Combination therapy for our CLL: Hi, This week... - CLL Support

CLL Support

16,300 members26,304 posts

Combination therapy for our CLL

bkoffmanCLL CURE Hero


This week, I am sharing a video of Dr. Jennifer Brown from Dana Farber Cancer Institute where she discusses the possible next steps in combination treatment strategies for chronic lymphocytic leukemia (CLL). You can read my summary and watch the interview here:

This is the future. This is where we need more research. This is the only path to time limited curative treatment with drugs. Cellular therapy may prove another path, but is till high risk

NEXT WEEK, we'll be publishing the first 2017 issue of The CLL Tribune and marking the 2 year anniversary since our website went live! Stay tuned!

Stay strong.

We are all in this together.


18 Replies

Thank you, Brian! Please read question at end of this post -thank you.

The "yet to be" ... hopeful and sobering I sit here with a new flair of hip arthralgia - ibrutinib has been reduced to 280 mg but the flairs persist -

which now include a new adverse effect - an interesting patch of fungus above the waist on both sides.

Now I too know the delightful experience of jock itch! ( tinea cruris) ...

( miconazole nitrate sprays have contained the little bugger) Lotrimin

Thanks for all you do for the CLL community. ... & One more question -

Since miconazole is a CYP3A4 inhibitor - would the grapefruit effect be possible with a topical application? Just wondering if miconazole increased the toxicity of ibrutinib?

- Diana

Thanks again!

bkoffmanCLL CURE Hero in reply to db601

Most topicals are absorbed but unless there is broken skin or a massive amount being used, you should be fine. Keep the area dry (pat in dry, don't rub it) and exposed to the air as much as possible without getting arrested. Stay strong, Brian

db601 in reply to bkoffman

As always ... welcomed advice. Thank you. &

I will refrain from airing my jock itch in public!


Thanks Brian. I would love to know if I'd spaced out my 6 rounds of FCR and put some of the inhibitor drugs in between, what the long term result would be. Which would come first though? ( Chickens and eggs please reply)

Many thanks,


bkoffmanCLL CURE Hero in reply to Ernest2

That would be creating an entirely new therapy protocol with no safety or efficacy data. Also you would be using a lot of drugs upfront with no assurance that this would be a curative approach. I probably wouldn't want to do that experiment on myself.

Thank you, Brain,

maybe you can answer another question, whether it would be possible for CLL patients like me to take part as spectator in the IWCLL 2017 in New York City.

best regards


Justasheet1 in reply to seoul

I wish somebody would call me Brain too.

seoul in reply to Justasheet1

I guess, Brian knows, he is not Brain but Brian!!!

Justasheet1 in reply to seoul

He's actually both. 😎

I wish that I had a brain! 😎


Justasheet1 in reply to seoul

Translation please?

CllcanadaTop Poster CURE Hero in reply to Justasheet1


Thanks Chris. 😎

seoul in reply to Cllcanada


seoul in reply to seoul

or Vielen Dank!😉

Justasheet1 in reply to seoul

You're welcome Seoul. Just playing around.


Humor seems always be a good therapy, doesn't it? 🤓🇩🇪🇰🇷🇬🇧🇺🇸

You may also like...