Fresh remyelination news

[monkeybus]

We are cured (again).

A clinical trial of the cancer drug bexarotene showed that it repaired the protective myelin sheaths in Multiple Sclerosis patients.

The drug had some serious side-effects, from thyroid disease to raised levels of fats in the blood, which can lead to dangerous inflammation of the pancreas. But brain scans revealed that neurons had regrown their myelin sheaths.

So, that's that one ruled out.

There is a new trial up this year, This trial will monitor the effects of the diabetes drug metformin along with clemastine, an OTC antihistamine. They've both been shown to (safely???) promote remyelination, makes sense to try both together if so.

healthunlocked.com/amneasie...

healthunlocked.com/amneasie....

healthunlocked.com/amneasie...

Have a read about the trial, folks:

theguardian.com/society/202...

mssociety.org.uk/research/e....

ms-uk.org/potential-myelin-...

ajmc.com/view/researchers-h...

[nan17]

Thanks for your comprehensive review of these drugs to date. This information really helps.

[Hillary]

Wish we had a 😂😂 on here. Keep looking for a cure 😊

[SongStream]

Interesting. Min-102 is a derivative of several metabolites of pioglitazone, an anti diabetic drug. Here's a look: minoryx.com/leriglitazone/

Also of note, is the approval of a study in the EU involving male pediatric patients with first evidence of cerebral lesions: minoryx.com/leriglitazone/