about on the forum.

Some of this is theory, but most of it is fact, but this is only a partial explanation of why I believe melatonin can be extremely useful for PwP and especially when applied early at a high enough dose.

Art

Bolt_Upright profile image
Bolt_Upright in reply to chartist

Thank you so much Art. What a well written explanation. And I agree with you on the importance of melatonin as one prong in the multi-pronged thing used to deal with PK (or in my case, REMSBD). In fact, I just took my melatonin (only 5 mg. I need to build up my dosing).

I read you post on FMT today. I believe fixing the microbiome is also one of the main prongs in our pronged weapon (spear-fork?). In fact, here is a clip from the godfather of FMT Dr Borody talking about the morality of control groups and clinical trials and the fact that it took 3 drugs to stop AIDS. It's good stuff: youtu.be/POfIMGS2D6A?t=243

These are the prongs of my multi-pronged thingy so far:

1: Fix the microbiome.

- PwP have distorted microbiomes and new theory is the dysbioisis in the microbiome may be feeding the PK.

- FMT is one option to fix the microbiome. If I could get some poop pills I'd be popping them right now!

- I read a study that the Specific Carbohydrate Diet on its own could bring the microbiome back to normal, assuming your gut contained the needed spectrum of flora. SCD will starve the bad bacteria. I practice a combination of Wahls Paleo Plus Keto and SCD. Basically SCD Keto.

- I chatted with somebody who did FMT and she went SCD before the FMT and stayed on the SCD. It makes sense. Why dump good poop into a cesspool of pizza and beer?

- My respect for the SCD is why I am not considering Mannitol. Mannitol is not allowed on SCD. It is not easily absorbed and feeds the bad bacteria.

- Taking TUDCA: TUDCA attenuates the progression of HFD‐induced NAFLD in mice by ameliorating gut inflammation, improving intestinal barrier function, decreasing intestinal fat transport and modulating intestinal microbiota composition.

ncbi.nlm.nih.gov/pmc/articl...

So fix the microbiome, maybe stop the ongoing damage. But we still need to undo damage if possible.

2: Melatonin:

- Daily bedtime administration of 3–12 mg of melatonin has been demonstrated effective in RDB treatment and may halt neurodegeneration to PD.

ncbi.nlm.nih.gov/pmc/articl...

- I know, I need to go higher. I know somebody who takes 50 mg a day.

- I think melatonin helps with microbiome dysbiosis also.

3: Glycine and N-acetylcysteine (I have not started yet. It is in the mail. And I am not going to try the doses in the trial (7 and 9 grams I think)

- Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial.

onlinelibrary.wiley.com/doi...

4: B1 Thiamine HCL 500 mg a day (early).

- 1: There is a high dose Thiamine HCL group for PK. 2: Is good for the microbiome.

5: Magnesium LThreonate - Oral Magnesium Compound Able to Reach Brain Seen to Slow Motor Decline, Neuronal Loss in Early Study. parkinsonsnewstoday.com/201...

6: Keto Diet: It is plausible and safe for PD patients to maintain a low‐fat or ketogenic diet for 8 weeks. Both diet groups significantly improved in motor and nonmotor symptoms; however, the ketogenic group showed greater improvements in nonmotor symptoms.

ncbi.nlm.nih.gov/pmc/articl...

7: Exercise - The intensity has to be at least half of your maximum capacity and sustained for twenty minutes three to four times a week. Supposed to increase mitochondria count I think.

8: Ambroxol - I can't afford to take 20 of these tabs a day forever, but I can afford to take 20 a day for 2 weeks 4 times a year. That might help clean up some a-synuclean.

Can you tell I only graduated high school? Anyway, I think melatonin is a critical pillar in the (currently) 8 legged stool that is my multi-pronged thingy.

Dave

chartist profile image
chartist in reply to Bolt_Upright

B_U,

You covered a lot of ground right there! Whenever I am writing about possible things to take for PD or anything else, I also try to consider how doable it is for the majority of people to follow a supplementing regimen. I can see that you will do your best to follow your 8 pronged approach because you are highly motivated to do so and are very proactive plus you are research oriented. I see all of the potential benefit you see in this approach, but I think for the majority of PwP, especially at advanced stages, it would be difficult if not impossible for them to do that. I would say that you are in a similar frame of mind as MBAnderson who has said something along the line of he will take almost anything if it has shown the potential to help and not hurt.

Every step you mention is likely to offer benefit to varying degrees with some items offering significantly more benefit than others. I can see where many would be able to handle FMT, melatonin and exercise and I believe that combination could be very useful in terms of reducing symptoms and improving overall health. Once those benefits are achieved, I think it would then be easier for the majority to consider adding another prong from your 8 pronged approach such as some form of diet or intermittent fasting. Beyond that it will be less and less people who will be able to follow such a plan.

