Aggressive BRCA Gene Prostate Cancer

[Jecca201]

My Dad was diagnosed with metastasized prostate cancer 2020; spread to the bones so far no organs. He’s a VA patient and they are taking good care of him. He started hormone therapy right away. Now, 18 months later, his PSA is on the rise again. He starts chemo next week but they are testing him for BRCA and will change treatment to PARP if he is BRCA positive. I’ve Googled it but I’m finding very little information. I know everyone is different but I’d like to have some ideas of how folks are reacting to their PARP treatment in the event that this becomes his path. Has anyone here had this treatment or is caring for someone with it?

[Hidden]

If he's going to do chemotherapy and is positive for BRCA, they could possibly add Carboplatin to his chemotherapy. Platinum chemotherapy drugs are effective for PCa with BRCA mutations.

Just another option to discuss with his doctor.

[Jecca201 in reply to Hidden]

Thank you! I will definitely bring this up with my dad and his doctor. Couldn’t hurt to discuss it. Thank you.

[mrscruffy]

I am positive for BRCA2. As of this time I am still on Lupron/Zytiga. It has been 6 years next week and things are going well I know soon I will be headed down a different path but for now I am good. I am watching closely PARP inhibitors and LU-177 should things go sideways. Kind of a hurry up and wait situation

[Jecca201 in reply to mrscruffy]

Good luck to you sir. Thank you for your response.

[hopeful1956 in reply to mrscruffy]

My husband is positive BRCA2 as well. Was diagnosed almost 1 year ago. Currently on Zytiga, Prednisone and either a Placebo or Niraparib (in the Amplitude Study) and gets a Zoladex shot every 3 mths. So far so good, but it's still early.

[lespaul123]

What does PARP stand for? Thank you.

[TJGuy in reply to lespaul123]

PARP (poly-ADP ribose polymerase) is a enzyme (a protein) in our cells that help cells repair themselves.

This is bad for cancer cells that you want to kill, if they are able to repair the damage that treatment such as drugs, chemo, or radiation has done to them.

PARP inhibitors drugs given along with treatments act to prevent the cancer cells from repairing themselves hopefully leading to their death.

[lespaul123 in reply to TJGuy]

Thank You !!

[Jecca201 in reply to TJGuy]

Thank you

[HopingForTheBest1]

I am BRCA2+. I have been on several treatment regimens over the past 4 years, including Olaparib/Lynparza PARP. This drug was the most effective in keeping my PSA undetectable for 18 months before it ran its course. Currently on Cabazetaxl/Carboplatin chemo combo, including Neulasta to raise white blood cell count. 5 treatments so far with all nodules in the lungs resolved/gone except one that shrunk from 1.3cm to 3mm. Next treatment in 2 days.

[Jecca201 in reply to HopingForTheBest1]

Thank you!

[j-o-h-n]

Give your dear Dad my regards..........(you can hug and kiss him too)....

God Bless the past and active military service personnel.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 05/30/2022 8:04 PM DST

[Mgtd]

you may have better luck using google scholar.