Someone posted this information on Anyone familiar or gone through this treatment?

Recent research "Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase."

Pharmacological activation of AMPK can rescue the mitochondrial dysfunction and inhibit the pro-inflammatory response. The FDA approved anti-diabetic drug Metformin, a well-known AMPK activator, induces mitochondrial biogenesis and is documented for its anti-inflammatory role.

Taken together, these results provide proof-of-principle for therapeutic potential of metformin as a useful strategy for correcting the metabolic and inflammatory derangements in X-ALD by targeting AMPK. We document the therapeutic potential of FDA approved drug, Metformin, for X-ALD by targeting AMPK. Metformin induced peroxisomal Abcd2 levels in vitro and in vivo. Metformin lowered VLCFA levels, improved mitochondrial function and ameliorated inflammatory gene expression in X-ALD patient-derived cells.

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SongStream, thanks a lot.

I'll look into this. We all should start investigating ways to upregulate ACBD2.

I started making a list of candidate drugs. I'll post it up in the week, but Metformin looks very promising.


Here is the full article, have to pay $6 to read it though.

I'll sort this later in the week.

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Thanks Monkeybus. A common adverse effect of this drug is gastrointestinal issues such as diarrhea, vomiting, etc. I'd be concerned how it affects those with Addison's. Nevertheless, it sounds promising.


I'm going to add it to my list to talk to the neurologist. I'm taking all these screenshots and need to go through them and right all this down


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