My husband was on Lupron (4 yrs) and it stopped working. His doctor added Xtandi. The first month it dropped his PSA 150 points then it slowly increased. He has been on it 4 months or so. Doctor wants him to get PLUVICTO™ (lutetium Lu 177 vipivotide tetraxetan) treatment. Has anyone had this treatment or have info about it. It has the following warnings, that seem almost impossible to do.
To minimize radiation exposure to others following administration of PLUVICTO, limit close contact (less than 3 feet) with household contacts for 2 days or with children and pregnant women for 7 days, refrain from sexual activity for 7 days, and sleep in a separate bedroom from household contacts for 3 days, from children for 7 days, or from pregnant women for 15 days.
Thank you in advance
Pluvicto plus Xtandi 
Any advice and tips about Pluvicto treatment... please!!
Docetaxil first, then Pluvicto or Pluvicto first
I am currently receiving a slightly different version of Pluvicto in a clinical trial, and I have been told that the initial precautions for Pluvicto were over blown (written by lawyers no doubt). I am told that after 24 hrs the radiation level is low enough to not be a threat. The main concern is to be very careful when urinating for the first couple of days, as urine caries most of the radiation out of the body. I was also told no "spooning" with the wife for a couple days after treatment
Thank you so much for you response. I was thinking the that the precautions were a CYA. As far as spooning, that is not a problem and we have a california king bed with lot's of room. Also it says not to let your pets get close to you, I guess that should be ok in 24 hour period.
I forgot to ask you about any side effects you are having, if any. I know everyone is different but just curious. I hope treatment working great for you.
So far I have only had 1 of 4 planned doses, but the side effects havent bad at all. I had very dry mouth for the first couple of nights, and there was more fatigue than what comes with Hormone treatment.I found a nice hour or 2 nap every day for the first week or so after treatment seemed to help with the fatigue. I have had increased pain in the area of some of my mets, but I hope that is the cancer dying from being attacked by the radiation. They tell me if you are going to have nausea, it usually comes on after the 2nd or third dose. I get another set of scans right before my next dose in 4 weeks, so I hope we can tell if its working or not at that time.
Once again thanks for your great info. I was concerned about the nausea. We will have to go to Houston, a 200 mile round trip and my Husband does not like my driving..lol.
we were concerned about that as well because we are driving 4.5 hrs from Oklahoma to Dallas for treatment. Like I said, no problems with nausea at all after first dose..... we will see what the 2nd, 3rd and 4th bring....
I am currently doing chemo for MCRPC and could very well be doing LU177 soon if the chemo is not effective or tolerated. If I do get LU177 I will be monitoring my radiation level carefully. I have a a very good radiation detector that I used for all radioactive treatments and could easily track the decline in radiation.
It would be awful to have to spend any more time than necessary not sleeping with my dogs.
When I had brachytherapy I was traveling with my emotional support dog who was very young and had not flown before so I thought she might need to sit on my radioactive lap. I bought a few square feet of sheet lead to put on my lap but never needed it. I guess I could get some more and wrap my dogs in lead. Not very cuddly though
it would be very informative to have real world data like that . They never actually tell you how radioactive you will be, just that you should be cautious for a couple of days
Remember. No spooning the dogs. I'm not sure about forking.
i have my lead sheet to put in-between. the ultimate cuddle condom.
The half-life of Lu177 is 6 days, just so you know. I had my first infusion almost a month ago. he only real side effect was Radiation Flare where an area of current pain/discomfort (in my case, my right 6th dorsal rib) was a bitch all night long and I did not sleep well. Next time will include ibuprofen that afternoon and again before bed.That strange discomfort is a common but not absolute side effect.My next one is Dec 30th as I talked them into a 7-week cycle. I did not want to have it on Dec 23rd and totally destroy the family Christmas time together.
My Xtandi experience was not fun. My love of food changed as the idea of a number of dishes and flavors turned south on me. I could also detect a level of depression setting in. I am so glad I was able to stop. I had been on Zytiga (Abiraterone) for over a year before that with absolutely no side effects at all.
Good luck to everyone on this forum!