4-AP improves motor function in patients with AMN

[monkeybus]

Has this already been posted?

I'm doing this on my phone, and I've just lost the link. I'll edit this on my PC later.

Still, an actual clinical trial for 4-AP in AMN patients.

I've just received my monthly delivery of 4-Aminopyridine-3-methanol. Excellent. I'd love to see some clinical trials of 4-ap-3-meoh in the future.

Improvement of motor function in patients with AMN

Pr. Wolfgang Köhler (Germany)

Leg stiffness and walking disabilities are leading symptoms in patients with Adrenomyeloneuropathy

(AMN). The reasons for this spasticity are spinal cord long nerve fiber and myelin damage. The nerve fibers of the spinal cord carry the electrical impulses that transport information from and to the brain to support the complex control system of the human body. Each microscopically thin nerve fiber is insulated by a regular pattern of myelin sheaths along its length that allow for the efficient conduction of electrical impulses. In AMN some of these myelin sheaths can be damaged leading to an impairment or even disruption of neural conduction of movement information from brain to the muscle. Nerve impulses "short circuit" in demyelinated axons, much like electricity in a wire whose insulation is stripped. Thus, even though a demyelinated axon is alive, it is unable transmit motor or sensory impulses.

Treatment with 4‐Aminopyridine (4‐AP) permits the axon to transmit impulses again, improve nerve conduction thus leading to reduced spasticity and improved walking abilities in patients with multiple sclerosis. Since in AMN similar clinical symptoms are present, we treated 18 AMN patients with 4‐AP using a standardized study protocol. 13 out of 18 patients improved significantly regarding a timed 25 foot walking distance. 15 out of 18 patients reported significant reduction of spasticity and pain, 9 out of 18 improved with their bladder function. In summary treatment with 4‐AP may significantly improve walking disabilities caused by spastic paraparesis in most patients with AMN.

mod4alll.com/store/index.ph...

Edit: Finally edited it after two years.

[tieaknot]

hey there! I know this is an old post but are you still on the 4-AP-3 meoh? Where do you get it?

My Neuro tried to write for the generic Ampyra for me but insurance is refusing as usual. We are thinking of trying the compounded 4-ap but I did some reading and the one you are on in interesting to me.

[monkeybus in reply to tieaknot]

Just seen your reply. I couldn't imagine life without 4-AP. That stuff rescued me when the spasticity started to take hold.

Before Covid, when I used to go out to work every day, I couldn't afford to take the 4-AP-3-MeOH every day, made do with regular 4-AP. Now that I work at home, the meoh is pretty much all I take whenever I go out.

I edited my original post with the proper link to where I get it. Though you'd better send them an email first. They always sell out.

It's criminal how much Ampyra costs. Considering how well it works (for those it helps) and how cheap 4-AP actually is.

I have recently been experimenting, taking it with Tizanidine as well. Makes a difference, certainly easier to walk, but that Tizanidine really makes me tired.

[Golfdog3 in reply to monkeybus]

this is very interesting. are there any side effects with either of them? Seems like it might be an option on those bad days or if you need to get around a little better. How long does it help? Thank you!

[monkeybus in reply to Golfdog3]

The 4-AP can make you feel like pins and needles all over your body if you take too much in one go. the 4-AP-3-MeOH is a much lower dose, and it's more effective. Doesn't give me any side-effects.

The capsules kick in after 10 mins and it lasts for an hour or so. When I used to have to be on my feet all day I'd take 5mg every hour. Plenty of people with MS take it, that's where I first found out about it.

[Coslet]

I caution anyone ordering from the above site. I made an order with these people 2+ years ago. Never received order. Emailed. No reply. Fast forward to two days ago when this thread popped back up. I make an order again forgetting what happened last time. I thought it strange I had an account already but assumed I had looked before but not purchased. Then I saw a tab for past orders. There was my first order, “pending”. I’ve now lost nearly $200 with this site.

Proof of orders.

[monkeybus in reply to Coslet]

Did you actually check your credit card statements, though?

Has any money at all been actually charged? I'd be extremely surprised if it has. In fact I'll bet money against it.

[Coslet in reply to monkeybus]

I’m going back and checking. Why is your first assumption that they took my order but never processed it or charged for it?

[monkeybus in reply to Coslet]

It always says "pending", is all. Doesn't mean charged.

Check your statements. Mod4all is hardly Amazon in it's efficiency. It is run by a man sicker than any of us. But fraud is something else.

[Coslet]

I’ve emailed and I get no reply. I’m checking today to see if my identity was stolen around the time of the first order. I do remember that happening a few years back.

[Golfdog3]

Has anyone ordered from Mod4All in awhile? I ordered about a month ago and my order still says pending. I checked my credit card and they hadn't charged it either. I've emailed weekly and I don't ever get a response. I was looking forward to trying it. Any other options that people have used?

[Coslet in reply to Golfdog3]

see my comments above. I presently believe they are doing nothing but defrauding people who need help.

[tieaknot]

Hello! I recently was able to get dalfampridine (generic for Ampyra) which is the extended release 4-AP prescription version previously only covered for MS in the USA. Now that there is a generic, my insurance covered it for AMN through a specialty pharmacy here. You take it only 1-2 times a day. I’ve tried it for a couple weeks and it does seem to help my walking…however I noticed a big increase in my back and leg pain on the days I took it. I was only taking one dose in the morning.

Hoping it was coincidence…will try again after a little break and see if the pain quiets down. What a trade off…I hope it isn’t a side effect for me. 😕

[3WheelWonder in reply to tieaknot]

these help …a lot.