My PSA went up after 3 weeks, as well. It is normal, according to my doctors. I was 99 at start and 106 after 3 weeks. Two weeks later (before my next treatment) it was 91.8.
My routine was to get blood drawn after 3 weeks and before next injection. So hang in there for a couple more weeks and see what happens.
After completing Pluvicto my PSA is now 6.5.
Also, I was told they do not expect a positive reaction until after the third injection so they were very pleased that I started down after the first one.
Your dear Dad had a RPD sometime before 2000, I had mine 2002. I'm 87 and what is your Dad's age? We both had the Old fashioned open RPD and I would say he's got lots and lots of years to go. Keep the faith and give him our regards.
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