Experiences with

Acalabrutinib

I am wondering if anyone has enlarged liver on acalabrutinib. I am on acalabrutinib since September 1st. My blood tests are much improved, but I feel now more pressure on the right side than the left side. Can acalabrutinib effect liver? My spleen decreased only slightly from 21 cm to 17cm.

Is anybody tested positive for Covid or covid antibodies being under Ibrutinib or acalabrutinib?

My husband has been on Acalabrutinib for 3 months but he has developed a few days ago an ear infecion requiring antibiotics. Does Acalabrutinib also increses the number and function of T cells the way ibrutinib does ? https://pubmed.ncbi.nlm.nih.gov/28714866/

Hi everyone As of November 25 , Acalabrutinib has been approved as a mono therapy for second line treatment in France for patients not doing well on Ibrutinib.

I wonder if anybody under ibrutinib or acalabrutinib treatment was infected and can describe how she/he survive. Thanks.

CLL since 2012 ( Ibrutinib 5 years , Gayzva 6 months , Acalabrutinib 2 years ) now bladder cancer , high grade , no wall penetration .... advised to take BCG for 6 weeks every 3 months for a year ... anyone shed light on what I can physically expect from the BCG ?

[i]First-line acalabrutinib plus obinutuzumab prolongs progression-free survival (PFS) compared to ibrutinib-obinutuzumab and venetoclax-obinutuzumab for patients with chronic lymphocytic leukemia (CLL), according to a study published in Clinical Lymphoma, Myeloma, & Leukemia (2020 Oct 29;S2152-2650(

Acalabrutinib keeps my CLL in check but gives me neutropenia. One strategy would be to cut the usual dose in half to 100 mg/day. Does anyone have experience with this dose? Is it possible that a dose that low could be effective?

I have a great report on how well Acalabrutinib is working. Start date for Acalabrutinib treatment was May 28 and today on October 28 (5 months later) I had a CT Scan and there has been a significant interval positive response to the treatment. Very happy!!!

7 weeks on acalabrutinib , headaches stopped after couple of days, but bloating and constipation continues ... any advice? Thank you, B

So, three weeks on Acalabrutinib and a visit to the haematologist. Results are looking good. After an initial rise, WBC is now on the way down. Platelets are up, as is haemoglobin. The spleen, which at the start of treatment would have won prizes at the county fair, can now not be felt.

I’m 55 and on my fourth line of treatment in 4 years: BR, Ibrutinib, Venetoclax, Acalabrutinib. And it looks like I’ll need a fifth soon. The acalabrutinib keeps the CLL in check but gives me neutropenia. Stopping acalacbrutinib for a week raised my ANC from 0.6 to 2.0.

https://www.clinicaloptions.com/infectious-disease/programs/covid-and-cll/faq-module/faq/page-1

I am difficulty with side effects of acalabrutinib, I am experiencing extreme fatigue and feel miserable. I have not read of anyone having to discontinue this drug due to side effects. Has anyone been on a lower than recommended dose?

Multiple treatments, now on acalabrutinib with good results. Some headaches and dizziness are the side effects. My problem has been leg cramps for years, now becoming more intense and problematic at night or when reclining. Not an issue while upright during the day.

I am currently taking Zofran before taking the Acalabrutinib and it works fine.

My husband had been on acalabrutinib for a few months. His IgG level has dropped from 7.4 ( low normal ) to 6.4 ( low ). His ALC has risen significantly but it's just starting to come down.

I think I read somewhere that this is also sometimes combined with ibrutinib or acalabrutinib?

Hi, Please everyone who is on ibrutinib or Acalabrutinib and who has developed allergy reaction to sun or just have normal tan please respond. Thanks, Mik

Hi, I’ve just been told that I will be put on acalabrutinib ....this will be the first treatment i have received as up until now I have been on watch and wait. If I’m honest I’m quite scarred of this new drug. How have others got on using acalabrutinib as a first line treatment? Thankyou x