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CLL survival times ARE improving, thanks to BTK and BCL-2 inhibitors
Those older chemoimmunotherapy treatments, typically Bendamustine + Rituximab (BR) or
Fludarabine
+ Cyclophosphamide + Rituximab (FCR), selected for tougher to treat sub-clones, which they cause through inducing DNA damage that will hopefully trigger apoptosis [u]if[/u] the TP53 gene isn't mutated or
Those older chemoimmunotherapy treatments, typically Bendamustine + Rituximab (BR) or
Fludarabine
+ Cyclophosphamide + Rituximab (FCR), selected for tougher to treat sub-clones, which they cause through inducing DNA damage that will hopefully trigger apoptosis [u]if[/u] the TP53 gene isn't mutated or
AussieNeil
Administrator
in
CLL Support
19 days ago
My chemo experience
The prognosis for bendamustine isn't as good as
fludarabine
- the likely effective period being 4 or 5 years as opposed to 15 years for
fludarabine
, but thats life. Overall, the post treatment fatigue and brain fog was a surprise and not a good one. But I wasn't in pain.
The prognosis for bendamustine isn't as good as
fludarabine
- the likely effective period being 4 or 5 years as opposed to 15 years for
fludarabine
, but thats life. Overall, the post treatment fatigue and brain fog was a surprise and not a good one. But I wasn't in pain.
kiwiCanuck
in
CLL Support
1 year ago
lymphocytes/neutrophils
After 5 of 6 of
fludarabine
cyclophosphamide rituximab I went into semi remission and now after many hospitalizations with infection have IVIG once a month that works quite well at keeping me out of the hospital.
After 5 of 6 of
fludarabine
cyclophosphamide rituximab I went into semi remission and now after many hospitalizations with infection have IVIG once a month that works quite well at keeping me out of the hospital.
Kimsome
in
CLL Support
7 months ago
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POST 3 - CAR-T cell therapy
Lymphodepletion {chemotherapy} will also commence: Cyclophosphamide {D-6} also
Fludarabine
for four days {D-6 to D-3} followed by two days rest and then Day 0 {14th June} will be the exciting day that I receive the first small dose of the modified T-cells.
Lymphodepletion {chemotherapy} will also commence: Cyclophosphamide {D-6} also
Fludarabine
for four days {D-6 to D-3} followed by two days rest and then Day 0 {14th June} will be the exciting day that I receive the first small dose of the modified T-cells.
casanova
in
CLL Support
11 months ago
UK NICE Approves Ibrutinib +Venetoclax for First Line treatment for ALL Patients from today
[/i] [i]
A: During scoping consultation, a consultee highlighted an urgent need for access to novel treatments for younger, fitter patients with chronic lymphocytic leukaemia as currently only
, cyclophosphamide and rituximab (FCR) or venetoclax plus obinutuzumab via the Cancer Drugs
[/i] [i]
A: During scoping consultation, a consultee highlighted an urgent need for access to novel treatments for younger, fitter patients with chronic lymphocytic leukaemia as currently only
, cyclophosphamide and rituximab (FCR) or venetoclax plus obinutuzumab via the Cancer Drugs
Jm954
Administrator
in
CLL Support
1 year ago
Relative risk for secondary bone marrow cancer within 5 years after initial CLL chemoimmunotherapy treatment (typically BR or FCR)
In countries where targeted therapies ('brutinibs, venetoclax, obinutuzumab/rituximab) are now available, the remaining reason that FCR (
Fludarabine
+Cyclophosphamide+Rituximab) is still sometimes recommended for the treatment of CLL is that it can be curative* about 55% of the time - but [u]
only[
In countries where targeted therapies ('brutinibs, venetoclax, obinutuzumab/rituximab) are now available, the remaining reason that FCR (
Fludarabine
+Cyclophosphamide+Rituximab) is still sometimes recommended for the treatment of CLL is that it can be curative* about 55% of the time - but [u]
only[
AussieNeil
Administrator
in
CLL Support
9 months ago
Venetoclax for dummies
An example of an immunotherapy drug is rituximab, the "R" drug in FCR (the F drug in the combo is
fludarabine
, the C drug is cyclophosphamide). Rituximab binds to a protein on the surface of cancerous lymphocytes.
