CLL Support Association
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Biologic or Immune Therapies for CLL

Hi Friends,

This week’s update on the CLL Society website is my unscripted recordings on biologic or immunotherapies .

I start by reviewing my take on the good and bad of the well known and novel antibodies directed against our B cells by targeting its surface marker CD20. These include rituximab (Rituxan), ofatuzumab (Arzerra), and obinituzumab (Gazyva). Among other topics, I discuss the difference between type I and type II monoclonal antibodies.

I also cover other antibodies, new and old, IMIDS (immune modulating drugs) such as lenalidomide (Revlimid) vaccines, and more.

To listen please, visit the treatment section (found under the Basics tab) of the CLL website by clicking here:

Please let us know if this helps. I am particularly proud of this recording as it was done live and spontaneously with no notes. I think is ends up being more focused, ironically similar to the drugs discussed.

We plan on bringing more of this type of content. Your feedback on the website or to me by email informs what we add and how we will grow the website. Although there is only myself, my wife (both unpaid) and a wonderful RN, Betsy Dennison as the team, we listen carefully to all comments to help brings what’s needed to best manage our cancer. Smart patients get smart care.

As always, all our content is free and accessible to anyone but if you want we'd like it if signed up for the weekly alerts to know when we post new content, 1 to 3 x a week, and for our inaugural newsletters which will be amazing. We understand the importance of privacy and don’t share any personal info.

The artwork in the background of the video is again my son, Will Koffman’s tribute to Durer’s Four Horsemen of the Apocalypse. Will rendered the entire work using only bleach on black cotton.


Stay strong.

We are all in this together.


Volunteer Medical Director, CLL Society Inc.

4 Replies

Thanks very much for this informative and helpful video.

I’m sure everyone that reads your blog is very appreciative of your knowledge & the time you are spending helping us understand CLL.




Hi although you interview a whole host of experts you yourself must have some opinions which I would love to hear. Best wishes


Thanks. I will post on my blog more about my thoughts, but swamped with work most days. Brian from muggy Texas


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