Experiences with

Acalabrutinib

1. https://cllsociety.org/2025/01/amplify-trial-acalabrutinib-plus-venetoclax-for-cll/?form=MG0AV3 Prompt: That reference is also about plus venetoclax. Don't you know how to find acalabrutinib plus obinutuzumab without venetoclax? I apologize for the confusion earlier.

Ironically my haematologist started me on Acalabrutinib because she said it would help with the sweating, but I cannot see any improvement.

Hi there.Has anyone been on Acalabrutinib iam starting treatment today,1 tablet per day 100mg,then go for blood test end of month and see doctor to see if they can up it to 2 tablets per day. Thanks John.

Estimated 36-month overall survival was 94.1% with acalabrutinib–venetoclax, 87.7% with acalabrutinib–venetoclax–obinutuzumab, and 85.9% with chemoimmunotherapy.

can anyone help with night sweats on acalabrutinib?

https://cllsociety.org/2024/12/acalabrutinib-and-obinutuzumab-for-frontline-cll-treatment/

I’m on my 3rd month of Acalabrutinib and I must say I’m doing very well. I solved my headaches with iced coffee. Have a few aches in my legs. And a bit of inflammation in my nose. But my white blood cells are coming down and my heamaglobin is rising. So I must say I’m pleased with the result.

Hi I’ve been on Acalabrutinib for over two months now but feeling that my skin is getting a bit itchy like a heat rash. Can anyone suggest what I can put on it.

I’m taking Acalabrutinib with an antibiotic . I can’t understand that if I was to have infusion and a tablet I would only be on it for 7 months. But the same med in tablet form I am in it for life. Confused

A few days ago I read on here about people who are on Acalabrutinib are suffering with muscle and joint pain. My question is - did you stop taking the tablets or reduce the dose or continue to suffer with the pain? I haven't yet discussed this with Dr's so looking fir advise. Thanks.

I have been on acalabrutinib for almost two years and I am beginning to think I could be the poster child for side effects. My hair is very brittle and breaking off and my nails seem to be disintegrating. They split down the middle and then peel in layers.

Being a CLL patient and on Acalabrutinib is it best to stay away from people who are in contact with chickenpox?? My neighbour's grandchild who is 2 has it and so far i am avoiding contact with them as they look after her occassionally.

I just started my treatment about a week and a half ago. So far doing great. Very minor diarrhea one day and several minor headaches. My question is about drug storage. If you go to calquence dot com it says to store at 66 to 77 degrees f. What do you do if you go on a multiple day trip and everything

He received treatment in the UK STELLAR trial which adds Acalabrutinib to the usual R-CHOP chemotherapy. He's had a spectacular response and his story is here http://digitaleditions.telegraph.co.uk/data/1838/reader/reader.html?social#!

At the end of March I will finish taking 2 years of Acalabrutinib & Venetoclax under the Majic trail. During this time my adverse effects have been minimal and all my blood counts are reasobale and I feel great.

Another doctor is advocating for acalabrutinib plus antibody drip (rituximab) 375mg 1 dose every 28 days for 6 months.

In the meantime, he halved the acalabrutinib dose, but the symptoms have persisted. We have another appointment on Wednesday next week. My husband took the opportunity to get his bloods done on Friday so we have the results ready for the appointment.

/efficacy-and-safety-of-new%E2%80%91generation-btkis-primarily-acalabrutinib-and-zanubrutinib-in-cll-sll-a-systematic-review-and-meta%E2%80%91analysis[/i] [i]Largest real world study of and ibrutinib over 3 years, shows acalabrutinib has improved discontinuation rates[/i] [i]https

Now I’m on Acalabrutinib will I have to stop taking it before the op and then after for a week or so, any experience would be appreciated, thanks Will

Have had a runny nose for months and can only attribute this to either CLL- I am in remission- or continuous taking of Acalabrutinib (Calquence). Anyone have same experience?