Has anyone been successful in knocking out a Klebsiella pneumoniae UTI?

[CancerConcierge]

My husband has struggled with recurrent UTIs since 2020 when he was diagnosed with bladder cancer , had several bladder surgeries, many cystoscopies, and yearly prostate biopsies….so a lot of poking around ..

He has been on antibiotics many times , and has been on daily low dose bactrim for almost a year for a Klebsiella pneumoniae infection that always reoccurs when he tries to go off . He had one consult with an infectious disease doctor at Mayo , otherwise sees a Urology PA at Mayo .

He tried another antibiotic for about a month in June , but the infection came back and he is back on Bactrim.

He is on Orgovyx, Abiraterone and Prednisone, post radiation, for Gleason 9 (PSA 46.6 before treatment)… but I think he worries more about the infection some days, than the cancer.

Any recommendations/ advice?

Thanks

[j-o-h-n]

Klebsiella pneumoniae is a contagious bacteria that can cause urinary tract infections (UTIs) in people who have catheters inserted during a hospital stay. UTIs caused by Klebsiella pneumoniae can be life-threatening, especially for people with serious illnesses.

findexpertmd.com/d/Klebsiel...

ABOVE IS A LIST YOU MAY WISH TO PERUSE.

Good Luck, Good Health and Good Humor.

j-o-h-n

[CancerConcierge in reply to j-o-h-n]

Thanks for the link.. We are in Arizona, and when I set the filter for AZ there were no names given.

I will look at nearby by states….maybe a Zoom consult.

It is frightening, for both of us, from everything we’ve read… the infectious disease Doctor only recommended a six month course of Bactrim … which did not resolve the infection. We will see if we can get scheduled with him again… our urologist did not refer at our request, but the MO did.

Thanks for your response!

[Doctorsceptic]

several thoughts. He almost certainly has scarring which provides a breeding ground for bacteria.

Has the Kleb culture been checked for antibiotic sensitivity/ resistance?

Have rotating antibiotics been considered?

A simple safe option which might be worth a shot is to take daily mannose. It is excreted in the urine and, since many bacteria use a mannose binding site to adhere to the bladder wall, the mannose helps elimination of the bacteria. May do nothing, but worth a shot for a few weeks. You can buy mannose on Amazon.

[CancerConcierge in reply to Doctorsceptic]

Thanks for responding… yes, the kleb culture was tested for antibiotic sensitivity.

He was recently switched to a new antibiotic, but the klebsiella came back … so he was put back on the Bactrim.

His new uro PA did just recommend PAC 36 mg ( cranberry extract) and D-Mannose … he started that a few days ago

It would be exciting if it helped!

[Doctorsceptic in reply to CancerConcierge]

Good luck. I would definitely raise the question of using a regime of rotating antibiotics. I doubt he can clear it completely but the goal will be to keep it suppressed.

[CancerConcierge in reply to Doctorsceptic]

Thanks… We can discuss that with the PA

[Oatmeal2]

I agree that Mannose D is very useful for UTIs. It comes in a powder or capsules and is widely available in most vitamin stores and online. He would need to take about 1500-2000 mg initially for a few days and then a maintenance dose of 1000 mg. He would also need to drink a full glass of water when taking the mannose. Drinking water also helps to flush out bacteria from the bladder.

[CancerConcierge in reply to Oatmeal2]

Thanks for responding.. He did start D-Mannose this past week … 1000 mg daily with PAC 36 mg… I’ll remind him about the extra water!

[Oatmeal2]

correction “D-Mannose”

[Explorer08]

my urologist recommended D-Mannose taken daily.

[CancerConcierge in reply to Explorer08]

Thanks … a lot of support for D-Mannose!

Really hope it will help!