Experiences with

Fludarabine, cyclophosphamide and rituximab (FCR)

Four years after FCR or chemo treatment, and three and a half years after Gyzava or immunotherapy now I am taking Brukinsa. Does anybody have a similar experience? How long can Brukinsa keep me going? Thank you

Hi I had 3 rounds FCR in Winter 2018 stopped for Neutropenia. My doc did NO testing for mrd or even flow. Ignorance was bliss til release 2 years later. Started V + O March 2023 for R/R.

In the ten yrs he's had CLL He's had FCR, IBRUTINIB AND VENTACLAX. Thanks

After diagnosed with CLL, unmutated, Trisomie 12, cd38 neg, Zap 70 30%, I received FCR 6 cycles. Afterwards 9 years therapy free in 10/2022 got a DLBCL and was treated with R CHOP 14 6 times. Suspicion of Richters because of CLL.

My husband was diagnosed in 2010 at the age of 40. 2013 he had FCR. 11 years later, he is in week 5 of venteclax, Rituximab to follow next month. Swollen lymph nodes have disappeared.

An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999, Sustained remissions in CLL after frontline treatment with very-long-term follow-up, reports ~47% of patients with mutated IGHV

I'd also like to know which form of treatment would be preferable: FCR, oral targeted medicines, FCR, or anything else? I am asking you to share your experiences and information, which I will utilize to discuss with the physician. I wish you all the best. God bless you all.

Had FCR, Ibrutinib, and Venetoclax. I am on Venetoclax now for 18 months after 6 times of V+O. A year ago I lost my taste sense and everything tastes metallic,but the worse is a burning tongue sensation. Does it have any connetion to CLL or Venetoclax ?Gidi

Treatment with FCR is imminent but only after a severe skin infection has cleared up. Dermatologist took 2 biopsies which the Pathologist reported skin infection/rash was Hypersensitive Dermatitis. I had an IV when I had a CT scan & the thought is this could be a cause.

As you may know, my husband was diagnosed with CLL back in 2013, treated with six cycles of FCR, and achieved a "full response with incomplete recovery of the bone marrow." He had severe complications after treatment, but the CLL never recurred.

I’ve had three courses of chemo over the years: FCR, twice and not sure what the third dose was (CVR?) though it didn’t work anyway. 4 yrs of Ibrutinib then 2 yrs on Venetoclex which finished in March this year. Had a bone marrow which had markers (3) of Mylodysplasia (?)

[/u] I had 3 rounds of FCR in 2018 stopped because of profound neutropenia. I relapsed exactly 2 years later and though I did not start Tx until the 5 year point in 2023, would have gladly started it 9 months ealier due to B symptoms.

In 2012 I got FCR for six rounds. After that I was stuffy and it occurred that I had heart failure because of the chemo therapy. It took me years to recover from that. In 2017 I started with Ibrutinib and stayed on that for 4 years.

Starting in 2019 I've had FCR, Nov 2022 splenomegaly and other leukemia symptoms so January 2023 I started on Ibrutinib, giving partial remission but with colitis side effects. Sept 2023 Zanbrutinib but with even worse colitis (diarrhrea). I chose to go back to Ibrutinib.

UK based, CLL for 15 years, Treatments: FC, FCR, Ibrutinib, Venetoclax for 2.5 years, 6 month break now back on Venetoclax

I am on months 15 of V+ O Relapsed 2 years after 3 months FCR stopped due to profound neutropenia for nine months.

Reminds me of going through FCR! This is day four after the second vaccine and I’ve finally started to improve, but still pressure in my head, wobbly legs and tiredness. ☹️

Had FCR as first line treatment. Was on remission for about a year before relapse. Currently on Ibrutinib since 5 months now. I had shingles on my left leg about 3 months ago. Was treated with Acyclovir.

Technically, I consider myself partially treated rather than relapsed or refractory, because I only received three of the six cycles of FCR due to profound neutropenia. I just learned from my oncologist that I can’t get the UMRD6 test because we had no bone marrow biopsy done before treatment.

My husband has CLL and finished FCR in April 2019. Due to low platelets, enlarged spleen and ALC doubling he needs to start his next treatment even though he feels wellV&R is the treatment starting on 15th May.