Experiences with

Venetoclax

Anyone have treatment similar to this opposed to starting venetoclax on cycle 2 of obinutuzumab?

I had to stay in the hospital en started wit venetoclax and rituximab. I did very well on that for 2 years. they were the best from my CLL journey. 2 months ago I had to stop with venetoclax because the 24 months were passed. After 3 weeks I already felt swollen lymph nodes on my neck.

Dear all, has anyone been taking venetoclax and gotten a kind of persistent expectoration and sometimes a cough, especially at night? I still haven't figured out if it's related to the venetoclax or the cortisone I'm taking because of my kidneys. Thank you and kind regards.

After years with Venetoclax I now have inflammatory myositis Is there any connection known?

I take venetoclax for CLL. is it ok to take ibruprofin to reduce hip paqin?

I wonder if any of you on the VR treatment experienced itchy rashes on arms and legs?

My Venetoclax dose has been changed a number of times due to counts. Last few weeks have been 300mg and blood has been pretty normal except for platelets which have often been low but are now 88 - with everything else pretty much in line.

I have Covid, and wondered if I should still take my Venetoclax

Originally it was Venetoclax plus obinutuzumab. What is the difference, we have an appointment on the 18th to discuss but I just want to be clear. Mum has been doing well but suddenly her spleen has slightly enlarged and her hemoglobin has dropped. She is slightly anemic.

She is starting Venetoclax and immunotherapy this week and I was just checking to see if anyone had experience with this? TIA

Ramping up Venetoclax again to treat CLL. Specialist dr mentioned maybe try N-plate (other trombopotein) if thrombocytes start to fall again. Has anyone tried or heard of anyone with CLL using this? Any other suggestions?

Had FCR, Ibrutinib, and Venetoclax. I am on Venetoclax now for 18 months after 6 times of V+O. A year ago I lost my taste sense and everything tastes metallic,but the worse is a burning tongue sensation. Does it have any connetion to CLL or Venetoclax ?Gidi

[/u] I've looked at some results using ibrutinib and venetoclax, and venetoclax seems to very quickly reduce lymphocytic populations, even enough so it is dangerous, TLS, tumor lysis syndrome. So just as an example, I was thinking 20mg of venetoclax, the lowest starting dose, for 2 weeks.

We aimed to determine the incidence of and risk factors for TLS among patients with CLL/small lymphocytic lymphoma (SLL) who received treatment with venetoclax at our institution from 1/1/2016 to 12/31/2020. We included 616 venetoclax escalations among 136 pts with CLL.

Fourth line of treatment Venetoclax and Rituximab. 6 rounds of Rituximab commenced Feb 2024, and Venetoclax commenced April 24.

Zanubrutinib given for 8-12 weeks prior I would think to lessen the chance of TLS, and there were 0 reports of TLS, so seems like a good strategy 1) 100% ORR 2) 100% PFS 3) 10x the potency over venetoclax 4) 4 hour half-life -- this is a very short half life compared to 26 hours of venetoclax.

A Young Mom Confronts “Skyrocketing White Blood Cell Counts” https://www.patientpower.info/video/chronic-lymphocytic-leukemia/a-young-mom-confronts-skyrocketing-white-blood-cell-counts Kylie's blog about her + obinutuzumab trial https://www.courageloveandlegacy.com/

Started the Venetoclax 20mg all good , had an Infusion and 50mg Venetoclax, on Tuesday all good no issues. Next week will be 100mg then a week of 200mg and finally a week of 400mg. I have been going to the Ambulatory Care Unit at the Churchill Oxford.

From the limited data available in this study, patients with prior venetoclax exposure for CLL had lower likelihood of achieving CR than those who were venetoclax naïve (13% vs 40%). Survival outcomes remained poor overall.

She had stopped taking venetoclax since Sunday. They are giving her antibiotics but her blood counts are out of whack. Rbc are all low and her wbc is slightly high. So I have a couple of questions. Her doctor said to immediately stop the venetoclax (which she did before he told us).