Here we go with Lynparza

[Pmann]

Morning folks,

Well I start my Lynparza treatment today. Seems crazy that I would be happy to have the gene mutation that qualifies me for this therapy. I had no other bullets in my gun.

I heard from one other warrior about their results.

Does anyone else have experience with Lynparza they would like to share.

Fight on, never give up. Hope abounds.

[mrscruffy]

currently 13 months on Lynparza. So far smooth sailing with minimal SE's

[Pmann in reply to mrscruffy]

Thanks Scruffy,

How has it done from an efficacy standpoint, keeping that progression at bay?

[mrscruffy in reply to Pmann]

Real well no new Mets and existing staying suppressed

[Ian99]

Hi. I have often exchanged info with Scruffy. I have BRCA2 mutation. Began Lynparza June 1, 2024; my other option was Docetaxel. I began on 600mg/day for 3 months, was in bed at the end. Lowered dosage to 200 for 4 weeks, then 300 for 2 weeks and finally 400 from October. Am tolerating it. Red and white blood cell counts down a bit but not seriously. PSA dropped for the first time in years 61->49. Scans show no progression. I will have further results this week, blood counts for sure and scans later.

Given I am tolerating 400mg/day, I will continue with this as long as it’s effective. No other local cases here to compare with. See my profile for details.

[Pmann in reply to Ian99]

Thanks for the feedback Ian99

[Ian99 in reply to Pmann]

If I may ask, what dosage are you starting on?

[Pmann in reply to Ian99]

600 per day but she said that gave us room to lower if needed

[Ian99 in reply to Pmann]

I should say the decrease in PSA was due to the 600mg dosage. Since then only a slight drop. But blood counts are stable and so far no radiographic progression under the reduced dosage. Good luck.

To complete this: blood counts Jan 7 were stable. PSA has now dropped to 33. So the 400mg dosage is proving to be both tolerable and effective, for me so far.

[j-o-h-n]

Lynparza (Olaparib) - from cousin Googla

Lynparza is a prescription medication used to treat certain types of cancer. It is a poly (ADP-ribose) polymerase (PARP) inhibitor, which means it works by blocking an enzyme involved in DNA repair.

What foods should you avoid while taking LYNPARZA?

The blood levels of this medication can be affected by certain foods and medications, so they should be avoided. These include: grapefruit, grapefruit juice, Seville oranges, ketoconazole, rifampin, phenytoin, St. John's wort, and modafinil, among others.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Poweredparaglider]

I have acquired BRCA1, BRCA1, and ATM. Started Lynparza at 200/day for a month, then 400, then 600. LOTS of fatigue, no other SE. PSA went from 7 to 33. Alk Phos went from 275 to 400. I also now have visceral disease, a tumor on my liver at 12cm x 9cm.

Lynparza was a bust. Hope it works for others.

[Cooolone]

One year+ now, added to Darolutamide and Degarelix. Steady as she goes! Borderline anemia and definite energy and stamina issues. Can do things, just not sustained for long durations as before. But it seems as the body has adjusted and can do more today, feel much better! I work out (Martial Arts) and went back a little over a year ago, but when started had to stop maybe 2mins after getting on the floor, now can workout the entire 1,5-2hr session, lol. Still have days where the battery is empty, but that's about it in regard to SE's. Overall, the desired effect is working (PCa). And that's all that matters right? I hope it works for a very, very long time!

Good Luck and Best Regards

[Pmann in reply to Cooolone]

Thanks for feedback

[mrssnappy]

Good luck Pmann! I hope it works for you. My husband's PSA went down a bit again on Dec. test, so Lynparza continues to work for him.

[Pmann in reply to mrssnappy]

Thank you for sharing

[davebliz]

I was on Olapirab for 7 months when it stopped working. It kept the tumours steady for those months with minimal side effects. Now I’m on Cabazaxel, doing 10 sessions. Good luck.

[Jazzman2023]

I'm 1 year into my diagnosis/treatment (BRCA2 positive), Gleason 9. Treatment in 2024 was 44 courses radiation to prostate bed and lymph nodes (based on PSMA PET scan). Currently on Orgovyx and Erleada... PSA remains at <0.02, and has been that way for about 6 months...Despite my BRCA2 mutation, PARP inhibitors were not prescribed for me. Perhaps down the road they will ??

[Pmann in reply to Jazzman2023]

They are probably saving it for when the second line drugs fail. Been on hormone therapy for years and danced with Erleada in 2020-2021

[speranza10 in reply to Jazzman2023]

You are brca positive, so in the future if things get dark they will use them. They did a study (propel study) and then approved the abiraterone + olaparib doublet in some countries but honestly I do not know exactly which patients this combination is recommended to and which could benefit from this combination.

[Har036]

My husband has ATM mutation and hasbeen on Lynparza since Sept 2020 but it was discontinued last week due low neutrophils. He also had a DVT and pulmonary embolism in December. He had been undetectable and his latest PSA increased to 0.104. Last year he had to take six weeks off and his counts went back up and was restarted. His side effects were mainly fatigue due to the decreased blood counts. His scans back in October showed no new lesions and the old ones were stable. Lynparza is not for everyone but it has worked for him. Prior to Lynparza he had been on Abiraterone/Prednisone and it failed after only four months. He has remained on Eligard and completed six Xofigo treatments in 2021.

I pray that you’ll get good mileage out of this treatment with minimal side effects.