Experiences with

Obinutuzumab

Anyone have treatment similar to this opposed to starting venetoclax on cycle 2 of obinutuzumab?

Hi All had my two first infusions on Tuesday and Wednesday no issues at all despite some posts I have seen. Steroids did cause sleeping issues later but I did enjoy the pre meds. Blood results showed from Tuesday infusion showed slightly raised 222k to 232k. With get Bloods redone next Tuesday before

But you don't realise how slowly Cll changes things well I didn't anyway, so you go along thinking things are normal but there not once I had the 100mg sample of Obinutuzumab I felt different and after the rest on the 2nd day I was energised felt good but that might just be me.

A Young Mom Confronts “Skyrocketing White Blood Cell Counts” https://www.patientpower.info/video/chronic-lymphocytic-leukemia/a-young-mom-confronts-skyrocketing-white-blood-cell-counts Kylie's blog about her venetoclax + trial https://www.courageloveandlegacy.com/

I’m on the Pirtobrutinib , Venetoclax, Obinutuzumab trial for Richters. The rash looks like a salmon color bruise. It doesn’t hurt, itch, or change in size. There is no other rash on my body. It’s a curiosity that I wonder if anyone else has experienced?

Originally it was Venetoclax plus obinutuzumab. What is the difference, we have an appointment on the 18th to discuss but I just want to be clear. Mum has been doing well but suddenly her spleen has slightly enlarged and her hemoglobin has dropped. She is slightly anemic.

i started OV treatment in April and have finished the cycles of Obinutuzumab. My Venetoclax dose has been changed a number of times due to counts.

🙄 He has given me notes on my treatment - Obinutuzumab and Venetoclax. Two days in hospital and and at least 3 in outpatients, to start off with. Oh and he's said go on your holiday now, and come back in 6 weeks. That's all. Love and blessings to everyone!

Hi All Started this on the 9th. 100ml then remainder on the 10th July. No reactions at all bloods taken on the 9th after trial infusion showed slight increase from 222k to 232k. remainder on the 10th all ok had a blood test yesterday. WBC was 232k now on the 15th July 3900 Its amazing, unbelievable

Obinutuzumab and Venetoclax 12 x 28 days Cycles. I will be at the Churchill in Oxford even though I live in Northants.

Atezolizumab, venetoclax, and obinutuzumab combination in Richter transformation diffuse large B-cell lymphoma (MOLTO): A multicentre, single-arm, phase 2 trial. [i]The Lancet. Oncology[/i], S1470-2045(24)00396-6.

I have finished obinutuzumab and am now just on venetoclax.My hair has been unaffected by these treatments. I would like to have good quality highlights and lowlights - is this OK?

I’m in the Pirtobrutinib, Venetoclax, Obinutuzumab trial that started May of this year. I got a PET/CT scan in late April before the trial began. When I met with my Doc after the end of Cycle 4 for the first results of the PET/CT to determine if trial was working, he was ecstatic.

abstract in advance of the European Hematological Association Congress June 13-16, 2024: https://library.ehaweb.org/eha/2024/eha2024-congress/422268/nitin.jain.combined.pirtobrutinib.venetoclax.and.obinutuzumab.in.first-line.html [i]Abstract: S164 Title: COMBINED PIRTOBRUTINIB, VENETOCLAX, AND

You can read more about obinutuzumab and this decision on our website: https://lupusuk.org.uk/obinutuzumab-not-recommended-for-funding-by-nhs-england/

My hubby's treatment is venetoclax and acalabrutinib (he previously had obinutuzumab too). He is also taking sulfameth trimeth (for ammonia) and valacyclivor (for shingles) dropped from 1200 to 800 mg a day.

I was told my immune system would return one year after the completion of Obinutuzumab infusions and those ended in September of 2021. Has anyone had the same issue? Thx.

I’m now in mid Cycle 3 of the Venetoclax, Pirtobrutinib, & Obinutuzumab trial. I’m tolerating it very well. Almost all my blood work is now in range with platelets low at 116. I get another PET/CT and bone marrow in 2 weeks to determine how it’s working.

for patients with chronic lymphocytic leukemia https://www.healio.com/news/hematology-oncology/20240828/measurable-residual-disease-status-predicts-pfs-for-patients-with-chronic-lymphocytic-leukemia [i]Rios-Olais and colleagues used data from prospective trials that evaluated targeted agents or obinutuzumab

My doctor suggested a combination of obinutuzumab and venetoclax or zanubrutinib. I'm 72 years old and otherwise in good health. No symptoms yet but increasing WBC I'm wondering what the pros and cons of each are. My doctor likes the infusions because after a year you're done.