Started Clinical trial-obinutuzumab+ venetoclax

[Elam]

Started 3 days ago. Included bendamustine due to lymph size. Day before treatment WBC at 173. After 2 treatments of bene. + obib. WBC at 17. Uric acid up over normal but kidney functions OK. Not much sleep 1st 2 nights but feeling better now. Thoughts and experience with those in this trial appreciated.

[LovecuresCLL]

On O plus V, only six weeks into combination and going extremely well.

[PlanetaryKim]

Good luck to you, Elam. Great to see that drop in WBC!

[AllanJardin]

Good luck to you.

[Smakwater]

Elam,

Is your trial O + V + B, or O + V?

Can you provide an NCT number for the trial?

JM

[Elam in reply to Smakwater]

The number is M16-788, Phase 3b. It is obin + bene for about 2 months for debulking, then obin with a ramp up to vene for 5 months, then just vene for 7 months.

[Smakwater]

It is very similar to the trial I am in, however, we are debulked with either bendamustine or obinutuizumab rather than both. I was given obinutuzumab.

I am 59 years old with no co-morbidities and considered fit. My prognostics are unmutated IGHV, CD20, CD38. I am at 8 months into the trial and currently at 4 month into 400 mg venetoclax alone.

The initial debulking produced some mild adversities, however, my CBC numbers returned to normal at about 6 weeks, and my fatigue disappeared.

I noticed only mild adverse conditions with the venetoclax ramp up, primarily diarrhea and nausea. I experienced a creatinine level risk caused from lack of hydration due to increased exercise with no increase in water intake.

Since the time I achieved full dose venetoclax until now, I would say that my overall health has improved greatly, however, I have intermittent aggravations with dry cough and productive sinuses.

I also have some joint pain and muscle cramps which I cannot accurately attribute to the drugs.

I developed neutropenia at 4 months on venetoclax, and I was given a G-CSF (Zarxio) which increased my ANC from .97 to 6.7. The G-CSF injection was administered 4 1/2 months ago, and my ANC is now down around 1.0.

I am scheduled for a bone marrow biopsy next week to determine progress.

I would offer that it is very important to drink between 60 and 80 ounces of water during a moderate activity 24 hour period, and increase the intake appropriately with increase in activity or environmental changes.

All the best to you with your treatment.

JM

[thompsonellen]

Did O + V + I trial. Started 3 years ago. Last official follow up is this Wednesday. All is well. First hour of obin infusion not fun, and hospitalized for first 2 V doses because I was very bulky, but otherwise uneventful. You'll do great.

[acanfill]

Elam,

I was scheduled for obinutuzumab & bendamustine in January, but 2nd opinion from md Anderson in November changed that. Still haven't been treated, Dr

Wierda said blood test in 6 mos. return next year for appt.

Hope you are doing well...

Drew

[Elam]

An update on my progress. First 2 treatments hit me pretty hard, but 3rd better. WBC down to 2.8 after 3rd. Uric acid elevated but now back to normal. Nutr# at 2.2, need to watch. Biggest issue has been digestion issues (constipation), but that is better. Sleeping night after treatments an issue I think due to steroids. All in all, not too bad and doctor pleased with numbers. Hoping I won't require the bendamustine in the 2nd cycle. As I read the trial description, I think that is possible.