Btw, please don't take 7 or 9 grams of NAC as that is too harsh on the gut and I think it could potentially cause harm fairly quickly.

If you end up doing the full 8, please give us updates as you go!

Art

Bolt_Upright profile image
Bolt_Upright in reply to chartist

Thanks Art. My (uneducated) plan for Glycine/NAC is 1000 mg glycine and 1200 mg NAC. It's about the same ratio as in the study, but at about 20% (best I can tell) of what the study used. In the study they had old people performing like young people on the huge doses. I am not looking for YP performance, just normal OP performance. Plus, as part of a multi-pronged approach it seems to me I should not have to lean so heavily on this one thing.

I will provide updates. Thanks.

Smittybear7 profile image
Smittybear7 in reply to Bolt_Upright

Who can I get to prescribe a list of what to take and how much? I am in Pittsburgh PA working with a nutritionist/pharmacist. Not happy with the way he is working. Presently taking b1,co q10,d3,cortisol high (homeopathic) multivitamin and minerals,ultrazyme, magnesium, dopa plus (pure encapsulation) mega Sporebiotic, omega 3d,dha vitaminc,, I think I may start on oral glutathione. Any recommendations for someone in Pittsburgh PA who could help would be appreciated.thanks

faridaro profile image
faridaro in reply to Smittybear7

Before starting on oral glutathione I would recommend to watch Dr. Ben Lynch's video interview where he also talks about NAC:

youtube.com/watch?v=0XhldPh...

Bolt_Upright profile image
Bolt_Upright in reply to faridaro

Great video faridaro. Thanks for sharing.

Bolt_Upright profile image
Bolt_Upright in reply to Smittybear7

Hello Smittybear7, I should be starting every post with "I only have a High School Degree".

Also, I have been looking into this stuff for less than 3 months.

It sounds like a good thing that you have a nutritionist/pharmacist. I am sure he is much smarter than I am.

I'm taking a couple studies that were done on over 50 HIV patients and old and young people and projecting that GlyNAC might work for PK. Speculation layered on ignorance and desperation. It still makes sense to me, but I don't even know what re-uptake means.

Maybe forward the linked studies to your nutritionist/pharmacist. I know NAC is in Restore Gold, so that seems to at least be in the ball park of good ideas.

Good luck with your treatment.

I don't have PK. I have REM Sleep Behavior Disorder and if you Google that you will figure out why I am in this group.

I will keep posting updates. I listed my 8 pronged attack plan in this string, but please remember that I am not a smart man.

Bolt.

Smittybear7 profile image
Smittybear7 in reply to Bolt_Upright

Nutritionist/pharmacist has suggested drdatta neurotransmitter test comprehensive test is about $400Shorter test $250. I'm going to try to research it. When he muscle tested me gaba and serotonin came up. Not sure what that means.

I think you're smart and thanks for your input .

sharoncrayn profile image
sharoncrayn

triple check your calculations. you (or reddit or both) are mistaken. close but not close enough.

The molar mass, in general, is different for every substance, and has to be computed or looked up.

You have to multiply by the molar mass of the substance (same as atomic or molecular weight).

i.e. for sodium as an example, 455mmol/kg = 22.99 g/mol =10,460 mg/kg = 10.46g/kg

molar mass for glycine = 75.07 g/mol

glycine study protocol = 1.33 mmol/kg/day = 99 mgs/kg (1.33x75.07)

now do your own math (try not to use a unreliable source like reddit or similar forums; it is a bad habit. most of the time they don't know)

sharon

Bolt_Upright profile image
Bolt_Upright in reply to sharoncrayn

Thank you for the guidance Sharon. I did the match and at 72 kg that seems to come up to about 7 grams of glycine. And the NAC has a higher molecular weight. Seems like too much to ingest.

Bolt.

sharoncrayn profile image
sharoncrayn

further, you and I have no idea why they chose that dose. so why even think about going there unless you can find out. who knows? they don't explain it. perhaps they wanted to assess max dose tolerance? toxicity? safety? did they split the dose? how many splits/24 hours? etc.

were the improvements "significant"? some were; some were not so significant. too small a study to draw a significant, general conclusion...n=8.

further, if dosing stopped, improvements receded.

