Vecabrutinib clinical trial?

[Asclepiusone]

Does anyone have any experience on the vecabrutinib clinical trial from a company called sunesis? I believe it is being developed for those who are or have become resistant to ibrutinib for cll and other B cell cancers.

[cllady01 Former Volunteer]

Vecabutinib seems to be in process of trial, but it is very early for any info that can be reliable. The trials being done by the company will have to show its efficacy for it to be approved for bigger trials. At least that looks like that is where it was in June of this year.

"Preliminary data reported today were available from 23 patients treated in the trial thus far. These included 19 CLL patients, two mantle cell lymphoma (MCL) patients, and two Waldenstrom Macroglobulinemia (WM) patients. Patients had received an average of 4 lines of prior therapy, and all patients had progressed on prior BTKi therapy. 61% of CLL patients enrolled had a BTK C481 mutation as of the data cutoff for the poster."

globenewswire.com/news-rele...

[Asclepiusone in reply to cllady01]

Thx for the reply and update. I meant more first person experience on the drug if anyone has participated in that trial you speak of. Sounds very interesting.

[cllady01 Former Volunteer in reply to Asclepiusone]

There were so few who participated, it would be surprising, but interesting to have a firsthand review.

[cajunjeff]

I do not have any firsthand experience with the trial. The article is confusing to me. The article described the results as encouraging, but when you read further it seems only 4 of the 19 cll people enrolled in the trial had stable disease and there were a high number of serious adverse events, apparently not drug related.

I suppose that they are seeing signs that lead them to believe that the drug is working and more will become stable, I don't know, I do not know enough to understand what their expectations were.

One thing for sure, its a challenging group they are working with, so getting any response might be encouraging. And because vecabrutinib is a non covalent binding drug, I guess they would not expect it to work as fast as the covalent binding btk's like ibrutinib.

[cllady01 Former Volunteer in reply to cajunjeff]

It looks to be the preliminary tests by the company to get approval to do clinical trial.

It is way early to be able to say much about it. And I agree it doesn't look too promising as far as the statistics are concerned. But they are stating they will have a more thorough report within this year.

[Asclepiusone in reply to cllady01]

After reviewing, it looks like an early look at something ongoing and in a very very sick patient population that has failed most if not all other treatment options. Seems like the we’re discussing data that was not yet at a dose thought to be provide efficacy. I wonder what type of progress this trial has made toward higher doses and if the patients have had any success. A friend of mine is currently doing a chemo course, and though I’m no expert, seems unnecessary.

[cllady01 Former Volunteer in reply to Asclepiusone]

In what respect do you you think the treatment is unnecessary? Do you have the information on your friends CLL profile?

Treatment depends on symptoms being shown, age of the patient, and the profile of the CLL as well as the over-all health of the patient.

EDIT: And treatment also depends on the country in which a patient resides and is treated, because some countries take longer to get the newer medicines into their protocol.