An example of an immunotherapy drug is rituximab, the "R" drug in FCR (the F drug in the combo is
fludarabine
, the C drug is cyclophosphamide). Rituximab binds to a protein on the surface of cancerous lymphocytes.
cajunjeff
in
CLL Support
10 months ago
Reply to issues with Spleen
Hi, I agree with most of these comments on here that the enlargement of your spleen is an indication perhaps that you are ready for some form of treatment, not removal. I had chemotherapy in 2020 and my spleen was massive. After a treatment cycle of FCR for 6 months and neutropenia sepsis for 10
Hi, I agree with most of these comments on here that the enlargement of your spleen is an indication perhaps that you are ready for some form of treatment, not removal. I had chemotherapy in 2020 and my spleen was massive. After a treatment cycle of FCR for 6 months and neutropenia sepsis for 10
Roseneath69
in
CLL Support
7 days ago
Recently started Acalabrutinib
Hi everyone, My father has recently started Acalabrutinib 5 days ago. He was diagnosed with CLL in 2007 and has received FCR (twice) and Benda-Ritux once. His CLL only went into partial remission on benda-ritux and has come back after one year since his last cycle of BR. I am worried regarding the
Hi everyone, My father has recently started Acalabrutinib 5 days ago. He was diagnosed with CLL in 2007 and has received FCR (twice) and Benda-Ritux once. His CLL only went into partial remission on benda-ritux and has come back after one year since his last cycle of BR. I am worried regarding the
Healthgiddy
in
CLL Support
13 days ago
uMRD 6
I have been living for the one year point on V plus O to get the clonal sequence uMRD6 bone marrow test done so I could decide if I wanted to continue with a Venetaclax. Technically, I consider myself partially treated rather than relapsed or refractory, because I only received three of the six cycles
I have been living for the one year point on V plus O to get the clonal sequence uMRD6 bone marrow test done so I could decide if I wanted to continue with a Venetaclax. Technically, I consider myself partially treated rather than relapsed or refractory, because I only received three of the six cycles
skipro
in
CLL Support
26 days ago
Wife getting MMR vaccine booster - isolate or not?
I'm an SLL patient, 55 years old, now about 2.5 years into remission after 6 FCR treatments. I just recovered from a recent (and thankfully mild) bout of shingles. My shingles was so mild that my GP wasn't convinced it actually was shingles! She had me tested for herpes zoster antibodies, and for good
I'm an SLL patient, 55 years old, now about 2.5 years into remission after 6 FCR treatments. I just recovered from a recent (and thankfully mild) bout of shingles. My shingles was so mild that my GP wasn't convinced it actually was shingles! She had me tested for herpes zoster antibodies, and for good
xpro3
in
CLL Support
1 month ago
Solutions needed to manage nerve pains ( Post herpetic neuralgia ) after shingles .
I was diagnosed of CLL in 2021. Had FCR as first line treatment. Was on remission for about a year before relapse. Currently on Ibrutinib since 5 months now. I had shingles on my left leg about 3 months ago. Was treated with Acyclovir. The sores and blisters have gone but the nerve pains( especially
I was diagnosed of CLL in 2021. Had FCR as first line treatment. Was on remission for about a year before relapse. Currently on Ibrutinib since 5 months now. I had shingles on my left leg about 3 months ago. Was treated with Acyclovir. The sores and blisters have gone but the nerve pains( especially
Oldscores1
in
CLL Support
2 months ago
Epithelial Haemangiendothelioma - has anyone else been diagnosed with this rare cancer please?
