I thought this may be of interest to some or many.
The supplement "Glynac" (combination of Glycine and N-acetylcysteine) showed after 16 weeks of participants taking doses of 100 mg/kg/d each of glycine and NAC, was associated with a host of benefits for key hallmarks of aging and age-associated defects.
This included oxidative stress, glutathione deficiency, mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue, and cellular senescence.
This would suggest that it would have some benefit in people with neurological disorders.
When considering that it improved mitochondrial function, inflammation, stem cell fatigue and cellular senescence; all key markers of neuron-degeneration.
In the comments section of the article one commenter was suggesting that at the rate they suggest a person would be taking several thousand mg of both the glycine and the NAC in a day. If a person weighs 150 lb that is roughly 68 kg so at 100 mg per kg that would be 6800 mg in one day. A search of glycine the highest dose I saw in one capsule was 1000 mg. so 7 capsules would be 7000 mg. The glycine I saw came in bottles of 60 or 100 capsules. The NAC was available in 1000 mg capsules or tablets. At the rate suggested 6 or 7 NAC pills would be taken in one day.
I am not endorsing glynac but what people do is get the powder. It is cheaper. Then you have to weigh your doses (until you can approximate doses by measuring them by volume).
' participants at doses of 100 mg/kg/d each of glycine and NAC, and 200 mg/kg/d of alanine. '
Taking this, they are saying 100 mg per kilogram of bw of NAC. I weigh 80 kilos x 100 = 8 000 mg/day of NAC and likewise it would be another 8000 mg of glycine and 16,000 mg of alanine. I just don't understand how anyone can take this much of these supplements everyday???
No one has to take that exact amount, people should be reasonable in their approach to any supplementation. People could take half and it would be of some benefit, and then adjust accordingly to their own well being.
There is a product that I have ordered which comes in a powder form 1600mg per scoop: NAC + Glycine Supreme | N-Acetyl-L-Cysteine, Glycine and Taurine Combination
Yes, I agree. I was only commenting on the amount actually used in the study which they said was given in capsule form. The total amount of mg used per day with all three supplements was 32,000 mg. Generally speaking, the largest capsules commonly used are 1000 mg of ingredient. If they delivered those amounts all in 1000 mg capsules, you would be taking 32 capsules per day, plus anything else you are already taking. I have taken a lot of supplements at one time, but I don't think I could take that much everyday.
Yes I had done the math on this and it sounded like my husband who weighs 150 lb would be taking about 6800 at that level so I think I was close on the math. He has been taking a little NAC in the past but not taking glycine at all. I don't see how the people on this dose managed to persevere without some significant consequences so it makes you wonder exactly how much they were taking but if you look at the Glynac supplement as it is formulated it does not have that level of either in it and it appears to be quite expensive plus it appears to have other stuff in it. It makes a person wonder what was the goal in this research.
Here is an example of a Glynac supplement that sells for $39.99 per bottle with 60 caps in the bottle with a recommended dose of 2 caps per day. so that is not like what they are suggesting as the dose in the article at all.
DOSAGE: 1 Capsules 1-2 times per day. Each capsule contains 50mg NACET and 525mg Glycine.
Here is a link do the supplement not because I think it is appropriate but just so you can see how it is listed online.
Also since the majority of this supplement is glycine which is not an expensive supplement it seems to me like the price it is sold for is very high considering the ingredients.
"Glycine and N-acetylcysteine and alanine were purchased commercially, and quality verified via certificates of analyses. These supplements are filled into capsules by a pharmacist, and provided monthly to study participants at doses of 100 mg/kg/d each of glycine and NAC, and 200 mg/kg/d of alanine. The participants and the study team were blinded to the identity of the capsules, which were of the same size, shape, color, and taste. Supplement randomization was done using a computerized program provided by the statistician. Compliance with supplementation was assessed with intermittent phone calls, verification at monthly visits and by capsule-counting."
“One of the beautiful things about bone broth is that it contains approximately 27 grams of glycine per 100 grams of protein. Therefore bone broth is a wonderful natural food source of glycine, helping you to obtain your daily requirements.”
Also meat seems to have a couple of grams per 100g meat.
Also gelatine “Gelatin is especially rich in proline and hydroxyproline. According to a food industry website, it contains 15.5 and 13.3 grams per 100 grams of pure protein respectively. It also contains 27.2 grams of glycine per 100 grams pure protein”
Beans and Lentils. Beans contain the amino acids glycine, lysine and proline, and lentils provide lysine. Beans and lentils also contain tons of fiber, which is important for healthy digestion. You can pair various beans and lentils with grains, seeds, nuts, and/or other plant proteins to make up a complete protein.
Do vegans get enough glycine?
For glycine, vegans had the highest concentration and meat-eaters the lowest. Intakes of all 18 dietary amino acids differed by diet group; for the majority of these, intake was highest in meat-eaters followed by fish-eaters, then vegetarians and lowest in vegans (up to 47% lower than in meat-eaters).
Dietary cysteine needs to be actively absorbed in the intestine, while oral NAC can enter the intestinal epithelium by passive diffusion.
Research studies suggest that oral NAC is best taken on an empty stomach or 30 minutes prior to any food, which allows for better absorption. Otherwise other proteins will compete for uptake.
However, this the dilemma part, it can cause an upset stomach, vomiting, nausea and diarrhea if taken on an empty stomach, so some suggest it should be taken with food.
Its best to trial it yourself and gauge your own bodies acceptance of the substance. If successful on an empty stomach then proceed with that method; as this is the preferred method for best results.
Thanks for your post. My pharmacist friend pointed out that in addition to all the benefits for pd glutathione is often really helpful for sleep when taken an hour before bed. I have insomnia so I will give it a try. Since glutathione is naturally occurring it may be a lot safer than the 7.5 mg Remeron recommended by the mds. Best to you!
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