Does anyone have any suggestions for cramp in the calf muscle? I have suffered periodically for years, I wake up in the night in excruciating pain and my leg will be sore for 2-3 days afterwards. It hasn't happened for some time now, but since taking up c25k I can feel something is going on with the muscle. I always try to stretch after the runs, but maybe it's not for long enough. I've also tried tonic water with quinine but not sure if this works or not.