Can someone tell me how I could get more information about Quest total spike antibody test 39820 besides the Information contained in this education.questdiagnostics.... link.
I am trying to understand what the possible range of values for this thest. My test result was >2500.0 H which I believe is the highest end of the scale.
Does anyone know how to get more information from Quest or have any knowledge about the possible range of values for the test.
I know that > 0.8 is a positive but what I want to know is where does my result fit into the possible range of values. I think >2500.H is at the high end of the scale but need some confirmation.
It was a real struggle with my Doctor to get this test and I do not think I will get much assistance in understanding the results.
Thanks for any information anyone can provide!
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CoopersHuman
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CH, The Quest Covid Total Spike Antibody Test 39820 that you have results from is the Cobas® Elecsys Anti-SARS-CoV-2 S (spike) test, according to the information on the Quest site. Please take a look at reference 8.
8. Cobas® Elecsys Anti-SARS-CoV-2 S (spike). Instructions for use. Roche Diagnostics Inc; 2021. Accessed April 7, 2021. fda.gov/media/144037/download
If that is indeed the case, since LabCorp also uses the Cobas® Elecsys Anti-SARS-CoV-2 S (spike) test the figures that I posted a while back will give you an idea of where your >2500 stands relative to others who have been tested with that assay.
Your level of antibodies is higher that the upper limit of the test as it was administered to you. If your serum had been diluted 1 to 10 again, you would be able to tell how many more antibodies you produced.
Well, unfortunately, researchers have not yet determined what a protective level of antibodies is.
This is from the link you provided:
“Positive results may also occur after a COVID-19 vaccination, but the clinical significance is not yet known. 1,11-13 At this time, there are no FDA authorized tests for individuals that have received a COVID-19 vaccination and the performance characteristics of the authorized antibody tests have not been established for those individuals.Since much is still not known about the body’s immune response to this virus, this test result cannot be used to indicate a level of immunity or rule out the chance of reinfection.”,
This topic did come up during the CDC panel this week, but it was reiterated that they still do not have a “protective correlate.” In other words, they still don’t know what level of antibodies is needed for one to be considered protected from the virus.
Bottom line: regardless of your result numbers, they cannot currently be used to determine your immunity or how protected you are against the virus. This goes for healthy and immuno compromised alike.
A few other asides -
It’s also my understanding that the antibody results may drop with time. So antibody levels in June may be higher than what they are in October or December. Just something to be aware of. Variables can include age, vaccine type, disease, etc
There are also other parts of the immune system being looked at, such as t-cells, to see if we may garner some protection from them beyond the b-cells.
I did come across a currently non-peer reviewed study in mice that found T-cells were not protective, but I’m keeping an eye on that to see if it becomes peer reviewed.
I will include a link to the pre-print also, but with the stressed caveat that it’s a pre-print which hasn’t been peered reviewed. I’m a lay person here, and unsure if there will still be peer review or how the process works.
I have asked an research asst friend who is in this area for his thoughts.
At the same time I have an infectious disease RN friend who sends me tweets she feels shows t-cells are going to help.
With the internet, there’s so so much info, but it can be daunting to sort through and sometimes difficult to interpret. This is for any topic, not just t-cells or what level of antibodies is protective, and so on.
I don’t mean to add to that, but at the same time, we’ve all been rooting for t-cells to be what gives more protection from the virus. Until we have more data, we just don’t know yet. We can all hope, but if it should turn out that b-cells are the heavy lifters, I know how disappointing that would be across the board.
In addition to needing more data on everything, there is also research on and development of therapeutics, especially with a view towards those who have attenuated or absent immune responses.
Pin57, I've looked at the testingforall web site and have a couple of questions. Is the Roche Anti-SARS-CoV-2 (S) test different from the Roche Elecsys Anti-SARS-CoV-2 S (spike) test? The Elecsys Anti-SARS-CoV-2 S (spike) test doesn't claim to measure neutralizing antibodies, something that requires a different more difficult and expensive test.
Testingfor all claims that their test measures neutralizing antibodies, which is very hard to believe since it is a much more difficult test to run.
"Those that receive a result of > 2,500 have a neutralising antibody response of at least 2,500 U/mL indicating a very high antibody level."
A quote from the Roche site: "Antibody tests by nature are not designed to distinguish between neutralizing and non-neutralizing antibodies" diagnostics.roche.com/us/en...
Testingforall advertises that their test measures" immunity". Even Roche doesn't claim that!
I've bookmarked the site and will be interested to see what the numbers look like when they have more data.
Great questions G-G. You are way more informed on this very topic than I for sure and I cannot answer your questions. Like you, I will follow this and will try to learn more about this topic as well.
This is a great result. Although no-one can say for sure that it's protective, what can be said is that you are excellent at producing protective antibodies and that is a very good thing and predictive of protection after other vaccines. Brian Koffman CLLSociety.org
Hi, welcome to the group, Can you share a little more about your CLL and treatment history. It may help others as this is an exceptional result for someone who has CLL
Dang, I think I am in the wrong group. I do not have CLL. I am autoimmune with PSA. I have had a hard time getting information about how to interpret the results of my Antibody test and this group has more information than I have found anywhere else. Thanks for the replies and useful information.
When I went to the LLS group to ask about my test results (mine were also >2500.0) and a doctor responded that originally they were testing CLL patient out to 250.00 - then there were some test being run out to 2500.0 — and he stated that my test must be one run out to 2500 and I had good results but could not give me an exact as the test would have to be run out farther to have more specifics as to my test. I’m assuming this is the same for you. I know they don’t know 100% how antibodies are effecting full outcomes of Covid but I recently read an article that showed in the US only 0.8% of the recent deaths were from people vax’d and out of 850,000 new cases only 1200 were vax’d — so I’m hoping that studies are done soon showing what type of affect the antibodies make and if those that don’t produce are still showing protection (possibly from Tcell?) or if there will be a possible booster for those as well?
Replies are now being turned off as poster does not have CLL and the antibody results gained may not be representative in the CLL population. However, excellent and informative responses given by responders on the subject generally.
Newdawn
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