"GlyNAC supplementation for 24 weeks corrected GSH deficiency, OxS and oxidant damage, but improvement in GSH and O'xS reverted to pre-supplementation levels 12 weeks after stopping GlyNAC, suggesting that continued supplementation of GlyNAC is necessary for maintenance of benefits."

multiple participant exclusion criteria. therefore, relatively healthy participants.

promising but too weak a study design to look for an elephant.

sharon

Bolt_Upright profile image
Bolt_Upright

There were actually 2 studies I found.

Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients

ncbi.nlm.nih.gov/pmc/articl...

sharoncrayn profile image
sharoncrayn in reply to Bolt_Upright

"In an open-label design, 8 older GSH-deficient HIV-infected males were studied before and after 14 days of oral supplementation with the GSH precursors cysteine and glycine. "

very weak design. no specifics on several outcomes (i.e. strength gain), too small, too short, etc.etc.

sorry, but both studies are very rudimentary (2008, 2014). I don't find any follow on, larger, better designed studies (now into 2021) to validate this hypothesis (oral supplementation with 0.81 mmol/kg/d of cysteine (as N-acetylcysteine) and 1.33 mmol/kg/d of glycine). apparently a dead end or not enough interest.

sharon

Bolt_Upright profile image
Bolt_Upright

New research provides further evidence that c-Abl activation promotes α-synuclein aggregation & neuronal loss in Parkinson’s models; Also shows that N-acetyl cysteine suppresses c-Abl activation & neurodegeneration (Click here to read more about this).

sciencedirect.com/science/a...

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

These findings show that α-synuclein aggregates induce c-Abl activation by a redox stress mechanism. c-Abl activation in turn promotes α-synuclein aggregation, in a feed-forward interaction. The capacity of N-acetyl cysteine to interrupt this interaction adds mechanistic support its consideration as a therapeutic in Parkinson’s disease.

Bolt_Upright profile image
Bolt_Upright

Dietary Supplement Eases Parkinson’s Symptoms, Improves Dopamine Function, Study Shows - by Catarina Silva, MSc | June 20, 2019

parkinsonsnewstoday.com/201...

kevowpd profile image
kevowpd in reply to Bolt_Upright

28 participants were randomized to receive a combination of daily and intravenous (50mg/kg) NAC for three months, while the remaining 14 were assigned to the control group.

“On the days that subjects did not receive the intravenous NAC, they took 600mg NAC tablets orally 2 times per day,” the researchers wrote. NAC injections were given once a week. “For the duration of the study, both groups continued to receive their current standard of care treatment for PD [Parkinson’s disease],” investigators added.

Subjects had their dopamine brain function and disease motor features evaluated before and after NAC treatment.

Difficulty is replicating this result without IV NAC. How to know the oral equivalent amount, and is that amount safe medium to long term?

Bolt_Upright profile image
Bolt_Upright in reply to kevowpd

Interesting that 600 mg twice a day was what I settled on for my REM Sleep Behavior Disorder. Along with 1000 mg of Glycine with each NAC capsule. I'm winging it.

kevowpd profile image
kevowpd in reply to Bolt_Upright

And how is it going? Ive tried melatonin for REM SBD but i felt groggy in the morn and it didnt seem to help.

Bolt_Upright profile image
Bolt_Upright in reply to kevowpd

It just came in the mail today. I had one of each capsule but my noon and midnight routine starts tomorrow. I think I will drop the idebenone from my routine. I think sometimes anti-oxidants can interfere with each other (based on reading C0Q10 could interfere with Idebenone).

You might keep up a low dose of melatonin. It could be neuroprotective:

pubmed.ncbi.nlm.nih.gov/298...

Bolt_Upright profile image
Bolt_Upright

I have to think this is why they are trying to get NAC off the supplements list. They want to be able to make a fortune selling us something we were getting cheap.

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

ncbi.nlm.nih.gov/pmc/articl...

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

In addition, a further application of NAC is related to a study where this compound has shown to exert an activity as a scavenger of H2O2 and toxic quinones generated by DA, which has also protected the inhibition of Na+, K+-ATPase activity mediated by DA. This indicates an additional mechanism of NAC that encourages its use in PD treatment [78]. Therefore, acting against Na+, K+-ATPase inhibition, NAC may neutralize the death of dopaminergic neurons, which counteracts intracellular damage pathways.

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

I wonder if this table link will work. It shows dosages:

ncbi.nlm.nih.gov/pmc/articl...

Bolt_Upright profile image
Bolt_Upright in reply to Bolt_Upright

This trial they did 6000 mg a day orally (divided between two dosings):

Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

clinicaltrials.gov/ct2/show...

kevowpd profile image
kevowpd in reply to Bolt_Upright

I dont think its that. Supplement vendors can influence government too, remember.

