Hi all. Any advice would be great. My dad is 65. Diagnosed very suddenly last august with very aggressive stage four prostate cancer. In the bones and lymphnodes. His psa was just under 1000. Gleason is 9. He did chemo doxtaxcel and injection of firmagon. His psa eventually went down to 60. But began rising slowly again a few months after chemo was over. Switched him to Lupron and Zytiga. Four weeks in and his psa has doubled in that time. Two weeks ago it was at 184. They will take his psa this week to see if the zytiga has kicked in but the dr didn't seem hopeful given the doubling during the first four weeks. If it rises again we are looking at 1) a different chemo 2) liquid radiation or 3) clinical trial. We are at memorial Sloan Kettering. Dr seemed most hopeful re clinical trial route given my dads age and aggressive cancer. Seems like the other option have low success given the aggressiveness of it. Does anyone have any thoughts? He's tired, in pain and has lost 32 pounds since march despite eating. He wants to fight though. Will a clinical trial just take him out completely? Anyone in a trial with similar issues at Sloan? Liquid radiation? Another chemo? Any thoughts appreciated I don't want him to give up but I want him to enjoy his life if life is short. Prognosis doesn't seem great given everything I've read,..