Experiences with

Fludarabine

Those older chemoimmunotherapy treatments, typically Bendamustine + Rituximab (BR) or Fludarabine + Cyclophosphamide + Rituximab (FCR), selected for tougher to treat sub-clones, which they cause through inducing DNA damage that will hopefully trigger apoptosis [u]if[/u] the TP53 gene isn't mutated or

An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999, Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up, reports ~47% of patients with mutated IGHV

After diagnosed with CLL, unmutated, Trisomie 12, cd38 neg, Zap 70 30%, I received FCR 6 cycles. Afterwards 9 years therapy free in 10/2022 got a DLBCL and was treated with R CHOP 14 6 times. Suspicion of Richters because of CLL. But clonal checks in special LAB showed no relationship with CLL and PET

Four years after FCR or chemo treatment, and three and a half years after Gyzava or immunotherapy now I am taking Brukinsa. Does anybody have a similar experience? How long can Brukinsa keep me going? Thank you

After 5 of 6 of fludarabine cyclophosphamide rituximab I went into semi remission and now after many hospitalizations with infection have IVIG once a month that works quite well at keeping me out of the hospital.

Hi everyone , I am so glad with this site. My name is Anja, 67 years old , and I live in the Netherlands. I was diagnosed with CLL in september 2010. In 2012 I got FCR for six rounds. After that I was stuffy and it occurred that I had heart failure because of the chemo therapy. It took me years

I was diagnosed with CLL in 2002 & been on wait & watch until recently. Treatment with FCR is imminent but only after a severe skin infection has cleared up. Dermatologist took 2 biopsies which the Pathologist reported skin infection/rash was Hypersensitive Dermatitis. I had an IV when I had a CT

Hi I had 3 rounds FCR in Winter 2018 stopped for Neutropenia. My doc did NO testing for mrd or even flow. Ignorance was bliss til release 2 years later. Started V + O March 2023 for R/R. At one year, 3/24 was umrd 4 on PB and 4/10,000 on BM. 5 months later or month 18 of Ven mrd increased

Hi. I live in Adelaide, Australia and I'm anxious about possible treatments now. I was diagnosed at the end of 2016. Starting in 2019 I've had FCR, Nov 2022 splenomegaly and other leukemia symptoms so January 2023 I started on Ibrutinib, giving partial remission but with colitis side effects. Sept

I now have a swollen lymph node near my collarbone on my neck which is the size of a hard boiled egg and one under my armpit on the same side which is duck egg size. I’ve had three courses of chemo over the years: FCR, twice and not sure what the third dose was (CVR?) though it didn’t work anyway. 4

I know I'm preaching to the choir yet it's nice to have a listening understanding ear. Just had my 16th and 17th malignant skin cancer removed since receiving FCR in 2018 despite following all the recommendations My back pain that became radicular pain is due to some severe spinal stenosis and a large

Just wanted to know if anyone knew anything about Allograft. My husband has just finished 2 yrs on ventaclax, all blood's good, and we expected to just go away and go back for blood's until maybe time for a different treatment, but was told they would like us to have a chat to a specialist about allograft

Hi everyone. As you may know, my husband was diagnosed with CLL back in 2013, treated with six cycles of FCR, and achieved a "full response with incomplete recovery of the bone marrow." He had severe complications after treatment, but the CLL never recurred. In November 2023 he began to experience

Does anyone have any data or medical journal articles, addressing the contagious for either Pre symptomatic infections or individuals that have asymptomatic viral infections.. Also, in my home state of Utah in the USA, I have not been able to find any published data on the current incident or presence

I sent this to skyshark based on some info he posted but I was[u] hoping for the whole group to chime in.[/u] I had 3 rounds of FCR in 2018 stopped because of profound neutropenia. I relapsed exactly 2 years later and though I did not start Tx until the 5 year point in 2023, would have gladly started

The prognosis for bendamustine isn't as good as fludarabine - the likely effective period being 4 or 5 years as opposed to 15 years for fludarabine, but thats life. Overall, the post treatment fatigue and brain fog was a surprise and not a good one. But I wasn't in pain.

I was dx 10 years ago. Had FCR, Ibrutinib, and Venetoclax. I am on Venetoclax now for 18 months after 6 times of V+O. A year ago I lost my taste sense and everything tastes metallic,but the worse is a burning tongue sensation. Does it have any connetion to CLL or Venetoclax ?Gidi

As I previously stated, my wife was diagnosed with CLL in 2020. Her markers are 13q deletion, 12 trisomy, and TP53, with IGHV muted. She is still in W&W form. So far, I've learned via reading literature and numerous posts about lymphocyte doubling time, lactate dehydrogenase, and lymph nodes. Her lymphocyte

My husband has CLL and finished FCR in April 2019. Due to low platelets, enlarged spleen and ALC doubling he needs to start his next treatment even though he feels wellV&R is the treatment starting on 15th May. I have researched extensively including within this group, and am aware of the treatment

My husband was diagnosed in 2010 at the age of 40. 2013 he had FCR. 11 years later, he is in week 5 of venteclax, Rituximab to follow next month. Swollen lymph nodes have disappeared.