Hello, Having been diagnosed with CLL back in February 2002 (age 50) I was successfully treated with FCR from August 2009 to February 2010 and remain MRD negative as at present. Breast cancer followed in April 2016, then bowel cancer in September 2018. A five year surveillance period followed the
Hello, Having been diagnosed with CLL back in February 2002 (age 50) I was successfully treated with FCR from August 2009 to February 2010 and remain MRD negative as at present. Breast cancer followed in April 2016, then bowel cancer in September 2018. A five year surveillance period followed the
alipali
in
CLL Support
2 months ago
Shingrix side effects
just wondered what people’s experiences are with side effects after Shingrix? I had the first vaccine and was ill the next day with headaches, chills and feeling awful. However after the second vaccine the side effects have been worse, add in : headaches, unable to concentrate, weakness and wave upon
just wondered what people’s experiences are with side effects after Shingrix? I had the first vaccine and was ill the next day with headaches, chills and feeling awful. However after the second vaccine the side effects have been worse, add in : headaches, unable to concentrate, weakness and wave upon
Mandy56
in
CLL Support
2 months ago
splashsplash
UK based, CLL for 15 years, Treatments: FC, FCR, Ibrutinib, Venetoclax for 2.5 years, 6 month break now back on Venetoclax
UK based, CLL for 15 years, Treatments: FC, FCR, Ibrutinib, Venetoclax for 2.5 years, 6 month break now back on Venetoclax
splashsplash
in
CLL Support
4 months ago
Ibrutinib stopped working, what’s next
Morning all,a quick recap on journey so far, FCR treatment which kept things at bay for 14 months, then onto Ibrutinib for 6 years approximately, currently lymph nodes at 5cm , next treatment starts in January Rituximab and Ventoclax for 2 years, just wondering if there are any alternatives? Thanks all
Morning all,a quick recap on journey so far, FCR treatment which kept things at bay for 14 months, then onto Ibrutinib for 6 years approximately, currently lymph nodes at 5cm , next treatment starts in January Rituximab and Ventoclax for 2 years, just wondering if there are any alternatives? Thanks all
Stacky66
in
CLL Support
4 months ago
hu CAR-T 19 IL-18 4th Generation Clinical Trial 90 Day Check-up With All of My Favorite Tests
It's been a long time since I have received a MRD negative diagnosis, 13 years to be exact, after my FCR treatment. All of the other treatments didn't require a BMB to confirm a negative reading, I had a few remissions, but they were just on paper. My blood counts were good, and I felt fine, but a relapse
It's been a long time since I have received a MRD negative diagnosis, 13 years to be exact, after my FCR treatment. All of the other treatments didn't require a BMB to confirm a negative reading, I had a few remissions, but they were just on paper. My blood counts were good, and I felt fine, but a relapse
steve5441
in
CLL Support
4 months ago
Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease
From the New England Journal of Medicine 10th December 2023 [i]"The CLL treatment landscape has been transformed by targeted drugs. Continuous BTK inhibitor therapy has improved outcomes in patients with CLL. Fixed-duration venetoclax in combination with obinutuzumab or ibrutinib has also been shown
From the New England Journal of Medicine 10th December 2023 [i]"The CLL treatment landscape has been transformed by targeted drugs. Continuous BTK inhibitor therapy has improved outcomes in patients with CLL. Fixed-duration venetoclax in combination with obinutuzumab or ibrutinib has also been shown
Jm954
Administrator
in
CLL Support
4 months ago
Transformation of Richter's Transformation Treatment to combination targeted therapy - tislelizumab +zanubrutinib (ASH 2023)
Richter's Transformation treatments are typically fixed term R-CHOP*, or modifications of that chemoimmunity therapy. So it's encouraging to hear that [i]"In a phase 2 trial, anti-PD-1 inibitor tislelizumab + next gen BTK inhibitor zanubrutinib had an overall response rate of 58.3% in patients with Richter's
Richter's Transformation treatments are typically fixed term R-CHOP*, or modifications of that chemoimmunity therapy. So it's encouraging to hear that [i]"In a phase 2 trial, anti-PD-1 inibitor tislelizumab + next gen BTK inhibitor zanubrutinib had an overall response rate of 58.3% in patients with Richter's
AussieNeil
Administrator
in
CLL Support
4 months ago
R-CHOP Treatment
After FCR chemo 15 years ago and numerous oral medications since I am in chemo again. They tried a milder chemo to reduce my lymph nodes (they were huge). Some success, but not as much as I needed. So now I've had one round of R-CHOP. All that it has done for me so far is take my wbc's to 0.4. I'm
After FCR chemo 15 years ago and numerous oral medications since I am in chemo again. They tried a milder chemo to reduce my lymph nodes (they were huge). Some success, but not as much as I needed. So now I've had one round of R-CHOP. All that it has done for me so far is take my wbc's to 0.4. I'm
scorpio74944
in
CLL Support
5 months ago
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