This week, I am sharing a video of Dr. Jennifer Brown from Dana Farber Cancer Institute where she discusses the possible next steps in combination treatment strategies for chronic lymphocytic leukemia (CLL). You can read my summary and watch the interview here: cllsociety.org/2017/03/comb...
This is the future. This is where we need more research. This is the only path to time limited curative treatment with drugs. Cellular therapy may prove another path, but is till high risk
NEXT WEEK, we'll be publishing the first 2017 issue of The CLL Tribune and marking the 2 year anniversary since our website went live! Stay tuned!
Thank you, Brian! Please read question at end of this post -thank you.
The "yet to be" ... hopeful and sobering ...as I sit here with a new flair of hip arthralgia - ibrutinib has been reduced to 280 mg but the flairs persist -
which now include a new adverse effect - an interesting patch of fungus above the waist on both sides.
Now I too know the delightful experience of jock itch! ( tinea cruris) ...
( miconazole nitrate sprays have contained the little bugger) Lotrimin
Thanks for all you do for the CLL community. ... & One more question -
Since miconazole is a CYP3A4 inhibitor - would the grapefruit effect be possible with a topical application? Just wondering if miconazole increased the toxicity of ibrutinib?
Most topicals are absorbed but unless there is broken skin or a massive amount being used, you should be fine. Keep the area dry (pat in dry, don't rub it) and exposed to the air as much as possible without getting arrested. Stay strong, Brian
Thanks Brian. I would love to know if I'd spaced out my 6 rounds of FCR and put some of the inhibitor drugs in between, what the long term result would be. Which would come first though? ( Chickens and eggs please reply)
That would be creating an entirely new therapy protocol with no safety or efficacy data. Also you would be using a lot of drugs upfront with no assurance that this would be a curative approach. I probably wouldn't want to do that experiment on myself.
maybe you can answer another question, whether it would be possible for CLL patients like me to take part as spectator in the IWCLL 2017 in New York City.
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Has anyone been on the combination therapy of Venetoclax, Ibrutinib and Obinutuzumab?
V & O combination therapy
Hypochondriac and CLL - not a good combination
COVID-19 among fit patients with CLL treated with venetoclax-based combinations
