LOXO-305 TRIAL UPDATE TWO MONTHS IN
Hey everyone, I started this trial on 2/02/2020 at Memorial Sloan Kettering in NJ. After being diagnosed in 2009 with CLL, I have been through 3 prior treatments, FCR, Ibrutinib and Venclaxta. I had a 5 1/2 year remission with FCR, 3 with Ibrutinib,and about 18 months with Venclaxta. After my relapse in December 2019, I was offered a place in the LOXO trial. BMB, CT Scan and numerous blood tests were all completed prior to acceptance, I almost missed the trial because my platelets were too low, 29. I started the dosing with the max amount of 300 mg. There is quite a bit of testing for the first 30 days, then it slows down. I've had zero reactions to the drug, so far so good. My ANC has gone from .9 to 2.9 platelets 29 to 113 and all of the reds have improved greatly. Dr. Mato is very happy, and so am I. My CLL loves my bone marrow and always sets up lodging there, my routine blood testing tells all, I always get very anemic. Never had a swollen gland, node or organ. My 11q and a few other abnormal deletions and mutations has put me into a higher risk category. There will about 150 patients in this phase 1 study worldwide , MSK is going to have about 50 of the slots. From what I am being told, a good number of the participants are getting good responses. We all hope it continues.
FLAIR Trial 2018 update
FCR + Ibrutinib trial
Do FCR trials ever end early when the results are very favorable?
Clinical Trial
