Hubby is in remission but still needs to take his A&V for an additional 8.5months.

[spi3]

Great news! Yesterday we were informed that my hubby was in remission. His has ZERO CLL in his blood and all of his lymph nodes and organs are normal. However, his BMB test reflected a MRD = 0.088%. His Dr stated that at a microscopic level there is CLL and by taking his Acalabrutinib and Venetoclax for the remaining cycles (8.5 months more) there will be absolutely no CLL in his bone marrow. He also stated he hopes that my hubby will be in a long and deeper remission.

[CoachVera55]

That is wonderful news, congratulations 🎉🎉How long was he on this combination therapy so far & how well is he tolerating it??? Also did you start here after how long of a W&W period???

[spi3 in reply to CoachVera55]

My hubby got seriously sick in Dec 2021 (at my mom's funeral and after he had his 4th COVID shot - I think this brought on his severe CLL) - we didn't find out what was wrong till mid-feb - they referred us to Dana-Farber who immediately put my hubby in a study 2 March 2022 starting with Acalabrutinib. Then, the next cycle, my hubby started obinutuzumab IVs, and last June 2021 (father's day), he started with venetoclax. He was instructed to drink 3 liters of water a day. He has no side effects. I call his Acalabrutinib and Venetoclax his Angel warriors killing his CLL. I'm praying for the same for everyone who takes immunotherapy treatments.

[Mystic75]

That's great news!

[spi3 in reply to Mystic75]

Ty - prayers truly work

[craterlake in reply to spi3]

AMEN !!! thanks for the wonderful report ...😊 blessings to you both ... james

[spi3 in reply to Mystic75]

Ty and I'm wishing the same for you too

[spi3]

Ty

[kitchengardener2]

How good read this. It certainly is encouraging for us all. My consultant told me that I could consider myself in partial remission. I take Acalabrutinib but she said if I stop then it is likely that my white cells will increase again. I feel really well, in fact I am thankful that I haven't actually felt ill ever, I just developed raised lymph nodes in my neck. God's blessings to you both. x

[spi3 in reply to kitchengardener2]

I'm so glad that you too are handling the acalabrutinib very well - they too are your warrior Angels - ty for your kind words and praying for you too

[Stamphappy]

So happy for both of you!

[spi3 in reply to Stamphappy]

Ty

[Catnap7]

Yay so happy for you! My Angel Warriors were Ibrutinib and Venetoclax I did do2yrs on this combo and got total UMRD one year in ..it was a two year trial and I stayed on it My trial ended 2 years plus 6 months ago Yesterday my doctor said my blood work was totally BORING as I’m sure yours is also Love BORING CONGRATULATIONS CATNAP7 🐈🐈

[spi3 in reply to Catnap7]

Awesome and right back at you! I never thought I would say this but "boring" is the place to be! So happy 😊 for you too - praying for you too for a long remission

[SKINOW]

Are you in a study? how did you get A and V

[spi3 in reply to SKINOW]

Yes we are at Dana-Farber in Boston

[SeymourB]

spi3 -

It's so heartening to hear these results!

Will there be another BMB at the very end?

Are they doing ClonoSEQ for MRD?

=seymour=

[spi3 in reply to SeymourB]

He's in a study- tons of tests and yes BMBs - they numbed the area in his back- and he did fine - he is negative MRD - taking meds to obtain a deeper remission for a long time

[SeymourB in reply to spi3]

spi3 -

I'm in a trial, too - at M.D. Anderson - Pirtobrutinib, Obinutuzumab, and Venetoclax. I'm getting MRD testing via both Flow Cytometry and ClonoSEQ at end of Cycle 4, 7, and 9, which is the end of the trial for those who achieve uMRD. If not, it goes on through Cycle 13.

=seymour=

[spi3 in reply to SeymourB]

Yes and hoping you too are so successful