There was some unscrupulous supplement marketers that were pushing nac as a treatment for all types of stuff. This likely attracted the attention of the FDA, who elected to enforce its drug status, which they had previously (evidently) turned a blind eye to. This is why we cant have nice things.

Gioc profile image
Gioc in reply to kevowpd

"There was some unscrupulous supplement marketers that were pushing nac as a treatment for all types of stuff." ? ,,, by NAC? sorry but where did you read this?

Bolt_Upright profile image
Bolt_Upright

This is not too positive, but this is NAC only (6000 mg per day):

Nevertheless, preclinical studies suggest NAC’s potential effectiveness as a PD modi-fier and have led to performing some clinical trials (Table 3). In a trial with Parkinson’sand Gaucher’s disease patients, brain GSH levels were quantified by magnetic resonancespectroscopy after a single intravenous infusion of 150 mg/kg NAC; although GSH wasincreased in all subjects, it returned to basal levels after 120 min [128]. A pilot study wasperformed to evaluate the safety, tolerability, and preliminary efficacy of NAC intravenousand oral administration; the data obtained suggested that NAC might be positively impact-ing dopamine function and potentially clinical symptoms [129]. Each subject was providedwith 3000 mg NAC twice a day (6000 mg total) for four weeks in a prospective study.The results of this study showed that, although repeated oral doses of NAC increased theantioxidants (GSH/GSSG) peripherical levels, the indicators of oxidative damage (lipidperoxidation) remained unchanged, and the GSH brain levels did not increase signifi-cantly [130]. The most recent clinical trial recruited PD patients, who received a combinedoral and intravenous NAC administration for three months. Afterward, patients wereevaluated by SPECT imaging and UPRDS (Unified Parkinson’s Disease Rating Scale) score,which showed that NAC improved dopamine transporter (DAT) binding in PD patients,correlating with improvement symptoms [131].

Lots of good stuff in here: google.com/url?sa=t&rct=j&q...

Bolt_Upright profile image
Bolt_Upright

So my 600 mg NAC 1000 mg Glycine experiment got off to a bad start. I got a couple of brief episodes of tachycardia over the next 12 hours. That is probably not good. Reconsidering options.

JayPwP profile image
JayPwP

Any updates Bolt? Also which Glycine did you take, L-Glycine or something else?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

Yes, a couple weeks ago I tried my 600 mg of NAC again and was fine. So I took it for a week and now I am up to 1200 NAC, 1000 Glycine (Life Extension- Glycine from Swanson's. $10 for 100), and added 1000 Taurine. NAC and Glycine work well together and NAC and Taurine work well together so I take the 3 together about an hour before bed. I read NAC does it's thing while you sleep.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Arent you also taking Melatonin? How do you space out all supplements across the day?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

I take 10 mg of melatonin with my 250 mg of Niacin Time Released before bed. Yes, I space my supplements out. Some things work when you sleep. Some are better with food. I take my Niacin at night because I have butyric acid with my meals and per a professor I corresponded with the butyric acid does some of what the niacin does so I like to keep them separate.

JayPwP profile image
JayPwP in reply to Bolt_Upright

I was asking about your schedule, what do you take, when do you take and how much do you take? I would love to hear that.

JayPwP profile image
JayPwP in reply to Bolt_Upright

Also which Glycine did you take, L-Glycine or something else?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

1000 Glycine (Life Extension- Glycine from Swanson's. $10 for 100)

JayPwP profile image
JayPwP in reply to Bolt_Upright

Thanks. I was confused between glycine and L-glycine, both seem same

KERRINGTON profile image
KERRINGTON

Hi ! Are you still taking 1200 mg of NAC, 1000 mg both Glycine, and Taurine ? Thanks...

Bolt_Upright profile image
Bolt_Upright in reply to KERRINGTON

No, I cut out Glycine a while ago. I think Glycine might make PD worse. I have a High School degree, but I got scared off. Please read this post and read the post this one links to: healthunlocked.com/cure-par...

You may also like...

Glycine : said to reduce symptoms and reduce aggregation

michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine...

Supplement Reverses Hallmarks Of Old Age And Promotes Healthier Aging

This included oxidative stress, glutathione deficiency, mitochondrial dysfunction, mitophagy,...

Vitamin C + Omega 3 Fish Oil Combo

C (100 mg/kg) to improve the oxidative tissue damage and liver functions affected by MTX-induced...

The Endotoxin Hypothesis of Parkinson's Disease

Abstract: The endotoxin hypothesis of Parkinson's disease (PD) is the idea that...

Chlorogenic Acid Adverse, n=1

There are favorable studies of its effect on Parkinson's in animal models. No interventional...