Experiences with

Obinutuzumab

. ---- At this point, I gave up, because acalabrutinib plus in ELEVATE-TN was not fixed duration, as can be seen in protocol listed at: https://clinicaltrials.gov/study/NCT02475681 "[i]Experimental: Arm B - Acalabrutinib in Combination with Obinutuzumab[/i] [i]Obinutuzumab IV

obinutuzumab would be alive without disease getting worse 4 years after starting treatment compared with only 25% of patients who had the usual chemoimmunotherapy option of obinutuzumab plus chlorambucil.

https://cllsociety.org/2024/12/acalabrutinib-and-obinutuzumab-for-frontline-cll-treatment/

My treatment plan is four infusions of obinutuzumab during the first month, then one each for 5 more months. I'll start venetoclax on day 22 and continue to take it for a year.

Started obinutuzumab, atezoluzumab, venetoclax in July. Mixed results. Will have another pet July. May enter trial or go Cart T route. Dual care at VA and private onc. Obin knocks platelets down so I discontinue venetoclax for a week after each infusion.

median OS was not reached in any treatment arm and was considerably longer in patients treated with Acalabrutinib-Obinutuzumab versus Obinutuzumab-Chlorambucil combination.¹⁸ However, patients in the Acalabrutinib-Obinutuzumab arm experienced more frequently grade ≥3 adverse

Anyone have treatment similar to this opposed to starting venetoclax on cycle 2 of obinutuzumab?

This will start with obinutuzumab with venetoclax to be added in 3 weeks. Are these the standard drugs used? I’ve been due to start treatment previously (2 years ago) and the drugs were different then. Appreciate things move quickly. Thanks all Alan

I received six months of obinutuzumab And 400 mg Venetoclax. My oncologist did a bone marrow biopsy and a CT scan. The results of the CT scan were all normal lymph nodes and the results of the bone marrow biopsy were clear of any disease.

In February of this year (2025), the NCCN added AV (Acalabrutinib/Calquence plus Venetoclax) and AVO (AV plus Obinutuzumab/Gazva) for first line treatment to its Clinical Guidelines for CLL, page CSLL-D, despite the fact that these 2 treatment regimes are not yet approved by the FDA or any other regulatory

As I have been fighting CLL for almost 5 years and failed treatments of Acalabrutinib, Venetoclax, Pirtobrutinib and Obinutuzumab, this is apparently the best way currently to treat this wily disease. I hope so.

Originally it was Venetoclax plus obinutuzumab. What is the difference, we have an appointment on the 18th to discuss but I just want to be clear. Mum has been doing well but suddenly her spleen has slightly enlarged and her hemoglobin has dropped. She is slightly anemic.

I’m on the Pirtobrutinib , Venetoclax, Obinutuzumab trial for Richters. The rash looks like a salmon color bruise. It doesn’t hurt, itch, or change in size. There is no other rash on my body. It’s a curiosity that I wonder if anyone else has experienced?

Matthew Davids, MD, MMSC, presented findings that a time-limited regimen of acalabrutinib, venetoclax, and obinutuzumab (AVO), guided by measurable residual disease (MRD), showed positive results.

With the obinutuzumab regimen, however, OS was significantly improved only after censoring for COVID-19 deaths, said Brown.

But you don't realise how slowly Cll changes things well I didn't anyway, so you go along thinking things are normal but there not once I had the 100mg sample of Obinutuzumab I felt different and after the rest on the 2nd day I was energised felt good but that might just be me.

i started OV treatment in April and have finished the cycles of Obinutuzumab. My Venetoclax dose has been changed a number of times due to counts.

🙄 He has given me notes on my treatment - Obinutuzumab and Venetoclax. Two days in hospital and and at least 3 in outpatients, to start off with. Oh and he's said go on your holiday now, and come back in 6 weeks. That's all. Love and blessings to everyone!

Hi All had my two first infusions on Tuesday and Wednesday no issues at all despite some posts I have seen. Steroids did cause sleeping issues later but I did enjoy the pre meds. Blood results showed from Tuesday infusion showed slightly raised 222k to 232k. With get Bloods redone next Tuesday before

A Young Mom Confronts “Skyrocketing White Blood Cell Counts” https://www.patientpower.info/video/chronic-lymphocytic-leukemia/a-young-mom-confronts-skyrocketing-white-blood-cell-counts Kylie's blog about her venetoclax + trial https://www.courageloveandlegacy.com/