My brother-in-law finished the full set of Pluvicto treatments about four weeks ago. He’d done pretty well on the Pluvicto treatments. Two weeks later he and his wife started a short vacation but got a call from his oncologist to return home immediately. He was diagnosed with extensive cancer throughout his kidneys and liver….not related to prostate cancer spread. He passed away just yesterday after starting hospice just last Saturday. His wife is convinced that it was the Pluvicto that caused the fast moving kidney/liver cancer. (He was an engineer by trade and curious about technology - - he’d purchased a Geiger counter when he started Pluvicto and it did register radiation emanating from his body.)
I am curious to know if anyone has heard of Pluvicto causing secondary cancers. I’ve been told that if and when my ADT meds fail, Pluvicto would be an option.
Thanks for any insights.
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Explorer08
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Pluvicto will not cause secondary cancers and especially not within weeks. Your brother-in-law had this cancer before the Pluvicto treatment. It had not been detected.
There are several studies out there that shows extremly good result on patients with low volume prostate cancer confined to lymph nodes when doing some cycles of Lutetium 177 (Pluvicto). You seem to be a very good candidate with only LN showing up on PET Scan.
Did do 3 cycles of Lutetium 177 myself when I did my treatment in Finland and my experience is; this was by far the most uneventful treatment I’ve done on my treatment Journey.
I'd ask your question over at this Pluvicto group. There are a lot of stories similar to yours where Pluvicto made things a lot worse. facebook.com/groups/6681290...
Following... my father is seeing less than stellar results from jevtana (current treatment) so doctor recommended we may be starting Pluvicto but I have been reading about mixed results on Pluvicto on here and other channels (i.e. FB group) so would love to hear about more experiences before we make a decision...
Had 3 cycles of Lutetium 177 as part of my treatment. In general I tolerated them well; became a little bit more tired and fatigue, in one of the cycles I became more dry in my mouth. But in all, this treatment was easier then I expected
my husband had 4 rounds. ALP & PSA numbers reached over 230 so a scan was done. He had major progression of bone Mets to the skeleton: skull to femurs. They did a biopsy to see if it was now small cell carcinoma. Results showed still PC. I read that 30% of men show improvement but I do know some men decline rapidly soon after treatments
Sorry to hear that Lutetium 177 (Pluvicto) didn’t work and it’s the sad truth of treatment, for some it works and for some it doesn’t and all this types of radiation treatments can be brutal of course.
Yes, from what I’ve seen the studies showed approx 30 % response in the group of heavy pre- treated patients that was having Pluvicto in these studies
Anyway, very sorry to hear that your husband was one of those who didn’t respond well to Pluvicto.
For one his life style and age and would be curious of if he had or was suffering from long Covid, with or without multiple vaccinations. Closet alcoholic and so on.
You would think prior body scans would have shown an indication of liver and kidney disease. I can think of many more investigative questions.
So sorry to hear about your brother-in-law. I completed the 4th infusion of Pluvicto in April and my PSA has been undetectable since then. I’ve been off the treatment since April, but yesterday my monthly PSA test showed an increase to 0.3, so I have a feeling my MO will want me to continue with round 5. I guess I’m one of the lucky good responders to Pluvicto. Most of my cancer is in the lymph nodes and prostate. So far I’ve had no adverse effects or other cancers showing up.
UNDERSTAND SOMETHING. We are all very sick guys with a disease that is killing us!!
DO NOT EXPECT MIRACLES OR BLAME ANYONE.
Some of us got very lucky, I am in year 26, but many do not live beyond a few years, so live large, make up a bucket list and do as much as can for as long as you can !!
Please do NOT ATTACK OR GO AFTER THISE WHO LOOK AFTER US! THEY ALL DO THEIR BEST FOR US!!!
Hi Billy - I agree with your sentiments but I don’t see where anyone here was attacking anyone else. Perhaps you can clarify where you see an attack in my original post or anyone’s. If you found something attacking in my original post, I greatly apoligize.
I am just very sensitive to people blaming or Looking for the impossible at the end of a person’s life. Advanced prostate cancer is a horror show of a disease and no matter what any of us do, it will get us- or maybe some other ailment not connected gets us. It is a Wild West of diseases as us Guinea pigs go our best as do our medical guys!
I have been very lucky for a long time, but my recent drug failure and very poor medical response cost me a year of life but that is the game being played! That is why this site is so important to and for us!!!
May your brother-in-law rest in peace, and may you pick up your gauntlet and in his honor continue your fight against those tiny little M.F. bastards (and I don't mean Mighty Fine).
It creates risks for those who are near the patient and that's a true fact. The problem I have with it is the fact that it only extends the life of the patient 3 months on average.
Once ADT stops working your comment about pluvitico extending 3 months applies to most drugs. I take cancer treatments for pain because I am incurable so when adt fails and the pain returns I’ll consider chemo. I’m not battling Psa. My Psa and scans will not dictate treatments. When QOL suffers I’ll consider other drugs.
Pluvicto may not be a magic bullet for all of us but it was a game changer for me. The scattered mets in my lungs are now “resolved” with one rogue tumor exception. But because only one was still growing I was able to have targeted radiation to it. Waiting for a future scan to determine if it, too, was taken care of.
Good luck and blessings be with us all (and our significant others). .
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