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CLL Support Association
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Raising levels of LDH in CLL

Hi, long time since last post. My mother seems to be doing well on Ibrutinib. She is 17p deletion and trysome 12, her levels of WBC were from 130 when started treatment to 16 in 4 months, but we have a concern about her LDH that has been raising from 350 to 450 and now she is 530 during the last 3 months. She doesn't have any other syntoms of the disease, but we want to know if there is a risk of other forms or disease or agressivnes of CLL even she has no other syntoms. Has anyone knows or experience it during treatment or knows what can it cause it?

Thanks, best wishes for you all!

8 Replies

I do not have any experience with treatment or HDL. I googled "significance of LDH in blood tests. The following may be of help to you in understanding the overall perspective, but as usual, it is an individual situation with each of us--


Surely someone will come to be more specific to what may be expected in CLL with ibrutinib treatment.


Thanks for your response. Very helpful

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Nicolas, please note the correction in my reply. I did a transposing of letters and referenced HDL instead of LDH.

That has been corrected after I read lankisterguy's reply.


Hi cllady,

HDL and LDH are entirely different -

As the link you posted indicated HDL is the "good" cholesterol in the blood.

Here is the correct link for LDH,


SNIP: A lactate dehydrogenase (LD or LDH) test is a non-specific test that may be used in the evaluation of a number of diseases and conditions. LD is an enzyme that is found in almost all of the body's cells (as well as in bacteria) and is released from cells into the fluid portion of blood (serum or plasma) when cells are damaged or destroyed. Thus, the blood level of LD is a general indicator of tissue and cellular damage


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Len, A typo was made, thank you, for the info--and the correction.


I would request a PET scan or if not available a CTscan....ASAP...

LDH levels that high might indicate a transformation, but there could be other causes. As Dr. Thompson points out transformations usually include a lot of sickness, and B symptoms, like night sweats, weight loss fatigue etc.

A PET scan could indicate internal nodes or spleen with high metabolic turn over... and would help determine if a biopsy is required.

Dr. Thompson on LDH in CLL




Thank you Chris for your answer, I will ask for the Pet scan or the CTscan. Have a nice end of the week


Keep us posted!



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