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4-AP improves motor function in patients with AMN

Has this already been posted?

I'm doing this on my phone, and I've just lost the link. I'll edit this on my PC later.

Still, an actual clinical trial for 4-AP in AMN patients.

I've just received my monthly delivery of 4-Aminopyridine-3-methanol. Excellent. I'd love to see some clinical trials of 4-ap-3-meoh in the future.

Improvement of motor function in patients with AMN

Pr. Wolfgang Köhler (Germany)

Leg stiffness and walking disabilities are leading symptoms in patients with Adrenomyeloneuropathy

(AMN). The reasons for this spasticity are spinal cord long nerve fiber and myelin damage. The nerve

fibers of the spinal cord carry the electrical impulses that transport information from and to the brain

to support the complex control system of the human body. Each microscopically thin nerve fiber is

insulated by a regular pattern of myelin sheaths along its length that allow for the efficient

conduction of electrical impulses. In AMN some of these myelin sheaths can be damaged leading to

an impairment or even disruption of neural conduction of movement information from brain to the

muscle. Nerve impulses "short circuit" in demyelinated axons, much like electricity in a wire whose

insulation is stripped. Thus, even though a demyelinated axon is alive, it is unable transmit motor or

sensory impulses.

Treatment with 4‐Aminopyridine (4‐AP) permits the axon to transmit impulses again, improve nerve

conduction thus leading to reduced spasticity and improved walking abilities in patients with multiple

sclerosis. Since in AMN similar clinical symptoms are present, we treated 18 AMN patients with 4‐AP

using a standardized study protocol. 13 out of 18 patients improved significantly regarding a timed‐

25 foot walking distance. 15 out of 18 patients reported significant reduction of spasticity and pain, 9

out of 18 improved with their bladder function. In summary treatment with 4‐AP may significantly

improve walking disabilities caused by spastic paraparesis in most patients with AMN.

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