Experiences with

Fludarabine

New Labeling for In November, the FDA updated drug labeling for fludarabine as part of its Project Renewal program, an initiative that aims to make sure the prescribing information for older oncology drugs remains clinically meaningful and up to date.

Those older chemoimmunotherapy treatments, typically Bendamustine + Rituximab (BR) or Fludarabine + Cyclophosphamide + Rituximab (FCR), selected for tougher to treat sub-clones, which they cause through inducing DNA damage that will hopefully trigger apoptosis [u]if[/u] the TP53 gene isn't mutated or

An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999, Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up, reports ~47% of patients with mutated IGHV

I’m seeking advice on next treatment option for CLL. I already did Gazyva/Venclexta , which got me 3.5 years. Have to make a decision soon about next treatment. My lymph nodes are big and uncomfortable and my neutrophil and platelet counts are dropping. I was diagnosed at 39 and am almost 53. I had

Long time no post! 17 years with CLL my general health remains excellent. Now 2.5 years on Vclax (mono and on it indefinitely), after a very shaky start (wiped out neutrophils and platelets which meant I got pneumonia and sepsis), the last two years I’ve had no side affects and health has been fantastic

There is now a new consensus statement for the treatment of CLL in Greece. The statement was published on 1 March 2025 and provides treatment recommendations for both first-line and relapsed refractory CLL. [i]"Abstract. Background: [/i][i]New targeted therapies have revolutionized the treatment

In February of this year (2025), the NCCN added AV (Acalabrutinib/Calquence plus Venetoclax) and AVO (AV plus Obinutuzumab/Gazva) for first line treatment to its Clinical Guidelines for CLL, page CSLL-D, despite the fact that these 2 treatment regimes are not yet approved by the FDA or any other regulatory

I have CLL since 2010. Had chemo in 2013 -2014 FCR treatmentfor 6 months which I had posted some years ago. Had relapsed in 2020 so was given Imbuvica which has been working well for almost 5 years now. I am on vacation till early April and when I return my hematologist is intending to maybe change

Just wondering……. I just completed two years of treatment in the V plus R arm of the LOXO trial in July 2024. Had a great response: MRD negative in blood and bone. This is my third line of treatment after FCR in 2012 followed by a trial of acala in 2017-22. The LOXO protocol provides that if I make

just wanted to share our news that today we have now celebrated 5 years post FCR . My husband was diagnosed in 2016 with CLL. We then had nearly 5 years of W&W until treatment beckoned in the most unfortunate year - 2020 covid., where we were allocated FCR via the UK flair trial. He’s IGVA unmutated

Hi everyone, It’s been months since I posted here. My husband had an allogenic stem cell transplant last August 22 to treat high risk “treatment related” MDS that he developed 9.5 years after completing 6 months of FCR chemotherapy for CLL. The transplant process was every bit as challenging and demanding

Has anyone had experience with dental implants either individual teeth or for dentures? ??? infection or failure v long term success? I've had CLL for 15 plus years had FCR in 2018 V + O for 18 months ending in August 2024 I'm now missing 8 teeth due to failed crowns root canals etc and All

I'm 71 years old and retired, just completing 4 years of watch and wait, asymptomatic except for slowly declining Hgb and unstable platelet count. My FISH test was negative for trisomy 12, D13S319, p53 and ATM. My hemoglobin suddenly dropped from 9.2 to 7.8 over a six week period, and my hematologist

Hi and Happy Holidays, New Year, Christmas, Hanukkah, Kawanzaa (Did I miss anything?). My wife, the well-meaning Vegan in my life and healthy advocate of getting rid of diabetes in the world (a wonderful lofty goal even if she gets only a few converts amongst our family and friends), read about a

After diagnosed with CLL, unmutated, Trisomie 12, cd38 neg, Zap 70 30%, I received FCR 6 cycles. Afterwards 9 years therapy free in 10/2022 got a DLBCL and was treated with R CHOP 14 6 times. Suspicion of Richters because of CLL. But clonal checks in special LAB showed no relationship with CLL and PET

Four years after FCR or chemo treatment, and three and a half years after Gyzava or immunotherapy now I am taking Brukinsa. Does anybody have a similar experience? How long can Brukinsa keep me going? Thank you

Hi everyone , I am so glad with this site. My name is Anja, 67 years old , and I live in the Netherlands. I was diagnosed with CLL in september 2010. In 2012 I got FCR for six rounds. After that I was stuffy and it occurred that I had heart failure because of the chemo therapy. It took me years

I was diagnosed with CLL in 2002 & been on wait & watch until recently. Treatment with FCR is imminent but only after a severe skin infection has cleared up. Dermatologist took 2 biopsies which the Pathologist reported skin infection/rash was Hypersensitive Dermatitis. I had an IV when I had a CT

Hi I had 3 rounds FCR in Winter 2018 stopped for Neutropenia. My doc did NO testing for mrd or even flow. Ignorance was bliss til release 2 years later. Started V + O March 2023 for R/R. At one year, 3/24 was umrd 4 on PB and 4/10,000 on BM. 5 months later or month 18 of Ven mrd increased

Hi. I live in Adelaide, Australia and I'm anxious about possible treatments now. I was diagnosed at the end of 2016. Starting in 2019 I've had FCR, Nov 2022 splenomegaly and other leukemia symptoms so January 2023 I started on Ibrutinib, giving partial remission but with colitis side effects. Sept