I hope somebody out there can help. I have been taking 100 mgs of Sertraline for 2 weeks prior to that 50 mgs for the preceding 4 weeks. I suffer from quite severe GAD and since January 2013 became quite depressed which is the reason I took the Sertraline. I have a constant (every day no let up, not relieved by any of the over the counter meds nor in the past any prescribed by a neurologist) headache and also neck and shoulder problems which I have always accepted as being due to tension linked to the anxiety and depression. When i get better I still have a residual headache and neck issue but I can cope with it. I had MRI and CT scans in 2008 which ruled out more insidious causes of the headache in an earlier bout of illness. I have tried lots of different meds since 2001 (Citalopram, Ecitalopram, Seroxat, Fluoxetine and clomapramine) non seem to have helped with the anxiety but have had minor beneficial effects on any linked depression. I always give them a couple of months to bed in despite the horrible side effects (for me increased anxiety) and then I discontinue them. I seemed to get no benefit from 50mgs of Sertraline. Since I have been on 100mgs of Sertraline I noticed the initial increase in anxiety as expected when you change the dose, then i thought my mood was lightening a bit. However, over the last 3 days I have noticed a significant worsening in the headache and neck and shoulder tension this makes it incredibly difficult for me to concentrate at all as my focus is difficult to shift from the discomfort. I also feel very spaced out and really don't feel right and don't seem to have any every day thoughts and feel very flat emotionally and struggle even more to engage with people and go out. Has anybody else noticed this kind of effect on Sertraline? I am going to discuss with the doctor tomorrow reducing dose/coming off all together as i think 6 weeks is likely to be long enough to establish whether it is going to work for me, any views on this? Whilst i know medication is not really the answer sometimes we need a little help to get us in a position were we can live a life again. I know medication is an individual thing but has anybody found anything excluding the above for GAD that works for them. Because my condition is long term I accept diazapam etc is not useful. Or, is it likely that some of us will just have to accept medications will not work for us for whatever reason?