ASH 2022 | Key highlights in CLL: clinical trial updates & the role of combination therapies and novel BTKis
Lindsey Roeker and Matthew Davids • 10 Dec 2022
vjhemonc.com/video/m1hovnhu...
The treatment landscape of chronic lymphocytic leukemia (CLL) is constantly evolving, with novel Bruton’s tyrosine kinase (BTK) inhibitors transforming the field. In this discussion, Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, and Lindsey Roeker, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discuss key highlights in CLL from the 2022 ASH Annual Meeting. The experts comment on the role of doublet therapies with ibrutinib and venetoclax, and discuss long-term follow-up data from several clinical trials, including CAPTIVATE (NCT02910583), ALPINE (NCT03734016), and GLOW (NCT03462719). Following this, Dr Davids and Dr Roeker highlight the growing role of triplet therapies, and further discuss the impact of novel BTK inhibitors such as zanubrutinib. This discussion took place at the 64th ASH Annual Meeting and Exposition congress held in New Orleans, LA.
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