Can C/L and venlaxafine ( effexor/ SSNRI) possibly be the reason I experience some symptoms ?,?

[moparkie715]

I really need some advice. I think perhaps some of my symptoms may be caused by one or more of my medications. I received a DAT SCAN (showed loss of dopamine in the right and left side of my brain) in 2015 confirming that I have Parkinson's but because my progression seems to be faster than most ,my dr said I have parkinsonism ( some PSP qualities)..

I feel like I have every symptom under the sun . My loss of balance and freezing of gait are my biggest problems. I have problems with my speech, my handwriting is illegible, tremors on the left hand and leg. I also have problems with my eyes. I am very sensitive to bright lights, like the sun, and they will close making it difficult to open. I go for Botox shots . They work wonderfully for about a month and then my symptoms slowly start to reappear. I have rigidity on my right side.

I am currently taking

1. CL every 3 hrs , 4x per day ( 8am - 5pm )

2. Selegeline ( between 8-10am)

3. Venlaxafine 1 pill (150mg) 9am

4. I take on occasion calcium & D3, B6, B12, B1, Tumeric,

Always take fish oil, probiotic and magnesium

I have tried the Thiamine B1 hoh dose protocol with Dr. C. I was able to get a few good days but nothing very consistent. I hagetve been trying to clean up my gut and go back to having a dainly BM.. Those things are better but have not bee able to get the correct dose of B1 so I stopped taking it.

I was on Amantadine but had to stop bc it was causing terrible swelling in my ankles and feet.

I feel the best when I get up in the morning. Once I start with the CL, my speech and my walking get worse. And around the time I go to bed Around 10PM i can usually walk a lot better. Not perfect but a bit better.

Questions

#1 . Do I need separate the selegeline dosages by a certain # of hours??. I have been taking selegeline 1x per day , bc if I take it past 1pm. I cant sleep. My dr. knows I only take wi1x per day.

But I have read here y have to take it 2x per day to in order to slow down the progression.

#2. Is it possible for the venlaxafine ( anxiety)to be the root of my gait or balance problems?

I have decreased my dosage from 150mg to 75mg ( w GP) and my legs do not feel as heavy pre taking the medication.

#3. Is it possible for the C/L to affect my speech??

My speech is also not consistent. I have been doing a lot of observing of my body lately and I notice that my speech seems to get worse after each dose of CL.

By 5pm icannot speak comprehensively nor can I walk easily.

Maybe i am crazy, but i was hoping someone could shed some light on these questions.

Thank you so much

Monica

[park_bear]

Hi Monica,

Selegiline is just for symptomatic relief. It is also a mild stimulant. So taking just one dose in the morning is good.

If you can tolerate a little bit of vitamin B1 I think that is better than giving up on it entirely. Also take a look at celery seed extract which I wrote about here:

healthunlocked.com/parkinso...

Since you have got improvement by reducing your venlaxafine, if you are able to reduce it further you may get additional improvement.

Don't know what to day about Q#3

-PB

[moparkie715 in reply to park_bear]

Thanks Park_bear

[aridin1966]

My PWP is on 3 @ 3x a day Rytary ER 36.25 MG - 145 MG. His Internal Med Dr prescribed Effexor 37.5 mg to start. He had a MAJOR interaction the very 1st night. The Neuropsychologist at the Neuromedical Center stated NEVER to take a SSRI or a SSNI with the CL. However, when I checked the WebMD Drug Interaction - it shows 0 interactions, IDK.

[Hidden]

Hi moparkie715:

If you have Parkinson's, you should first (along with your doctor) determine the C/L dosage that relieves your symptoms (I take a wild guess that you are taking too little right now).

Also reconsider taking all of those vitamins/supplements unless they were prescribed by your doctor...

[park_bear in reply to Hidden]

No supplement requires a prescription. Doctor's time is parceled out by the minute. No doctor would take kindly to a request to write such a "prescription". This is common knowledge. Therefore you are suggesting something you ought to know is not possible.

[Hidden in reply to park_bear]

Hi park_bear: Once a doctor wrote me a prescription for vitamin D once, so I do think it is possible... I guess they have stronger doses... But it is not an important part of what I wanted to say in that sentence, which was that she should have a discussion with her doctor about the vitamins/supplements she is taking and if they are beneficial/necessary/safe...